An inactivated novel chimeric FAdV-4 containing fiber of FAdV-8b provides full protection against hepatitis-hydropericardium syndrome and inclusion body hepatitis [PDF]
Veterinary Research, 2022 Fowl adenovirus serotype 4 (FAdV-4) and FAdV-8b are causative agents of hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH), respectively.
Baiyu Wang +9 more
doaj +2 more sources
Pathogenicity of an FAdV-4 isolate to chickens and its genomic analysis [PDF]
Journal of Zhejiang University-SCIENCE B, 2019 Fowl adenovirus serotype 4 (FAdV-4) strain SD1511 was isolated from chickens with severe inclusion body hepatitis and hydropericardium syndrome in Shandong Province, China. The isolate was cultured in primary chicken embryo kidney cells. A study of pathogenicity indicated that SD1511 readily infected 7-35-d-old chickens by intramuscular injection and ...
Kai-kun Mo +8 more
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Coinfection with fowl adenovirus serotypes 1 and 4 (FAdV-1 and -4) enhances FAdV-4 replication through FAdV-1-mediated upregulation of HSPA2 expression [PDF]
VirulenceFowl adenoviruses (FAdVs) are widely distributed in poultry populations around the world, and many diseases are associated with FAdV infection in chickens.
Xiaoxuan Li +10 more
doaj +2 more sources
Transcriptome analysis reveals critical factors for survival after adenovirus serotype 4 infection
Poultry Science, 2023 : Fowl adenovirus serotype-4 (FAdV-4) is highly lethal to poultry, making it one of the leading causes of economic losses in the poultry industry. However, a small proportion of poultry can survive after FAdV-4 infection.
Yuhang Zhou +14 more
doaj +2 more sources
TMT-based quantitative proteomics analysis reveals the role of Notch signaling in FAdV-4-infected LMH cell [PDF]
Frontiers in Microbiology, 2022 Fowl adenovirus serotype 4 (FAdV-4) is recognized as a pathogen that causes hydropericardium syndrome. Irrespective of the pathway used by the virus to invade the chicken, the pathological characteristics of the disease include degeneration and necrosis of hepatocytes, formation of intranuclear inclusions, as well as inflammatory cell infiltration ...
Yujuan Niu +5 more
openaire +4 more sources
Infection, Genetics and Evolution, 2022 The prevalence of poultry adenovirus in China is determined using clinical diagnosis, molecular biological testing, serological testing, and LMH cell virus isolation. These methods can track and test key poultry and waterfowl breeding areas across the country. From 2015 to 2021, 9613 suspected adenovirus samples were collected from 28 provinces.
Yanxiao Wang
exaly +3 more sources
Integrating Serological and Molecular Data to Characterize Fowl Adenovirus Associated With Inclusion Body Hepatitis in Broiler Chickens From Malaysia [PDF]
Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.This study revealed the active circulation of fowl adenoviruses in broiler farms in Sabah, Malaysia. FAdV‐8b and FAdV‐11 were identified in flocks with IBH lesions, accompanied by high antibody titres in unvaccinated birds. Phylogenetic analysis showed close relationships with global strains, highlighting the need for enhanced surveillance and control ...
Md. Safiul Alam Bhuiyan +5 more
wiley +2 more sources
Molecular characterization and phylogenetic analysis of fowl adenovirus serotype-4 from Guangdong Province, China [PDF]
Veterinary World, 2020 Aim: Our aim in this study was to isolate potentially novel strains of fowl adenovirus serotype-4 (FAdV-4) that is currently circulating in broiler chicken flocks in Guangdong Province, China, and to compare nucleotide and amino acid (AA) sequences of ...
Fu Yuming +12 more
doaj +2 more sources
Veterinary Research, 2018 A recent outbreak of hepatitis–hydropericardium syndrome caused by serotype 4 fowl adenovirus (FAdV-4) has resulted in significant economic losses to the poultry industry worldwide. However, little is known about the molecular pathogenesis of FAdV-4.
Ping Wang +8 more
doaj +2 more sources
Journal of Integrative Agriculture, 2019 Hepatitis-hydropericardium syndrome (HHS) is an infectious disease caused by fowl adenovirus serotype 4 (FAdV-4). Several structural and non-structural proteins of FAdV-4 have been expressed in Escherichia coli and baculovirus expression system to develop candidate subunit vaccines.
Jun-qin ZHANG +5 more
openaire +3 more sources