Results 101 to 110 of about 1,203,650 (246)

Techniques for assessing knee joint pain in arthritis

Molecular Pain, 2007
The assessment of pain is of critical importance for mechanistic studies as well as for the validation of drug targets. This review will focus on knee joint pain associated with arthritis. Different animal models have been developed for the study of knee
Fu Yu, Adwanikar Hita, Han Jeong S, Neugebauer Volker, Ji Guangchen   +4 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Optimal Tai Chi forms in knee osteoarthritis: An exploration from biomechanical rationale to pain reductionSignificance and Innovations:

Osteoarthritis and Cartilage Open
Objectives: Tai Chi (TC) shows some beneficial effects in reducing pain in knee osteoarthritis (OA). However, the selection of criteria TC forms in previous studies were unclear and inconsistent, possibly accounting for the varying outcomes and rendering
Feng Yang, Jonathan Gelfond, Donald McGeary, Allen Perkins, Alison A. Moore, Lixin Song, Agustín Escalante, Wei Liu   +7 more
doaj   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Painful knees [PDF]

Postgraduate Medical Journal, 2002
S, Batra, L, Maini, A, Upadhyay, B K, Dhaon   +3 more
openaire   +2 more sources

Referral recommendations for osteoarthritis of the knee incorporating patients' preferences [PDF]

, 2010
Background. GPs have to respond to conflicting policy developments. As gatekeeper they are supposed to manage the growing demand for specialist services and as patient advocate they should be responsive to patients' preferences.
McCaskie, Andrew W, Musila, Nyokabi, Nyokabi Musila, McCaskie, A. W., Andrew W McCaskie, Musila, N., van der Meulen, Jan H, Meulen, J. H. van der, Jan H van der Meulen, Nick Black, Underwood, Martin, Martin Underwood, Aileen Clarke, Black, Nick, Black, N., Clarke, Aileen   +15 more
core   +1 more source

Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals

Advanced Science, EarlyView.
A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu, Sultan Mahmud, Mali Halac, Asif Iftekhar Omi, Domenica Sofia Baez Rodas, Jeremiasz Dados, Chaojun Cheng, Anyu Jiang, Cameron Wallace, Anvi Singh, Erin Patrick, Baibhab Chatterjee, Shriya Srinivasan, Adam Khalifa   +13 more
wiley   +1 more source

Painful knee [PDF]

Postgraduate Medical Journal, 1994
L, Kreel, M A, al-Kutoubi
openaire   +2 more sources

Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates

Advanced Science, EarlyView.
Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta, Julien Duclay, Robin Baurès, Andrea Alamia   +3 more
wiley   +1 more source

Does pain pattern matter? Association of intermittent, constant, predictable and unpredictable knee pain to patient-reported knee symptom acceptability in knee osteoarthritis

Osteoarthritis and Cartilage Open
Objective: People with knee osteoarthritis (OA) describe intermittent, constant, predictable, and unpredictable pain, but how different pain patterns affect symptom experience is unknown.
Gillian A. Hawker, Lisa Carlesso, Ian Stanaitis, Tuhina Neogi, Lauren K. King, Jean W. Liew   +5 more
doaj   +1 more source