Results 71 to 80 of about 754,154 (303)

Mouse models of myeloproliferative Neoplasms: JAK of all grades. (Review) [PDF]

, 2011
In 2005, several groups identified a single gain-of-function point mutation in the JAK2 kinase that was present in the majority of patients with myeloproliferative neoplasms (MPNs).
Li, J., Kent, D.G., Chen, E., Green, A.R., Li, J., Kent, D.G., Chen, E., Green, A.R.   +7 more
core   +2 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. [PDF]

, 2016
Metastatic renal cell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associated with RCC. Von Hippel Lindau (VHL) is a tumour suppressor that is lost in the majority of clear cell RCC (ccRCC) cases.
Guan, Wei, Hermann, Kip, Hu, Junhui, Lin, Lucia C, Liu, Peijun, Mangul, Serghei, Moughon, Diana L, Pellegrini, Matteo, Schokrpur, Shiruyeh, Wu, Lily, Xu, Hua   +10 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Feynman Graphs and Generalized Eikonal Approach to High Energy Knock-Out Processes

, 1997
The cross section of hard semi-exclusive $A(e,e'N)(A-1)$ reactions for fixed missing energy and momentum is calculated within the eikonal approximation.
A. Bianconi, A. Kohama, A. Mandelstam, A. S. Rinat, B. D. Keister, B. K. Jennings, C. Ciofi degli Atti, C. D. Epp, D. R. Yennie, E. J. Moniz, F. Cannata, G. R. Farrar, J. Arvieux, L. A. Kondratyuk, L. Bertocchi, L. Frankfurt, L. L. Frankfurt, L. L. Frankfurt, L. L. Frankfurt, L. L. Frankfurt, L. L. Frankfurt, L. L. Frankfurt, L. L. Frankfurt, L. L. Frankfurt, L. L. Frankfurt, M. I. Strikman, M. M. Sargsian, N. N. Nikolaev, O. Benhar, P. Jain, R. J. Glauber, S. Frankel, S. J. Brodsky, T. H. Bauer, T.-S. H. Lee, V. N. Gribov, V. N. Gribov   +36 more
core   +1 more source

Shape and structure of N=Z 64Ge; Electromagnetic transition rates from the application of the Recoil Distance Method to knock-out reaction [PDF]

, 2007
Transition rate measurements are reported for the first and the second 2+ states in N=Z 64Ge. The experimental results are in excellent agreement with large-scale Shell Model calculations applying the recently developed GXPF1A interactions.
A. Chester, A. Dewald, A. Dunomes, A. Gade, A. M. Amthor, A. Stolz, B. A. Brown, B. Melon, C. Vaman, D. Bazin, D. Galaviz, D. Miller, D. Weisshaar, J. Jolie, K. Starosta, M. Bowen, M. Hausmann, M. Horoi, M. Portillo, O. K. Vorov, O. K. Vorov, P. Adrich, P. Miller, P. Voss, R. P. Norris, T. Baumann, T. Ginter, T. Glasmacher, T. Pissulla, V. Moeller, V. Zelevinsky, W. Rother, Y. Shimbara   +32 more
core   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Knock Knock Who's There?

Ars Aequi, 2022
Wat te doen als je op Twitter door een anoniem profiel voor rotte vis wordt uitgemaakt? Het Nederlandse recht biedt verschillende mogelijkheden om identificerende gegevens te verkrijgen van internettussenpersonen. Maar hoe wordt de afweging met de bescherming van de persoonsgegevens van de anonymus gemaakt?
openaire   +3 more sources

Two-player Knock 'em Down

, 2008
We analyze the two-player game of Knock 'em Down, asymptotically as the number of tokens to be knocked down becomes large. Optimal play requires mixed strategies with deviations of order sqrt(n) from the naive law-of-large numbers allocation.
Fill, James Allen, Wilson, David B.
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source