Results 131 to 140 of about 5,170 (214)

Big Data in Cancer Genomics: Computational Foundations and Emerging Pathways for Precision Oncology

open access: yesComputational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT This review aims to explore the computational foundations of big data in cancer genomics and examine emerging pathways that support precision oncology and personalized cancer care. A narrative review approach was adopted to synthesize evidence from PubMed, Scopus, Web of Science, and IEEE Xplore.
Nur Vanu   +8 more
wiley   +1 more source

HierAnom‐Path: Zero‐Shot Rare Cancer Detection in Histopathology via Hierarchical Foundation Model Adaptation

open access: yesComputational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Rare cancers collectively represent 20%–25% of all malignancies yet yield fewer than 50 annotated whole‐slide images (WSIs) per subtype in publicly available archives, rendering supervised deep learning inapplicable. We present HierAnom‐Path, to the best of our knowledge, the first framework for zero‐shot rare cancer anomaly detection in ...
Noora Saleem Jumaah   +5 more
wiley   +1 more source

Phenotype imputation using high‐throughput phenotyping produces a new secondary trait for further selection modeling

open access: yesThe Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Data from high‐throughput phenotyping (HTP) could be used for phenotype imputation to enhance genomic selection (GS) or gene discovery, but this has not been explored in crop species. Three machine learning models: multiple linear regression (MLR), missForest, and k‐nearest neighbors, were evaluated for grain yield (GY) phenotype imputation in
Raysa Gevartosky   +2 more
wiley   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1326-1337, November 2026.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries   +8 more
wiley   +1 more source

EmmaEmb: A quantitative framework for analyzing embedding spaces in molecular biology. [PDF]

open access: yesPatterns (N Y)
Rissom PF   +7 more
europepmc   +1 more source

Müller Glia Subtypes Define Neuro‐Glial Associations and Spatial Morphogen Axes in the Zebrafish Retina

open access: yesGlia, Volume 74, Issue 11, November 2026.
Zebrafish Müller glia are heterogeneous in the early larval retina. Zebrafish Müller glia subtypes define a spatial axis of retinoic acid metabolism. Neuron‐associated glial programs identified in Zebrafish Müller glia are evolutionarily conserved in mammals. ABSTRACT Müller glia are instrumental macroglia of the vertebrate retina, once thought to be a
Samuel S. Storey   +3 more
wiley   +1 more source

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