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Additional file 1 of Non-affinity platform for processing knob-into-hole bispecific antibody

Supplementary Material 1.
Wang, Xiaoyang +5 more
openaire +1 more source

Flexible Proteins at the Origin of Life [PDF]

Almost all modern proteins possess well-defined, relatively rigid scaffolds that provide structural preorganization for desired functions. Such scaffolds require the sufficient length of a polypeptide chain and extensive evolutionary optimization.
Pohorille, Andrzej, Shannon, Gareth, Wilson, Michael A. +2 more
core +1 more source

A bispecific antibody strategy to target multiple type 2 cytokines in asthma [PDF]

, 2018
Background: Asthma is a chronic inflammatory airway disease in which innate and adaptive immune cells act together to cause eosinophilic inflammation, goblet cell metaplasia (GCM), and bronchial hyperreactivity (BHR). In clinical trials using biologicals
Blanchetot, Christophe +7 more
core +1 more source

Construction and cytotoxicity evaluation of peptide nanocarriers based on coiled-coil structures with a cyclic β-amino acid at the knob-into-hole interaction site

Journal of Materials Chemistry B
Peptides are highly attractive as nanocarriers for drug delivery and other biomedical applications due to their unique combination of biocompatibility, efficacy, safety, and versatility that are difficult to achieve with other nanocarrier types.
Monika Szefczyk +8 more
openaire +2 more sources

Bispecific antibodies: Strategies, considerations and challenges [PDF]

, 2016
Bispecific antibodies (BsAbs) are moving mainstream as therapeutics with currently two bispecific antibodies approved and about 30 in clinical development.
Spiess, Christoph
core +1 more source

New insights into the molecular mechanism of the Rab GTPase Sec4p activation [PDF]