Results 41 to 50 of about 754,154 (303)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Prediction of lethal and synthetically lethal knock-outs in regulatory networks

, 2013
The complex interactions involved in regulation of a cell's function are captured by its interaction graph. More often than not, detailed knowledge about enhancing or suppressive regulatory influences and cooperative effects is lacking and merely the ...
A Inger, A Szejka, A Wagner, B Derrida, DA Chan, F Li, Florian Greil, G Boldhaus, G Boldhaus, Gunnar Boldhaus, H Jeong, I Ispolatov, J Visser de, JL Hartman, JX Luo, Konstantin Klemm, LC Freeman, M Aldana, M Davidich, NE Buchler, R Albert, R Pastor-Satorras, RV Solé, S Bornholdt, S Wuchty, SA Kauffman, T Fawcett, U Alon, U Brandes   +28 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Performance analysis of knock detectors [PDF]

, 2006
This paper examines performance of the knock detection technique typically used in engine control systems, and the margin for possible improvement. We introduce a knock signal model and obtain an analytical result for the associated receiver operating ...
Galtier, Frédéric, Vincent, François, Vingerhoeds, Rob A., Zadnik, Martin   +3 more
core  

Conditional sampling for barrier option pricing under the LT method [PDF]

, 2011
We develop a conditional sampling scheme for pricing knock-out barrier options under the Linear Transformations (LT) algorithm from Imai and Tan (2006).
Derman E., Derman E., Giles M. B., Imai J., Nuyens D., Traub J., Zvan R.   +6 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Numerical Analysis of End-Gas Autoignition and Pressure Oscillation in a Downsized SI Engine Using Large Eddy Simulation

Energies, 2019
Knock and super-knock are abnormal combustion phenomena in engines, however, they are hard to study comprehensively through optical experimental methods due to their inherent destructive nature.
Lijia Zhong, Changwen Liu
doaj   +1 more source

Proximal design in South African informal settlements: users as designers and the construction of the built environment and its fire risks

Tapuya, 2020
Informal settlements present a challenge for fire safety because they lack the regulation of building standards that have been central to reducing fire risks elsewhere.
Graham Spinardi, S.J. Cooper-Knock, David Rush   +2 more
doaj   +1 more source

Study on joint detection of fabricated concrete shear wall based on percussion method [PDF]

MATEC Web of Conferences, 2019
The knock detection method is one of the non-destructive testing methods for assembly prefabricated components. The knocker is used to knock on the concrete prefabricated components to be tested.
Song Bo, Li Jian, Wang Man sheng
doaj   +1 more source

Efficient DNA knock-in using AAV-mediated delivery with 2-cell embryo CRISPR-Cas9 electroporation

Frontiers in Genome Editing, 2023
Recent advances in CRISPR-Cas genome editing technology have been instrumental in improving the efficiency to produce genetically modified animal models.
Daniel J. Davis, James F. McNew, Hailey Maresca-Fichter, Kaiwen Chen, Bhanu P. Telugu, Elizabeth C. Bryda, Elizabeth C. Bryda   +6 more
doaj   +1 more source