Results 111 to 120 of about 2,068 (144)

Insights Into the Conformational Dynamics of the Cytoplasmic Domain of Metal-Sensing Sensor Histidine Kinase ZraS. [PDF]

Proteins
Mahapatra N, Mahanta P, Pandey S, Acharya R.   +3 more
europepmc   +1 more source

Tracking and controlling ultrafast charge and energy flow in graphene-semiconductor heterostructures. [PDF]

Innovation (Camb)
Fu S, Zhang H, Tielrooij KJ, Bonn M, Wang HI.   +4 more
europepmc   +1 more source

Targeted FcRn to deliver epitope-optimized RBD confers broad-spectrum mucosal protection against SARS-CoV-2. [PDF]

Mol Ther Nucleic Acids
Chen X, Wu Y, Wang Y, Zhao C, Fang L, Zhu X, Lu J, Gao X, Zhang Z, Li H, Yan Y, Zhou P, Pan X.   +12 more
europepmc   +1 more source

Zero-Bias Photodetection and Opto-Synaptic Plasticity in BP/MoS₂ and WS₂/PdSe₂ van der Waals Heterostructures. [PDF]

ACS Appl Electron Mater
Durante O, Viscardi L, Mazzotti A, De Stefano S, Castellanos-Gomez A, Schleberger M, Di Bartolomeo A.   +6 more
europepmc   +1 more source

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Improved assembly of bispecific antibodies from knob and hole half-antibodies

Biotechnology Progress, 2015
A process was developed for large‐scale assembly of IgG 1 and IgG 4 bispecific antibodies from knob and hole half‐antibodies. We optimized assembly conditions such as pH, temperature, stabilizers, and reducing agent.
Glen Giese, Josefine Persson
exaly   +3 more sources

3D-Extraction of molecular surface knobs and holes for the study of complex formation

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 1992
A method for the visualization of knobs and holes in a molecular surface is presented here. After the calculation of the convex hull of the molecular surface, the global shape features, holes and knobs can be determined and visualized. This is the first stage of the docking problem.
Serge Hazout
exaly   +3 more sources

Bispecific antibody process development: Assembly and purification of knob and hole bispecific antibodies

Biotechnology Progress, 2018
Production of knob and hole dual light chain bispecific antibodies poses several unique challenges for development of a feasible industrial scale manufacturing process. We developed an efficient process for the assembly and purification of knob and hole dual light chain bispecific antibodies.
Glen Giese, Josefine Persson
exaly   +3 more sources

Proposed Knobs-Into-Holes Packing for Several Membrane Proteins

Membrane Biochemistry, 1978
We investigated the possible side chain/side chain interactions of four potential transmembrane proteins. The basic assumptions are that the proteins are alpha-helical, and that the proteins aggregate with knobs-into-holes packing. It was found that these four proteins can be assembled into stereochemically feasible bundles of alpha-helices with ...
A K, Dunker, T C, Jones
openaire   +2 more sources

Probing the Impact of the Knob-into-Hole Mutations on the Structure and Function of a Therapeutic Antibody

Analytical Chemistry, 2019
Bispecific antibodies (BsAbs) have drawn increasing interest in the biopharmaceutical industry due to their advantage to bind two distinct antigens simultaneously. The knob-into-hole approach is an effective way to produce bispecific antibodies by driving heterodimerization with mutations in the CH3 domain of each half antibody.
Peilu Liu, Xuan Gao, Victor Lundin, Catherine Shi, Yilma Adem, Kevin Lin, Guoying Jiang, Yung-Hsiang Kao, Feng Yang, David Michels, Alan G. Marshall, Hui-Min Zhang   +11 more
openaire   +2 more sources