Results 61 to 70 of about 2,562 (158)
Robust de novo designed homotetrameric coiled coils [PDF]
, 2020 De novo designed protein domains are increasingly being applied in biotechnology, cell biology and synthetic biology. Therefore, it is imperative that these proteins are robust to superficial changes, i.e., small changes to their amino-acid sequences ...
Edgell, Caitlin L +2 more
core +2 more sources
Advanced Science, EarlyView.The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob +12 more
wiley +1 more source
Structural and Functional Analysis of Cell Wall-Anchored PolypeptideAdhesin BspA in Streptococcus agalactiae [PDF]
, 2016 Streptococcus agalactiae (group B Streptococcus, GBS) is the predominant cause of early-onset infectious disease in neonates and is responsible for life-threatening infections in elderly and immunocompromised individuals.
Heal, Timothy J +9 more
core +2 more sources
Advanced Science, EarlyView.This work proposes a multifunctional Bi2WO6:Yb,Er@CuS@CS nanocomposite that integrates photodynamic therapy (PDT), near‐infrared‐triggered photothermal therapy (PTT), and Cu2+ release for infected wound repair. The nanocomposite demonstrates enhanced antibacterial efficacy via combined PDT, PTT, and Cu2+ release, effective immunomodulatory by mild ...
Yihao Sun +9 more
wiley +1 more source
Active Metamaterials with Tunable Shear Nonreciprocity and Nonlinear Dynamics
Advanced Science, EarlyView.Active gear‐based mechanical metamaterials enable simultaneous control of translational and torsional stiffnesses by 30–100×, break shear reciprocity under positive versus negative loads, broadly tune resonant frequencies, and offer programmable dynamic responses.
Xin Fang, Miao Yu, Dianlong Yu, Li Cheng
wiley +1 more source
Advanced Intelligent Systems, EarlyView.In this article, we develop bespoke resins for stereolithography 3D‐printing of soft‐robotic grippers that are controlled remotely by electrothermal stimulus near ambient temperatures. Turning on the electrical control, each finger can be actuated separately.
Kalyan Ghosh +4 more
wiley +1 more source
Continuous improvement in bispecifics manufacturing: Advantages and disadvantages of 2-cell vs. 1-cell culture process [PDF]
, 2023 Please click Additional Files below to see the full ...
Wuu, Jessica
core +1 more source
Advanced Intelligent Systems, EarlyView.We report a biodegradable electrolyte‐gated synaptic phototransistor that combines low‐power UV sensing with memory functionality, offering a sustainable platform for AI vision systems and health‐monitoring technologies. Presented here is a biodegradable, bioinspired synaptic phototransistor (SPT) based on an electrolyte‐gated field‐effect transistor ...
Theodoros Serghiou +5 more
wiley +1 more source
Drug Design, Development and Therapy, 2019 Yanxin Yin,1,2,* Jia Guo,1,2,* Fei Teng,1,2 Lihua Yu,2 Yun Jiang,2 Kun Xie,3 Ming Jiang,1,2 Jianmin Fang1–3 1Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, People’s Republic of China;
Yin Y +7 more
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Implications of molecular interactions for protein structure, function and design [PDF]
, 2005 Protein structures are kept in a delicate balance of stability by the interactions of the amino acid residues among themselves, the solvent and other molecules. On one hand they must be stable enough not to unfold, on the other hand they must be mobile
Meier, Markus
core +1 more source