A Novel Recombinant FAdV-4 Virus with Fiber of FAdV-8b Provides Efficient Protection against Both FAdV-4 and FAdV-8b [PDF]
Viruses, 2022 Since 2015, the outbreaks of hydropericardium-hepatitis syndrome (HHS) and inclusion body hepatitis (IBH) caused by the highly pathogenic serotype 4 fowl adenovirus (FAdV-4) and serotype 8 fowl adenovirus (FAdV-8), respectively, have caused huge economic
Aijian Qin, Hao Lu, Tuofan Li
exaly +8 more sources
FAdV-4 Promotes Expression of Multiple Cytokines and Inhibits the Proliferation of aHEV in LMH Cells [PDF]
Viruses, 2023 Single or mixed infections of multiple pathogens such as avian hepatitis E virus (aHEV) and avian leukosis virus subgroup J (ALV-J) have been detected in numerous laying hens with severe liver injury in China. Thus, aHEV and immunosuppressive viruses are
Lidan Hou +5 more
doaj +5 more sources
FAdV-4 without Fiber-2 Is a Highly Attenuated and Protective Vaccine Candidate [PDF]
Microbiology Spectrum, 2022 Hepatitis-hydropericardium syndrome (HHS) caused by the highly pathogenic fowl adenovirus serotype 4 (FAdV-4) has resulted in huge economic losses to the poultry industry globally.
Aijian Qin, Wei Gao, Tuofan Li
exaly +6 more sources
FAdV-4 induces more severe inflammatory responses compared to FAdV-8b [PDF]
Poultry ScienceMultiple infections, either single or mixed, involving pathogens such as serotype 4 fowl adenovirus (FAdV-4) and serotype 8b fowl adenovirus (FAdV-8b), have been observed in numerous laying hens in China, leading to severe liver damage.
Sidang Liu, Zilong Cheng, Qinqin Sun
exaly +7 more sources
Efficient cross-protection against serotype 4/8a fowl adenoviruses (FAdVs): recombinant FAdV-4 with FAdV-8a Fiber [PDF]
Microbiology Spectrum, 2023 Recently, the infection of fowl adenoviruses (FAdVs) in chicken flocks has caused huge economic losses to the poultry industry in China. Although immunization with Fiber protein can provide autogenous protection of FAdVs, no commercial multivalent ...
Aijian Qin, Tuofan Li, Jianqiang Ye
exaly +6 more sources
FAdV-4 can cause more noticeable clinical symptoms compared to FAdV-8b after infecting specific pathogen free chickens [PDF]
Poultry Science: Chickens infected with FAdV-4 and FAdV-8b both exhibit hepatic lesions characterized by hemorrhagic necrosis and intranuclear inclusion body formation. However, only FAdV-4 induces pericardial effusion and acute mortality in chickens.
Sidang Liu, Qinqin Sun
exaly +6 more sources
Hypervirulent FAdV-4 infection induces activation of the NLRP3 inflammasome in chicken macrophages [PDF]
Poultry Science, 2022 : Fowl adenovirus serotype 4 (FAdV-4) is the primary causative agent of hepatitis–hydropericardium syndrome (HHS) causing great economic losses to the world poultry industry. The exact factors responsible for the pathogenesis of hypervirulent FAdV-4 have
Baiyu Wang +10 more
doaj +4 more sources
Prevalence and Molecular Characterization of FAdV-4 Isolated in Fujian Province, Southeast China During 2023-2025. [PDF]
Transbound Emerg DisFowl adenovirus (FAdV) serotype 4 (FAdV‐4) is a significant pathogen causing hepatitis–hydropericardium syndrome (HHS) in poultry, which can cause severe economic losses to the global poultry industry. Molecular epidemiological investigation of FAdV‐4 has not been conducted in Fujian province, southeast China. In this study, we collected 219 samples of
Chen Y +9 more
europepmc +3 more sources
An inactivated novel chimeric FAdV-4 containing fiber of FAdV-8b provides full protection against hepatitis-hydropericardium syndrome and inclusion body hepatitis [PDF]
Veterinary Research, 2022 Fowl adenovirus serotype 4 (FAdV-4) and FAdV-8b are causative agents of hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH), respectively.
Baiyu Wang +9 more
doaj +2 more sources
Coinfection with fowl adenovirus serotypes 1 and 4 (FAdV-1 and -4) enhances FAdV-4 replication through FAdV-1-mediated upregulation of HSPA2 expression [PDF]
VirulenceFowl adenoviruses (FAdVs) are widely distributed in poultry populations around the world, and many diseases are associated with FAdV infection in chickens.
Xiaoxuan Li +10 more
doaj +2 more sources