Results 91 to 100 of about 344,176 (312)
GABAA receptor β3 subunit mutation D120N causes Lennox–Gastaut syndrome in knock-in mice
Brain Communications, 2020 The Lennox–Gastaut syndrome is a devastating early-onset epileptic encephalopathy, associated with severe behavioural abnormalities. Its pathophysiology, however, is largely unknown. A de novo mutation (c.G358A, p.D120N) in the human GABA type-A receptor
S. Qu +6 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Ars Aequi, 2022 Wat te doen als je op Twitter door een anoniem profiel voor rotte vis wordt uitgemaakt? Het Nederlandse recht biedt verschillende mogelijkheden om identificerende gegevens te verkrijgen van internettussenpersonen. Maar hoe wordt de afweging met de bescherming van de persoonsgegevens van de anonymus gemaakt?
openaire +3 more sources
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
El complejo Bioético: pigmalión, narciso y knock
Revista Latinoamericana de Bioética, 2015 Las transformaciones de la medicina que han dado lugar a la bioética como nueva ética médica son de triple naturaleza, si bien guardan entre sí unidad de sentido.
José Alberto Mainetti
doaj +1 more source
KNOCK, KNOCK, KNOCK-IN ON GABA’S DOOR: GABRB3 Knock-in Mutation Causes Infantile Spasms in Mice
Epilepsy Currents, 2023 [Box: see text]
openaire +2 more sources
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Generalized multidimensional Hilbert transforms in Clifford analysis
International Journal of Mathematics and Mathematical Sciences, 2006 Two specific generalizations of the multidimensional Hilbert transform in Clifford analysis are constructed. It is shown that though in each of these generalizations some traditional properties of the Hilbert transform are inevitably lost, new bounded ...
Fred Brackx +2 more
doaj +1 more source