Results 81 to 90 of about 201,509 (265)

Effect of knee orthosis on walking performance in individuals with knee osteoarthritis

Journal of Associated Medical Sciences, 2017
Background: Knee orthosis has been recommended as part of conservative treatment for individuals with knee osteoarthritis (OA). However, the effects of common types of knee orthosis on function and pain during movement are still inconclusive. Objective:
Amornthep Jankaew, Patraporn Sitilertpisan, Samatchai Chamnongkich   +2 more
doaj  

Painful knee [PDF]

Postgraduate Medical Journal, 2004
K, Selvarajan, R, Vadivelu, T P, Green
openaire   +2 more sources

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Mediating role of effusion-synovitis in knee pain worsening following quadriceps weakness: data from the osteoarthritis initiative

BMC Musculoskeletal Disorders
Objective The cause of increased knee pain related to quadriceps weakness in knee osteoarthritis remains unclear. This study aimed to assess the impact of alterations in the effusion-synovitis, a special kind of nociceptive structure, on changes in knee ...
Ze Gong, Di Ao, Tingni Li, Le Li
doaj   +1 more source

Frequency and Associated Factors of Knee and Low Back Pain among Adults with Pes Planus

Journal of the Dow University of Health Sciences, 2018
Objective: To determine the frequency and associated factors of knee and low back pain among adults with pes planus. Methods: This cross-sectional study was conducted in Hayatabad Medical Complex Peshawar, Pakistan from May 2017 to November 2017.
Sana Fatima, Aatik Arsh, Noor Rahman, Aman Ullah, Mahreen Gohar, Aftab Ahmad   +5 more
doaj   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Efficiency of Orthopaedic Brace with Laser on Knee Joint Function, Pain and Swelling

Baltic Journal of Sport and Health Sciences, 2018
Background. The effectiveness of outpatient mobile laser intervention on specific treatment goals has not been fully explored. Thus, the aim of the study was to examine the effect of orthopaedic knee brace with laser on knee joint function, pain and ...
Tomas Indriulionis, Juozas Raistenskis, Kęstutis Saniukas, Rūta Garšvienė, Viktorija Zacharenko, Viktoras Vaičikauskas, Sigitas Kamandulis, Audrius Sniečkus, Vida Janina Česnaitienė, Dovilė Kielė, Neringa Baranauskienė, Nerijus Eimantas, Rima Solianik, Mantas Mickevičius, Albertas Skurvydas, Vytautas Streckis, Renata Žumbakytė Šermukšnienė   +16 more
doaj   +1 more source

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, EarlyView.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source