Results 81 to 90 of about 2,562 (158)

Stabilizing and Understanding a Miniprotein by Rational Redesign [PDF]

, 2019
Miniproteins reduce the complexity of the protein-folding problem allowing systematic studies of contributions to protein folding and stabilization. Here, we describe the rational redesign of a miniprotein, PPα, comprising a polyproline II helix, a loop,
Baker, Emily, Crump, Matthew, Nicol, Debbie, Porter Goff, Kathryn, Samphire, Jennifer, Williams, Christopher, Woolfson, Derek, Zieleniewski, Francis   +7 more
core   +2 more sources

Multiple disulfide‐bonded states confer extensive conformational diversity in fibrinogen

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Disulfide bonds constrain the polypeptide backbone and reduce conformational variability in proteins. The blood clotting protein fibrinogen is constitutively produced as multiple partially disulfide‐bonded states, suggesting that individual fibrinogen molecules have a variety of conformational forms.
Aster E. Pijning, Diego Butera, Philip J. Hogg   +2 more
wiley   +1 more source

From molecular engineering to clinical applications: The expanding role of bispecific antibodies in onco-immunology

Pharmacological Research
Bispecific antibodies (bsAbs) have emerged as one of the most versatile innovations in immunotherapy, capable of simultaneously engaging two distinct epitopes within a single molecule and thereby expanding the functional repertoire of conventional ...
Richard Borrelli, Luisa Brussino, Simone Negrini, Maria Felice Brizzi   +3 more
doaj   +1 more source

Maintaining and breaking symmetry in homomeric coiled-coil assemblies [PDF]

, 2018
Higher order coiled coils with five or more helices can form α-helical barrels. Here the authors show that placing β-branched aliphatic residues along the lumen yields stable and open α-helical barrels, which is of interest for the rational design of ...
AJ Burton, AJ Mccoy, AN Lupas, AR Thomson, B North, C Chothia, C Cohen, C Gatsogiannis, C Li, CF Xu, CJ Dong, CR Calladine, CW Wood, CW Wood, DD Rodriguez, DN Woolfson, DR Roe, E Krissinel, E Moutevelis, EH Egelman, FHC Crick, G Grigoryan, GG Krivov, GM Ullmann, GN Murshudov, GR Grimsley, HR Powell, J Hume, J Liu, J Sodek, J Walshaw, J Walshaw, J Walshaw, JA Maier, JM Swails, JM Swails, K Oxenoid, KR Mahendran, L Sun, LT Bergendahl, M Wiederstein, MD Winn, NC Burgess, NL Ing, NR Zaccai, OD Testa, OJL Rackham, P Emsley, P Schuck, PB Harbury, PR Evans, PS Huang, PV Afonine, PW Rose, R Lizatovic, RK Spencer, RP Joosten, S Eshaghi, S McIntosh-Smith, S Ramisch, S. E. Ahnert, V Koronakis, VN Malashkevich, W Chen, WR Taylor   +64 more
core   +8 more sources

Taxonomic revision and conservation concerns of the trapezitine genus Croitana Waterhouse, 1932 (Lepidoptera: Hesperiidae) from Australia

Austral Entomology, Volume 65, Issue 2, May 2026.
Abstract Croitana Waterhouse, 1932 (Trapezitinae) is a small genus of skippers endemic to Australia, with most species restricted to semi‐arid and arid biomes where the larvae specialise on grasses (Poaceae) in the genera Neurachne R.Br., Enteropogon Nees and Austrostipa S.W.L. Jacobs & J.Everett.
Michael F. Braby
wiley   +1 more source

Nonhuman situational enmeshments—How participants build temporal infrastructures for ChatGPT

Journal of Linguistic Anthropology, Volume 36, Issue 1, May 2026.
Abstract This paper investigates how participants recruit Large Language Models (LLMs) like ChatGPT as interactional co‐participants depending on their temporal enmeshment within an interactional flow. Using Charles Goodwin's co‐operative action framework, we analyze video data of human–AI interaction to trace the temporal structures established by ...
Nils Klowait, Maria Erofeeva
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, Volume 600, Issue 8, Page 1222-1236, April 2026.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Field‐Effect Transistors from Artificial Charged Domain Walls in Stacked Van der Waals Ferroelectric α‐In2Se3

Advanced Materials, Volume 38, Issue 20, 7 April 2026.
This study utilizes the van der Waals stacking of ferroelectric α$\alpha$‐In2Se3 to fabricate in‐plane artificial charged domain walls. These charged domain walls are electrically accessible, gate‐tunable, and show 2–9 orders of magnitude higher conductance than charged domain walls from thin film ferroelectrics, allowing their integration in field ...
Shahriar Muhammad Nahid, Haiyue Dong, Gillian M. Nolan, SungWoo Nam, Nadya Mason, Pinshane Y. Huang, Arend M. van der Zande   +6 more
wiley   +1 more source

Design, expression, and characterization of an asymmetric bispecific antibody fused to a scFv shuttle for brain uptake [PDF]

, 2023
Please click Additional Files below to see the full ...
arlos Rivera, Juan C, Palomares, Laura A.   +1 more
core   +1 more source

The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat [PDF]

, 2004
The vasodilator-stimulated phosphoprotein (VASP) is a key regulator of actin dynamics. We have determined the 1.3-A resolution crystal structure of the 45-residue-long tetramerization domain (TD) from human VASP.
Kühnel, Karin, Jarchau, Thomas, Wolf, Eva, Schlichting, Ilme, Walter, Ulrich, Wittinghofer, Alfred, Strelkov, Sergei   +6 more
core   +3 more sources