Results 41 to 50 of about 344,176 (312)

Numerical Simulation of Knock Combustion in a Downsizing Turbocharged Gasoline Direct Injection Engine

Applied Sciences, 2019
Engine knock has become the prime barrier to significantly improve power density and efficiency of the engines. To further look into the essence of the abnormal combustion, this work studies the working processes of normal combustion and knock combustion
Xi Wang, Xun Zhang, Minfei Wang, Yue Han, Hanyu Chen   +4 more
doaj   +1 more source

Knock Knock, Who's There? Membership Inference on Aggregate Location Data [PDF]

Network and Distributed System Security Symposium, 2017
Aggregate location data is often used to support smart services and applications, e.g., generating live traffic maps or predicting visits to businesses.
Apostolos Pyrgelis, C. Troncoso, Emiliano De Cristofaro   +2 more
semanticscholar   +1 more source

Octane-on-Demand Concept: An Analysis Regarding Combustion Process Properties in Spark Ignition Engine

Energies
The insufficient octane ratings of commercial fuels limit the efficiency of spark-ignition (SI) engines and worsens emissions due to knock. One alternative approach to mitigate this phenomenon is the Octane-on-Demand (OOD) concept, which adjusts fuel ...
Jarosław Jaworski, Daria Jaworska-Krych, Angelina Rosiak, Hieronim Szymanowski, Krzysztof Surmiński, Grzegorz Mitukiewicz, Damian Batory   +6 more
doaj   +1 more source

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out

Human Molecular Genetics, 2020
Recent genome-wide association studies of age-at-onset in Huntington’s disease (HD) point to distinct modes of potential disease modification: altering the rate of somatic expansion of the HTT CAG repeat or altering the resulting CAG threshold length ...
Jacob M. Loupe, R. M. Pinto, Kyung-Hee Kim, T. Gillis, J. Mysore, Marissa A. Andrew, M. Kovalenko, Ryan Murtha, I. Seong, J. Gusella, S. Kwak, D. Howland, Ramee Lee, Jong-Min Lee, V. Wheeler, M. MacDonald   +15 more
semanticscholar   +1 more source

Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells

Nature Communications, 2020
The cell biology of circadian clocks is still in its infancy. Here, we describe an efficient strategy for generating knock-in reporter cell lines using CRISPR technology that is particularly useful for genes expressed transiently or at low levels, such ...
Christian H. Gabriel, M. del Olmo, A. Zehtabian, M. Jäger, S. Reischl, Hannah van Dijk, Carolin Ulbricht, A. Rakhymzhan, T. Korte, Barbara Koller, Astrid Grudziecki, B. Maier, Andreas Herrmann, R. Niesner, T. Żemojtel, H. Ewers, Adrián E. Granada, H. Herzel, A. Kramer   +18 more
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

Nature Neuroscience, 2018
Amyotrophic lateral sclerosis–frontotemporal dementia (ALS-FTD) constitutes a devastating disease spectrum characterized by 43-kDa TAR DNA-binding protein (TDP-43) pathology.
Matthew A. White, Eosu Kim, A. Duffy, R. Adalbert, Benjamin U. Phillips, O. Peters, Jodie Stephenson, Sujeong Yang, F. Massenzio, Ziqiang Lin, Simon Andrews, A. Segonds-Pichon, Jake Metterville, L. Saksida, R. Mead, R. Ribchester, Youssef Barhomi, T. Serre, M. Coleman, J. Fallon, T. Bussey, Robert H. Brown, J. Sreedharan   +22 more
semanticscholar   +1 more source

Site-Specific Gene Knock-Out and On-Site Heterologous Gene Overexpression in Chlamydomonas reinhardtii via a CRISPR-Cas9-Mediated Knock-in Method

Frontiers in Plant Science, 2020
Chlamydomonas reinhardtii is being transformed from a model organism to an industrial organism for the production of pigments, fatty acids, and pharmaceuticals. Genetic modification has been used to increase the economic value of C. reinhardtii. However,
Jongrae Kim, Sangmuk Lee, Kwangryul Baek, E. Jin   +3 more
semanticscholar   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source