Results 41 to 50 of about 9,294,284 (160)

A novel monoclonal antibody differentiates highly pathogenic serotype 4 fowl adenovirus through targeting 188R in the Hexon

Poultry Science
Since 2015, hepatitis-hydropericardium syndrome (HHS) induced by the infection of highly pathogenic serotype 4 fowl adenovirus (HP-FAdV-4) has caused severe economic losses to the poultry industry.
Ye Tang, Bai Xie, Shi Liu, Quan Xie, Weikang Wang, Junpeng Chen, Xiaoyan Tian, Junji Gan, Tuofan Li, Shengnan Wang, Zhimin Wan, Hongxia Shao, Aijian Qin, Jianqiang Ye   +13 more
doaj   +2 more sources

Immunity analysis against Fowl Adenovirus serotype 4 (FAdV-4) based on Fiber-2 trimer Protein with the different virulence

Virus Research, 2022
Since June 2015, Fowl adenovirus outbreaks have occurred in China, causing significant economic losses to poultry industry. The FAdV-4 Fiber-2 proteins could induce effective protection, but the precise mechanism of immune protection remains unknown. Here, we have compared the biological characteristics of Fiber-2 protein of the very virulent WZ strain
Yapeng Song, Lin Liu
exaly   +3 more sources

Designing a Novel Multi-Epitope Trivalent Vaccine Against NDV, AIV and FAdV-4 Based on Immunoinformatics Approaches [PDF]

Microorganisms
The diseases caused by genotype VII Newcastle disease virus (NDV), H9N2 avian influenza virus (AIV), and fowl adenovirus serotype 4 (FAdV-4) continue to threaten the global poultry industry. However, no broad-spectrum vaccines provide simultaneous protection against these three pathogens.
Ji, Jiashuang, Dong, Xiaofeng, Liu, Xiangyi, Ding, Mengchun, Lin, Yating, Zhang, Yunhang, Zhang, Wuchao, Lei, Baishi, Yuan, Wanzhe, Zhao, Kuan   +9 more
openaire   +3 more sources

Identification, Pathogenicity of Novel Fowl Adenovirus Serotype 4 SDJN0105 in Shandong, China and Immunoprotective Evaluation of the Newly Developed Inactivated Oil-emulsion FAdV-4 Vaccine [PDF]

Viruses, 2019
Since mid-2015, numerous outbreaks of hydropericardium-hepatitis syndrome (HHS), which is caused by a novel fowl adenovirus serotype 4 (FAdV-4), have been reported in chickens in parts of China, thereby causing huge economic losses to the poultry ...
Wu Ai, Kai Meng, Xiaoyuan Yuan, Jiang Yu, Youling Wang, Yuxia Zhang   +5 more
core   +2 more sources

Immunogenicity of Novel Live Vaccine Based on an Artificial rHN20 Strain against Emerging Fowl Adenovirus 4

Viruses, 2021
In recent years, hepatitis-hydropericardium syndrome (HHS), caused by novel fowl adenovirus 4 (FAdV-4), has caused serious economic losses to the poultry industry. Vaccines are important for preventing and controlling HHS. Current FAdV-4 vaccine research
Yu Zhang, Qing Pan, Rongrong Guo, Aijing Liu, Zhuangzhuang Xu, Yulong Gao, Hongyu Cui, Changjun Liu, Xiaole Qi, Yanping Zhang, Kai Li, Li Gao, Xiaomei Wang   +12 more
doaj   +2 more sources

A Novel Composite Vaccine Combining Inactivated Antigen and IgY Elicits Sustained Humoral Immunity Against FAdV-4 Viruses and PEDV Viruses [PDF]

Viruses
Vaccination remains the primary strategy for controlling infectious diseases in farm animals. However, current conventional vaccines demonstrate clinical limitations including suboptimal immunogenicity and frequent booster requirements, which compromise disease management efficacy.
Wenming Gao, Zongmei Huang, Lin Liu, Lijie Li, Huimin Huang, Jingrui Liu, Wenwen Zhou, Yapeng Song, Xinsheng Li   +8 more
openaire   +3 more sources

Genetic characterization of novel fowl aviadenovirus 4 isolates from outbreaks of hepatitis-hydropericardium syndrome in broiler chickens in China

Emerging Microbes and Infections, 2016
Since May 2015, severe outbreaks of hepatitis-hydropericardium syndrome (HHS) associated with infections of fowl aviadenovirus (FAdV) have emerged in broiler chickens in several Chinese provinces.
Yanke Liu, Wenyan Wan, Dongsheng Gao, Yongtao Li, Xia Yang, Hongying Liu, Huixia Yao, Lu Chen, Chuanqing Wang, Jun Zhao   +9 more
doaj   +2 more sources

Biological features of fowl adenovirus serotype-4 [PDF]

Frontiers in Cellular and Infection Microbiology
Fowl adenovirus serotype 4 (FAdV-4) is highly pathogenic to broilers aged 3 to 5 weeks and has caused considerable economic loss in the poultry industry worldwide.
Farooq Rashid, Farooq Rashid, Farooq Rashid, Zhixun Xie, Zhixun Xie, Zhixun Xie, You Wei, You Wei, You Wei, Zhiqin Xie, Zhiqin Xie, Zhiqin Xie, Liji Xie, Liji Xie, Liji Xie, Meng Li, Meng Li, Meng Li, Sisi Luo, Sisi Luo, Sisi Luo   +20 more
doaj   +2 more sources

Mechanistic insights into the kidney injury in chickens induced by hypervirulent fowl adenovirus serotype 4

Microbiology Spectrum
Hypervirulent fowl adenovirus serotype 4 (FAdV-4) has emerged as a significant poultry pathogen since 2015, exhibiting clinical multi-organ and multi-tissue tropism post-infection, resulting in substantial economic losses in the poultry industry. However,
Chunhua Zhu, Jiayu Zhou, Zhen Chen, Cuiteng Chen, Ziyue Wang, Pei Yang, Guanghua Fu, Xiaodong Liu, Yu Huang, Chunhe Wan   +9 more
doaj   +2 more sources

Development of recombinant fowl adenovirus serotype 4 harboring the HiBiT-Tag reporter and its utility in antiviral research [PDF]

Microbiology Spectrum
Severe hydropericardium-hepatitis syndrome (HHS) caused by fowl adenovirus 4 (FAdV-4) significantly affects the global poultry industry. However, there is currently no convenient and sensitive platform available for the rapid screening of antiviral drugs
Xiaoran Guo, Cheng Li, Lingzhai Meng, Xiuli Li, Fuqiang Li, Lili Wang, Zhimin Dong, Qi Zhu, Huizhong Sun, Li Zhang, Minghua Yan   +10 more
doaj   +2 more sources