Results 161 to 170 of about 1,849,891 (275)

Development and application of a mechanistic model for protein A resolution of a bispecific antibody for process characterization and optimization

open access: yesBiotechnology Progress, EarlyView.
Abstract Regeneron's bispecific technology, based on a fully human IgG antibody construct, consists of two distinct heavy chains and a common light chain co‐expressed in a single cell. The co‐expression of the two distinct heavy chains, one of which contains a dipeptide substitution that ablates Protein A binding, leads to the formation of three ...
Samantha Wadsworth   +4 more
wiley   +1 more source

ALCAM is an entry factor for severe community acquired Pneumonia-associated Human adenovirus species B

open access: yesNature Communications
Human adenovirus (HAdV) is a widely spread respiratory pathogen that can cause infections in multiple tissues and organs. Previous studies have established an association between HAdV species B (HAdV-B) infection and severe community-acquired pneumonia ...
Yusang Xie   +8 more
doaj   +1 more source

Bond Formation: Shaken, Not Stirred

open access: yesChemistry – A European Journal, EarlyView.
Shaking of seismo‐molecules efficiently transforms kinetic energy into storable chemical potential, unlocking high‐utility Gibbs free energy. This innovative mechanism pioneers uncharted scientific frontiers, introducing fascinating phenomena like seismochemistry, seismochromism, and seismofluorescence that redefine the boundaries of molecular ...
Alexander D. Q. Li
wiley   +1 more source

Nitrogen‐Site Isomerism Unlocks Exciton Dissociation in Vinylene‐Linked COF‐Based Photocatalysts

open access: yesEcoEnergy, EarlyView.
Two regioisomeric vinylene‐linked covalent organic frameworks (COFs) constructed from diazine units with different nitrogen positions are developed for photocatalytic hydrogen evolution reaction (HER). Although structurally similar, the isomeric COFs exhibit distinct electron distribution and charge‐separation behaviors, leading to a more than twofold ...
Ming Wang   +10 more
wiley   +1 more source

A Mixed‐Ligand Metal–Organic Framework Strategy to Construct High‐Density O/S‐Shelled Ag Nanoparticle Electrocatalysts for Syngas Modulation

open access: yesEcoEnergy, EarlyView.
Mixed‐ligand Ag–triazole MOF precursors reconstruct into ligand‐shelled Ag nanoparticle electrocatalysts that retain detectable O/S‐derived interfacial species. By combining ligand‐ratio and potential control, the CO2‐to‐syngas output can be tuned across H2‐rich, near‐equimolar, and CO‐rich regimes.
Ren‐Feng Yang   +12 more
wiley   +1 more source

Confined Hot Carrier Cooling Via Excited‐State Energy Gap Engineering in Graphyne Carbon Allotropes

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The excited‐state energy gap (EEG), regulated by the concentration of sp‐hybridized carbon, provides an effective handle for tuning electron–phonon coupling behavior. This design enables long‐lived confinement of hot carriers near the top of the EEG with controllable energy levels.
Fulong Dai   +9 more
wiley   +1 more source

When AI Remembers: Investigating the Dual Role of Long‐Term Memory in Chatbots

open access: yesPsychology &Marketing, EarlyView.
ABSTRACT This research investigates the dual role of long‐term memory (LTM) in AI chatbots and its impact on customer outcomes. Drawing on Mind Perception Theory and Privacy Calculus Theory, we conceptualize LTM as a continuity‐based design capability that may be interpreted as a functional service feature, a privacy‐relevant cue, or a basis for ...
Maedeh Parvizian   +4 more
wiley   +1 more source

Author response: The allosteric modulation of complement C5 by knob domain peptides

open access: yes, 2020
Alex Macpherson   +17 more
openaire   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu   +5 more
wiley   +1 more source

Cross‐Scale Engineering of Single‐Atom Catalysts from Local Planar Coordination to Spatial Architectures

open access: yesSmall, EarlyView.
This Review presents a cross‐scale framework for single‐atom catalysts, spanning in‐plane and out‐of‐plane coordination; primary coordination, secondary‐sphere interactions, through‐space microenvironments and support interfaces; individual sites and macroscopic architectures; and static design and directed dynamic reconstruction.
Dazhi Yao   +4 more
wiley   +1 more source

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