Results 91 to 100 of about 480,132 (361)

Evaluation of efficacy of proximal fibular osteotomy in predominantly medial compartment osteoarthritis of knee for pain relief and improvement in medial joint space of the knee [PDF]

, 2020
Pramod Sunda, AK Mathur, SP Gupta, R S Verma, Mohit Kumar, Narendra Singh   +5 more
openalex   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Psychological health is associated with knee pain and physical function in patients with knee osteoarthritis: an exploratory cross-sectional study

BMC Psychology, 2018
Background Depressive symptoms are a major comorbidity in older adults with knee osteoarthritis (OA). However, the type of activity-induced knee pain associated with depression has not been examined.
Hirotaka Iijima, Tomoki Aoyama, Naoto Fukutani, Takuya Isho, Yuko Yamamoto, Masakazu Hiraoka, Kazuyuki Miyanobu, Masashi Jinnouchi, Eishi Kaneda, Hiroshi Kuroki, Shuichi Matsuda   +10 more
doaj   +1 more source

Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort [PDF]

, 2018
This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain threshold
Akin-Akinyosoye, Kehinde, Doherty, Michael, Ferguson, Eamonn, Fernandes, Gwen Sascha, Frowd, Nadia, Marshall, Laura, McWilliams, Daniel F., Stocks, Joanne, Valdes, Ana M., Walsh, David A., Zhang, Weiya   +10 more
core   +4 more sources

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Association between constant and intermittent knee pain and T2 values and cartilage thickness: data from the osteoarthritis initiative

Arthritis Research & Therapy
Background We investigated whether cartilage composition and thickness and its change over time were associated with future intermittent and constant knee pain.
Maximilian T. Löffler, Gabby B. Joseph, John A. Lynch, Nancy E. Lane, Valentina Pedoia, Sharmila Majumdar, Michael Nevitt, Charles McCulloch, Thomas M. Link   +8 more
doaj   +1 more source

Techniques for assessing knee joint pain in arthritis

Molecular Pain, 2007
The assessment of pain is of critical importance for mechanistic studies as well as for the validation of drug targets. This review will focus on knee joint pain associated with arthritis. Different animal models have been developed for the study of knee
Fu Yu, Adwanikar Hita, Han Jeong S, Neugebauer Volker, Ji Guangchen   +4 more
doaj   +1 more source

Relationships between post operative pain management and short term functional mobility in total knee arthroplasty patients with a femoral nerve catheter: A preliminary study [PDF]

, 2011
Background: Effective pain management following total knee arthroplasty (TKA) is fundamental in achieving positive rehabilitation outcomes. The purpose of our study was to investigate post operative pain management in relation to short term functional ...
Fetherston, C., Ward, S.
core   +3 more sources

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians.

PLoS ONE, 2019
Knee pain is often underreported, underestimated and undertreated. This study was conducted to estimate the prevalence, burden and further identify socioeconomic factors influencing ethnic differences in knee pain and symptoms of OA among older adults ...
Sumaiyah Mat, Mohamad Hasif Jaafar, Chin Teck Ng, Sargunan Sockalingam, Jasmin Raja, Shahrul Bahyah Kamaruzzaman, Ai-Vyrn Chin, Azlina Amir Abbas, Chee Ken Chan, Noran Naqiah Hairi, Sajaratulnisah Othman, Robert G Cumming, Nai Peng Tey, Maw Pin Tan   +13 more
doaj   +1 more source