Results 81 to 90 of about 344,176 (312)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

A Pressure-Oscillation-Based RON Estimation Method for Spark Ignition Fuels beyond RON 100

Energies
Knock in spark ignition (SI) engines occurs when the air–fuel mixture in the combustion chamber ignites spontaneously ahead of the flame front, reducing combustion efficiency and possibly leading to engine damage if left unattended.
Tom Robeyn, Victor Sileghem, Tara Larsson, Sebastian Verhelst   +3 more
doaj   +1 more source

Knock Detection in Spark Ignition Engines Base on Complementary Ensemble Empirical Mode Decomposition-Hilbert Transform

Shock and Vibration, 2016
In spark ignition engines, knock onset limits the maximum spark advance. An inaccurate identification of this limit penalises the fuel conversion efficiency.
Fengrong Bi, Teng Ma, Jian Zhang, Lin Li, Chunfang Shi   +4 more
doaj   +1 more source

Analysis of SUMO1-conjugation at synapses

eLife, 2017
SUMO1-conjugation of proteins at neuronal synapses is considered to be a major post-translational regulatory process in nerve cell and synapse function, but the published evidence for SUMO1-conjugation at synapses is contradictory.
James A Daniel, Benjamin H Cooper, Jorma J Palvimo, Fu-Ping Zhang, Nils Brose, Marilyn Tirard   +5 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

A statistical analysis of developing knock intensity in a mixture with temperature inhomogeneities

, 2020
Knock formation and its intensity for a stoichiometric ethanol/air mixture under a representative end-gas auto-ignition condition in IC engines with temperature inhomogeneities are investigated using multi-dimensional direct numerical simulations (DNS ...
M. Luong, Swapnil Desai, F. H. Hernández Pérez, R. Sankaran, B. Johansson, H. Im   +5 more
semanticscholar   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

CRISPR/Cas9-induced knockout and knock-in mutations in Chlamydomonas reinhardtii

Scientific Reports, 2016
Genome editing is crucial for genetic engineering of organisms for improved traits, particularly in microalgae due to the urgent necessity for the next generation biofuel production.
Sung-Eun Shin, J. Lim, H. Koh, Eun Kyung Kim, N. Kang, Seungjib Jeon, Sohee Kwon, Won-Sub Shin, Bongsoo Lee, Kwon Hwangbo, Jungeun Kim, Sunghyeok Ye, Jae-Young Yun, Hogyun Seo, H. Oh, Kyung-Jin Kim, Jin-Soo Kim, Won-Joong Jeong, Y. Chang, Byeong-ryool Jeong   +19 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Lentivirus-mediated interleukin-1β (IL-1β) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice

Journal of Neuroinflammation, 2017
Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction in rodents.
Mengmeng Li, Chenli Li, Hanjie Yu, Xiongxiong Cai, Xinbei Shen, Xin Sun, Jinting Wang, Yanhua Zhang, Chuang Wang   +8 more
semanticscholar   +1 more source