Results 1 to 10 of about 9,294,284 (160)

Fowl Adenovirus 4 (FAdV-4)-Based Infectious Clone for Vaccine Vector Development and Viral Gene Function Studies [PDF]

Viruses, 2018
Fowl adenovirus 4 (FAdV-4) is associated with economically important poultry diseases. Recent studies of fully sequenced genomes of FAdV-4 isolates suggest potential genomic regions associated with virulence and amenable for manipulation and vector development.
Yanlong Pei, Juan Corredor, Bryan Griffin, Peter Krell, Éva Nagy   +4 more
openaire   +4 more sources

Genetic modification regulates pathogenicity of a fowl adenovirus 4 strain after cell line adaptation (genetic mutation in FAdV-4 lowered pathogenicity) [PDF]

Heliyon, 2023
Fowl adenovirus 4 (FAdV-4) is a major avian virus that induces fatal diseases in chicken such as, hydropericardium and hepatitis. The viral structure consists of hexon, penton, fiber-1, and fiber-2 which are associated with immunopathogenesis. In this study, we investigated the genetic modification of a FAdV-4 strain after continuous passages in a cell
Ji-in Yeo, Rangyeon Lee, Haneul Kim, Somin Ahn, Jeongho Park, Haan Woo Sung   +5 more
openaire   +4 more sources

The fowl adenovirus serotype 4 (FAdV-4) induce cellular pathway in chickens to produce interferon and antigen-presented molecules (MHCI/II) [PDF]

Poultry Science, 2021
FAdV-4 is the major strain of adenovirus that responsible for hydro-pericardial syndrome (HPS) in poultry. In this study, the virus's specific gene fragments were isolated from clinically suspected cases and amplified by PCR. Finally, after a viral infection to investigate the immune response of the host, the gene expression of MHC (major histo ...
Meizhen Li, Muhammad Akmal Raheem, Chunyang Han, Fengmei Yu, Yin Dai, Muhammad Imran, Qin Hong, Jun zhang, Yang Tan, Lisha Zha, Fangfang Chen   +10 more
openaire   +4 more sources

Differential innate immune responses to fowl adenovirus serotype 4 infection in Leghorn male hepatocellular and chicken embryo fibroblast cells

Poultry Science
: Fowl adenovirus serotype 4 (FAdV-4) infections result in substantial economic losses in the poultry industry. Recent findings have revealed that FAdV-4 significantly suppresses the host immune response upon infection; however, the specific viral and ...
Xiaolan Hou, Lizhen Wang, Riteng Zhang, Gen Liu, Ting Wang, Bo Wen, Wenchi Chang, Shuizhong Han, Jinjie Han, Junyang Fang, Xuefeng Qi, Jingyu Wang   +11 more
doaj   +2 more sources

Fiber-2, not Fiber-1, is the principal protective immunogen of fowl adenovirus serotype 4: insights from a comparative efficacy study of chimeric virus-based inactivated vaccines [PDF]

Poultry Science
Fowl adenovirus serotype 4 (FAdV-4) uniquely encodes two fiber proteins (fiber-1 and fiber-2), while FAdV-8b possesses only one. Although our previous study showed that an inactivated vaccine based on a chimeric virus with FAdV-4′s fiber-1 replaced by ...
Panpan Yang, Mengjia Xiang, Minghe Xu, Yutao Zhu, Luyao Qiu, Muran Xu, Bingjie Zhang, Yaru Zhang, Jin Qiu, Dongdong Yang, Qilong Qiao, Yanfang Cong, Baiyu Wang, Jianli Li, Jun Zhao   +14 more
doaj   +2 more sources

Identification of chicken CAR homology as a cellular receptor for the emerging highly pathogenic fowl adenovirus 4 via unique binding mechanism

Emerging Microbes and Infections, 2020
Since 2015, the prevalence of severe hepatitis-hydropericardium syndrome, which is caused by the novel genotype fowl adenovirus serotype 4 (FAdV-4), has increased in China and led to considerable economic losses.
Qing Pan, Jing Wang, Yulong Gao, Qi Wang, Hongyu Cui, Changjun Liu, Xiaole Qi, Yanping Zhang, Yongqiang Wang, Kai Li, Li Gao, Aijing Liu, Xiaomei Wang   +12 more
doaj   +1 more source

An Efficient and Rapid Assay for Detecting Neutralizing Antibodies Against Serotype 4 Fowl Adenovirus

Frontiers in Veterinary Science, 2022
Currently, the outbreak of serotype 4 fowl adenovirus (FAdV-4) has spread worldwide and caused tremendous economic loss to the poultry industry. Although inactivated vaccines have been licensed against FAdV-4 in China, a rapid and efficient serological ...
Yiwen Guo, Yiwen Guo, Yiwen Guo, Yiwen Guo, Songhua Xie, Songhua Xie, Songhua Xie, Songhua Xie, Zhenqi Xu, Zhenqi Xu, Zhenqi Xu, Zhenqi Xu, Quan Xie, Quan Xie, Quan Xie, Quan Xie, Weikang Wang, Weikang Wang, Weikang Wang, Weikang Wang, Zhimin Wan, Zhimin Wan, Zhimin Wan, Zhimin Wan, Tuofan Li, Tuofan Li, Tuofan Li, Tuofan Li, Aijian Qin, Aijian Qin, Aijian Qin, Aijian Qin, Hongxia Shao, Hongxia Shao, Hongxia Shao, Hongxia Shao, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye   +39 more
doaj   +1 more source

Transcriptome Analysis Reveals the Potential Role of Long Noncoding RNAs in Regulating Fowl Adenovirus Serotype 4-Induced Apoptosis in Leghorn Male Hepatocellular Cells

Viruses, 2021
Hepatitis-hydropericardium syndrome (HHS) is caused by fowl adenovirus serotype 4 (FAdV-4) and has resulted in considerable economic losses to the poultry industry globally. FAdV-4 elicits apoptosis in host cells.
Bo Wen, Xueping Wang, Lulu Yang, Ting Wang, Xiaolan Hou, Xuefeng Qi, Jingyu Wang   +6 more
doaj   +1 more source

Immune protection efficacy of FAdV-4 surface proteins fiber-1, fiber-2, hexon and penton base

Virus Research, 2018
The spread of hydropericardium syndrome has recently become serious in China since 2015. There is, therefore, an urgent need for new, safe and effective vaccines that prevent the disease. Here, the immune protection induced by Escherichia coli-expressed capsid proteins of fowl adenovirus serotype 4, including fiber-1, fiber-2, penton base and hexon ...
Xinglong, Wang, Qiuxia, Tang, Zhili, Chu, Peixin, Wang, Chen, Luo, Yajie, Zhang, Xiaoyu, Fang, Li, Qiu, Ruyi, Dang, Zengqi, Yang   +9 more
openaire   +2 more sources

Analysis of Fowl Adenovirus 4 Transcriptome by De Novo ORF Prediction Based on Corrected Nanopore Full-Length cDNA Sequencing Data

Viruses, 2023
The transcriptome of fowl adenovirus has not been comprehensively revealed. Here, we attempted to analyze the fowl adenovirus 4 (FAdV-4) transcriptome by deep sequencing.
Zhuozhuang Lu, Yongjin Wang, Xiaohui Zou, Tao Hung   +3 more
doaj   +1 more source