Results 91 to 100 of about 1,203,650 (246)

Prevalence, functional impact, and associated factors of knee osteoarthritis and knee pain among adults in Urumqi, Northwest China: a community-based cross-sectional study

Frontiers in Public Health
BackgroundKnee osteoarthritis and knee pain are major causes of chronic pain, functional limitation, and health-care use, but community-level evidence on their symptomatic burden and associated factors remains limited in northwest China.
Lingyun Shi, Lingyun Shi, Siqi Li, Jiaju Zhao, Guoliang Hou, Abiding Abulaiti, Xiaomin Lin, Haitao Zhang, Palida Maimaiti   +8 more
doaj   +1 more source

Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians.

PLoS ONE, 2019
Knee pain is often underreported, underestimated and undertreated. This study was conducted to estimate the prevalence, burden and further identify socioeconomic factors influencing ethnic differences in knee pain and symptoms of OA among older adults ...
Sumaiyah Mat, Mohamad Hasif Jaafar, Chin Teck Ng, Sargunan Sockalingam, Jasmin Raja, Shahrul Bahyah Kamaruzzaman, Ai-Vyrn Chin, Azlina Amir Abbas, Chee Ken Chan, Noran Naqiah Hairi, Sajaratulnisah Othman, Robert G Cumming, Nai Peng Tey, Maw Pin Tan   +13 more
doaj   +1 more source

Psychological health is associated with knee pain and physical function in patients with knee osteoarthritis: an exploratory cross-sectional study

BMC Psychology, 2018
Background Depressive symptoms are a major comorbidity in older adults with knee osteoarthritis (OA). However, the type of activity-induced knee pain associated with depression has not been examined.
Hirotaka Iijima, Tomoki Aoyama, Naoto Fukutani, Takuya Isho, Yuko Yamamoto, Masakazu Hiraoka, Kazuyuki Miyanobu, Masashi Jinnouchi, Eishi Kaneda, Hiroshi Kuroki, Shuichi Matsuda   +10 more
doaj   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Association between constant and intermittent knee pain and T2 values and cartilage thickness: data from the osteoarthritis initiative

Arthritis Research & Therapy
Background We investigated whether cartilage composition and thickness and its change over time were associated with future intermittent and constant knee pain.
Maximilian T. Löffler, Gabby B. Joseph, John A. Lynch, Nancy E. Lane, Valentina Pedoia, Sharmila Majumdar, Michael Nevitt, Charles McCulloch, Thomas M. Link   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Bone marrow lesion coexisted with subchondral bone attrition and/or subchondral bone cyst is associated with knee pain in knee osteoarthritis regardless of cartilage lesion: the Bunkyo health study

Arthritis Research & Therapy
Background Subchondral bone changes, which include bone marrow lesion (BML), subchondral bone attrition (SBA) and subchondral bone cyst (SBC) by magnetic resonance imaging (MRI) analysis, are reportedly implicated for knee pain in knee osteoarthritis (OA)
Jun Tomura, Haruka Kaneko, Arepati Adili, Takako Aoki, Lizu Liu, Yoshifumi Negishi, Keiichi Yoshida, Keiji Kobayashi, Suguru Wakana, Shinnosuke Hada, Jun Shiozawa, Yuichiro Machiyama, Takuya Yamamura, Takahiro Sasahara, Kengo Sugitani, Mitsuaki Kubota, Yuki Someya, Yoshifumi Tamura, Shuko Nojiri, Takako Negishi-Koga, Yasunori Okada, Muneaki Ishijima   +21 more
doaj   +1 more source

Web-Based Study of Risk Factors for Pain Exacerbation in Osteoarthritis of the Knee (SPARK-Web): Design and Rationale

JMIR Research Protocols, 2015
BackgroundKnee osteoarthritis (OA) is the most frequent cause of limited mobility and diminished quality of life. Pain is the main symptom that drives individuals with knee OA to seek medical care and a recognized antecedent to disability and eventually
Makovey, Joanna, Metcalf, Ben, Zhang, Yuqing, Chen, Jian Sheng, Bennell, Kim, March, Lyn, Hunter, David J   +6 more
doaj   +1 more source

TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care: A randomised controlled trial with patient preference study. [ISRCTN79353052] [PDF]

, 2005
Background: Many older people have chronic knee pain. Both topical and oral non- steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat this.
Spencer, Anne E., Hennessy, Enid M., Cross Pamela L, Spencer, AE, Ashby Deborah, Harding, G, Enid M Hennessy, Anne E Spencer, Harding Geoff, Parsons Suzanne, Underwood, Martin, Letley Louise, Letley, Louise, Martin Underwood, Underwood Martin, TOIB Study Team, Louise Letley, Hennessy Enid M, Underwood, M, Hennessy, EM, Spencer Anne E, Ashby, D, Suzanne Parsons, null null, Cross, Pamela L., Pamela L Cross, Ashby, Deborah, Geoff Harding, Deborah Ashby, Cross, PL, Harding, Geoff, Parsons, Suzanne, Parsons, S, Letley, L   +33 more
core   +2 more sources

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source