Results 51 to 60 of about 2,068 (144)

Core and π‐Bridge Engineering to Deconstruct Y6‐Series into Modular Non‐Fused Acceptors: DFT‐Guided Structure‐Property Map for Organic Solar Cells

Advanced Electronic Materials, EarlyView.
The rigid fused backbone of Y6‐series acceptors is deconstructed into a modular, non‐fused A‐π‐A′‐π‐A architecture. Comprehensive quantum chemical simulations reveal that strategic core and π‐bridge engineering preserves strong near‐infrared light‐harvesting and enhances intramolecular charge‐transfer character.
Qurat ul Ain, Waqas Akram, Hasan Yaqoob, Munazza Shahid, Abdul Majid, Muhammad Altaf, Christian B. Nielsen, Raja Shahid Ashraf   +7 more
wiley   +1 more source

Controllable Superconductivity in Suspended NbSe2

Advanced Electronic Materials, EarlyView.
Suspended NbSe2${\rm NbSe}_2$ provides two complementary routes for controlling superconducting transport. Gate‐driven deformation strains the suspended crystal and tunes its critical temperature and current. Weak thermal anchoring enhances thermal feedback, contributing to multistep hysteresis and negative differential resistance.
Ruihuan Fang, Cuiju Yu, Youqiang Huang, Tosson Elalaily, Yuvraj Chaudhry, Yaoqiang Zhou, Andres Castellanos‐Gomez, Sanshui Xiao, Jiwon Park, Hyunyong Choi, Fida Ali, Hanlin Fang, Jose L. Lado, Pertti Hakonen, Zhipei Sun   +14 more
wiley   +1 more source

3D Closed‐Loop Navigation of Magnetic Microswimmers Using Vision‐Derived Depth Feedback

Advanced Intelligent Systems, EarlyView.
A planar magnetic microswimmer is navigated in three dimensions under a standard microscope. Image defocus supplies a real‐time depth cue, and model‐predictive control with A* planning steers the body on surfaces and in free swimming. Axial position is regulated by propulsion alone, without magnetic field gradients or extra cameras.
Yasin Cagatay Duygu, Sangwon Lee, Min Jun Kim   +2 more
wiley   +1 more source

Rapid Generation of Murine Bispecific Antibodies Using FAST-Ig^TM for Preclinical Screening of HER2/CD3 T-Cell Engagers

Antibodies
Bispecific antibodies (BsAbs) can bind to two different antigens, enabling therapeutic concepts that cannot be achieved with monoclonal antibodies. Immuno-competent mice are essential for validating drug discovery concepts, necessitating the development ...
Hikaru Koga, Haruka Kuroi, Rena Hirano, Hiroyuki Hirayama, Yoshiaki Nabuchi, Taichi Kuramochi   +5 more
doaj   +1 more source

Two‐Dimensional van der Waals Antiferromagnets: Fabrication, Probes, Control, and Applications

Advanced Physics Research, EarlyView.
Two‐dimensional van der Waals antiferromagnets are emerging as versatile platforms for spintronic, optoelectronic, and quantum devices. This review summarizes recent progress in their fabrication, magnetic characterization, fields, interfacial engineering, chemical modification, and representative applications.
Huangyu Wu, Zeyu Han, Yueyao Wang, Yitao Yu, Mingyang Yin, Yikang Jin, Yongjun Huo, Lihong Gao, Zhuang Ma, Gang Zhang, Miao Jiang   +10 more
wiley   +1 more source

Screening of bispecific antibodies during single cell cloning of recombinant Chinese hamster ovary cell lines to improve titer and product quality

Biotechnology Progress, EarlyView.
Abstract Development of therapeutic bispecific antibodies (BsAbs) poses significant manufacturability challenges associated with correct chain pairing and an increased diversity of impurities. Here we address this with a product quality assessment during cell line development (CLD), forgoing the need for genetic characterization during cell line ...
Molly Robinson, Jessica Willmott, Holly Corrigall, Daniela Lega, Joseph Stirling, Vithiya Vimalraj, Mitul Patel, Robyn Emmins   +7 more
wiley   +1 more source

From molecular engineering to clinical applications: The expanding role of bispecific antibodies in onco-immunology

Pharmacological Research
Bispecific antibodies (bsAbs) have emerged as one of the most versatile innovations in immunotherapy, capable of simultaneously engaging two distinct epitopes within a single molecule and thereby expanding the functional repertoire of conventional ...
Richard Borrelli, Luisa Brussino, Simone Negrini, Maria Felice Brizzi   +3 more
doaj   +1 more source

Development and application of a mechanistic model for protein A resolution of a bispecific antibody for process characterization and optimization

Biotechnology Progress, EarlyView.
Abstract Regeneron's bispecific technology, based on a fully human IgG antibody construct, consists of two distinct heavy chains and a common light chain co‐expressed in a single cell. The co‐expression of the two distinct heavy chains, one of which contains a dipeptide substitution that ablates Protein A binding, leads to the formation of three ...
Samantha Wadsworth, James Reilly, John Mattila, Christopher Cowan, Hanne Bak   +4 more
wiley   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

Rapid affinity-based purification of multi-specific antibodies using Kappa Select and Protein L

mAbs
Multispecific antibodies (msAbs) are becoming more prevalent as formats of choice for therapeutic antibody development due to their ability to modulate multiple biological targets.
Kalie Mix, Tingwan Sun, Brian Hall, Jocelyn Newton, Christina Eng, Yongjing Guo, David Reczek   +6 more
doaj   +1 more source