Results 61 to 70 of about 551,461 (318)

Feasibility of a prospective multicenter observational study—is diabetes a risk factor in ERAS joint arthroplasty?

Pilot and Feasibility Studies
Background Diabetes mellitus is a surgical risk factor, yet perioperative diabetes management remains debated, with inconsistent guidelines and limited consideration on the implementation of “enhanced recovery after surgery” (ERAS) programs.
Luma Mahmoud Issa, Christoffer Calov Jørgensen, Sten Madsbad, Martin Lindberg-Larsen, Claus Varnum, Thomas Jakobsen, Mikkel Rathsach Andersen, Manuel Josef Bieder, Søren Overgaard, Torben Bæk Hansen, Kirill Gromov, Henrik Kehlet   +11 more
doaj   +1 more source

A prospective randomised control trial comparing functional with mechanical axis alignment in total knee arthroplasty: study protocol for an investigator initiated trial

Trials, 2021
Background A drive to improve functional outcomes for patients undergoing total knee arthroplasty (TKA) has led to alternative alignment being used. Functional alignment (FA) uses intraoperative soft tissue tension to determine the optimal position of ...
Richard Steer, Beth Tippett, R. Nazim Khan, Dermot Collopy, Gavin Clark   +4 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Verification of a dynamic knee simulator computational model [PDF]

, 2008
Dynamic knee simulators aim to reproduce prescribed physiological loading and motions of the knee. The natural knee achieves stability through a complex interaction of the neuro-musculoskeletal system; thus, a knee simulator also requires a sophisticated
Taylor, M, Reeve, A.N., Maletsky, L.P., Strickland, A.M.   +3 more
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Knee adduction moment and medial contact force - facts about their correlation during gait [PDF]

, 2013
The external knee adduction moment is considered a surrogate measure for the medial tibiofemoral contact force and is commonly used to quantify the load reducing effect of orthopedic interventions. However, only limited and controversial data exist about
Bergmann, Georg, Georg Bergmann, Adam Trepczynski, Markus O Heller, Kutzner, Ines, Trepczynski, Adam, Heller, Markus O., Ines Kutzner   +7 more
core   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis [PDF]

, 2011
Objective To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 ( TRPV1 ) is associated with genetic risk of painful knee osteoarthritis (OA). Methods The Ile585Val TRPV1 variant encoded
K. R. Muir, Lories, RJ, C. Cooper, Hart, DJ, D. J. Hart, W. Zhang, Dennison, Elaine M., Arden, Nigel, S. A. Doherty, Chapman, Victoria, Cicuttini, FM, Valdes, Ana M., Doherty, Sally A., Muir, Kenneth R., Vaughn, Frances L., T. D. Spector, Zhang, Weiya, Laslett, LL, Doherty, SA, Arden, N., Lories, Rik J., Chapman, V, Jones, Graeme, A. Soni, Muir, KR, P. Leaverton, V. Chapman, Leaverton, Paul, Spector, T. D., Arden, Nigel K., Jones, G, Cicuttini, Flavia M., Wilde, Gert De, Muir, Kenneth, Doherty, M, G. Jones, Hart, Deborah J., Wheeler, M, R. A. Maciewicz, Leaverton, P, Cooper, Cyrus, N. K. Arden, Valdes, AM, G. De Wilde, Arden, NK, Laslett, Laura L., Vaughn, FL, F. L. Vaughn, De Wilde, G, Zhang, W, A. M. Valdes, Maciewicz, Rose A., Maciewicz, RA, Spector, Tim D., Wheeler, Margaret, Dennison, EM, Spector, TD, M. Doherty, Cooper, C, R. J. Lories, M. Wheeler, Soni, Anushka, E. M. Dennison, F. M. Cicuttini, L. L. Laslett, De Wilde, Gert, Soni, A, Hart, Deborah J.; id_orcid, Doherty, Michael   +68 more
core   +1 more source

Molecular diagnostics for perioperative microbial identification in periprosthetic joint infection: A scoping review and proposal of a diagnostic flow chart

Journal of Experimental Orthopaedics
Purpose Periprosthetic joint infections (PJI) are among the most feared complications of joint reconstruction. Unfortunately, traditional cultures often fail to identify the aetiological agents of PJI.
Pier Francesco Indelli, Trifon Totlis, Bruno Lovreković, Michael Engl, Bruno Violante, Pawel Skowronek, Guillaume Demey, Stefano Ghirardelli, Chiara Maci, Antonella Castagna, Laura Schianchi, Chiara Tassan Din, James Harty, Goksel Dikmen, Christian Schaller, Marko Ostojić   +15 more
doaj   +1 more source

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source