Results 111 to 120 of about 4,847 (258)

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

Praxis-BGM: clustering of omics data using semi-supervised transfer learning for Gaussian mixture models via natural-gradient variational inference. [PDF]

Bioinformatics
Jia Q, Goodrich JA, Conti DV.
europepmc   +1 more source

Personalized machine learning prediction of next‐day migraine persistence using digital headache diary data

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Migraine is a disabling neurological disorder with substantial interindividual variability. Predicting whether an ongoing migraine attack will persist into the following day remains challenging. We evaluated the feasibility and predictive performance of personalized machine learning models for predicting next‐day migraine
Ya‐Hsiu Tsai, Chen‐Lin Chiou, Jun‐Jun Lee, Chun‐Ming Yang, Kao‐Chang Lin, Tain‐Junn Cheng, Ja‐Hwung Su, Cheng‐Hsin Chuang   +7 more
wiley   +1 more source

A stochastic approach to k-nearest neighbors search using a fixed radius method. [PDF]

Comput Stat
Cano Urrego B, Alsup A, Thompson JA, Koestler DC.   +3 more
europepmc   +1 more source

A Horse Race of Machine‐Learning Methods to Predict Banking Crises

International Finance, EarlyView.
ABSTRACT To examine if one machine‐learning model can consistently elucidate financial vulnerabilities, both over time and across levels of development, this paper applies 13 machine‐learning algorithms to evaluate comparative forecasting performance across several banking crises.
Emile du Plessis
wiley   +1 more source

EnergyRoute: energy-based uncertainty routing for selective retrieval and large language model assistance in the hierarchical classification of biotechnology R&D projects. [PDF]

Sci Rep
Jang G, Kim MW, Nam YJ, Yong Y, Lee KH, Lim C.   +5 more
europepmc   +1 more source

Mixing It Up: Inflation at Risk

Journal of Money, Credit and Banking, EarlyView.
Abstract Understanding how risk factors shape the economic outlook is essential for guiding policy decisions. This paper develops a flexible framework that decomposes distributional risk forecasts of macro‐economic variables into underlying contributions and supports the construction of interpretable risk measures.
MAXIMILIAN SCHRÖDER
wiley   +1 more source

AlleleMiner: a long-read pipeline for gene-wise de novo allele phasing and variant detection in diploid citrus cultivars. [PDF]

DNA Res
Kiryu Y, Kawahara Y, Endo T, Horiike T, Shirasawa K, Isobe S, Shimada T, Fujii H.   +7 more
europepmc   +1 more source

Heterodonty in the teeth of the turiasaurian sauropod from Angeac‐Charente (Early Cretaceous, southwestern France): Comparison of anatomical and geometric morphometric approaches

Journal of Anatomy, EarlyView.
Turiasaurian teeth from Angeac‐Charente exhibit five dental morphotypes and reveal clear heterodonty and anteroposterior size gradient. Qualitative comparative anatomy quickly and efficiently identifies morphotypes, while 3D geometric morphometrics combined with machine learning refine ambiguous cases, demonstrating that qualitative and quantitative ...
Clémence L. E. Gouellec, Ronan Allain, Jean Goedert, Romain Pintore, Jackson Carter, Rafael Royo‐Torres, Dominique Augier, Raphaël Cornette   +7 more
wiley   +1 more source