Results 51 to 60 of about 754,154 (303)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effect of fuel-air mixture dilution on knock intensity

Nihon Kikai Gakkai ronbunshu, 2016
Effect of fuel-air mixture diluted by inert gas on knock intensity was investigated by using a rapid compression and expansion machine. Dilution of fuel-air mixture decreased knock intensity.
Mitsuaki OHTOMO, Seiji YAMAMOTO, Hiroshi MIYAGAWA   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells. [PDF]

, 2017
In both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T helper 17 (Th17) cell migration to the central nervous system (CNS).
Atasoy, Ulus, Chen, Jing, Cramer, Carole, Drew, Paul D., Gorospe, Myriam, Martindale, Jennifer L., Yu, Shiguang   +6 more
core   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Knock-Prediction System for Kerosene Engines Using In-Cylinder Pressure Signal

Energies, 2023
Piston engines fueled by kerosene have a strong application prospect in special vehicles and small aircrafts, but the low amount of octane in kerosene fuel causes its knock combustion phenomenon to be particularly serious.
Zhixin Xu, Guangzhou Cao, Minxiang Wei, Zhuowen Zhao, Zhiyu Xing, Yuzhang Ding   +5 more
doaj   +1 more source

Microscopics of meson degrees of freedom in nucleons and mesons in nuclei - what can be seen in the process of quasielastic knockout of mesons by high-energy electrons [PDF]

, 2002
Developed earlier concept of quasielastic knock out of pions from nucleons by high-energy electrons is propounded as a tool for checking microscopical model ($^3P_0$ - fluctuation) for decay of N to different channels $\pi+B$ and Preparata model of ...
A. B. Migdal, A. Gillitzer, A. V. Andreev, B. Desplanques, D. Allasia, D. O. Riska, E. G. Drukarev, E. Weigold, G. F. Chew, H. Tyren, I. T. Obukhovsky, I. T. Obukhovsky, I. T. Obukhovsky, I. T. Obukhovsky, J. Speth, J. Speth, K. Ayat, L. L. Sviridova, M. Guidal, M. P. Rekalo, N. P. Yudin, N. P. Yudin, O. F. Nemets, P. Brauel, P. G. Roos, R. A. Adelseck, R. Alzetta, S. Nozawa, S. S. Volkov, T.-Y. Saito, V. G. Neudachin, V. G. Neudachin, V. G. Neudachin, V. G. Neudatchin, V. G. Neudatchin, V. G. Neudatchin, V. G. Neudatchin, V. G. Neudatchin, Y. B. Dong, Ya. L. Glozman, Yu. B. Ivanov, Yu. F. Smirnov, Z.-Y. Zhang   +42 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Analysis of Engine Knock Sensor

Communications, 2018
The paper deals with design of a simple device for the detection of this disorder. In the beginning of the paper the effect of the undesirable detonation combustion in internal combustion engines is described.
Daniel Korenciak, Miroslav Gutten, Juraj Adamec, Adam Glowacz, Adam Cichy   +4 more
doaj   +1 more source

“Knock for knock” en contratos de fletamento: sus elementos centrales e interpretación judicial en el derecho comparado norteamericano e inglés

Boletín Mexicano de Derecho Comparado, 2021
La noción de “knock for knock” implica un régimen contractual que aplica un principio de distribución del riesgo y asignación de sus responsabilidades asociadas. Esta distribución se realiza sobre el criterio de que cada parte soporta sus propios riesgos,
Mariano Castillo
doaj   +1 more source