Results 121 to 130 of about 218,644 (293)

Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance

Cancer Science, 2009
Chemotherapy resistance in solid tumors is broad and encompasses diverse unrelated drugs. Three‐dimensional multicellular spheroids (MCSs) are a good model for studying in vitro drug resistance. In the current study, we investigated the role of focal adhesion kinase (FAK) in 5‐fluorouracil (5‐FU) chemoresistance in colon carcinoma MCS culture cells ...
Yu-Ying, Chen, Zhan-Xiang, Wang, Ping-An, Chang, Jian-Jun, Li, Feng, Pan, Li, Yang, Zhi-Heng, Bian, Lan, Zou, Jian-Ming, He, Hou-Jie, Liang   +9 more
openaire   +2 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Knockdown of nucleophosmin by RNA interference reverses multidrug resistance in resistant leukemic HL-60 cells

Immunobiology, 2013
Nucleophosmin, a multifunctional nucleolar phosphoprotein, is involved in many cellular activities. However, the role of NPM in drug-resistance of leukemia has not yet been explored. We designed and selected one shRNA targeting on NPM gene transduction into HL-60 and HL-60/ADR cell lines (an adriamycin resistant cell line) by lentivirus.
Minhui, Lin, Jianda, Hu, Tingbo, Liu, Jing, Li, Buyuan, Chen, Xinji, Chen   +5 more
openaire   +2 more sources

Hypoxia-Induced Upregulation of HE4 Is Responsible for Resistance to Radiation Therapy of Gastric Cancer

Molecular Therapy: Oncolytics, 2019
Upregulation of human epididymis protein 4 (HE4) is often observed in different types of cancers, including gastric cancer (GC), but the association of elevated HE4 level with radiation resistance in GC remains unclear.
Chunwei Peng, Guangjie Liu, Kai Huang, Qiang Zheng, Yunsong Li, Changjun Yu   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anopheles gambiae s.s.

, 1998
Pyrethroid-impregnated bednets are playing an increasing role for combating malaria, especially in stable malaria areas. More than 90% of the current annual malaria incidence (c.
Pasteur, Nicole, Williamson, M.S., Guillet, Pierre, Devonshire, Alan L., Darriet, F., Darriet, Frédéric, Martinez-Torres, David, Pasteur, N., Devonshire, A. L., Pauron, David, Berge, Jean B., Devonshire, A.L., Martinez-Torres, D., Pauron, D., Berge, J. B., Chandre, F., Guillet, P., Bergé, J.B., Chandre, Fabrice, Williamson, M. S.   +19 more
core   +1 more source

Molecular Ecology of Pyrethroid Knockdown Resistance in Culex pipiens pallens Mosquitoes

PLoS ONE, 2010
Pyrethroid insecticides have been extensively used in China and worldwide for public health pest control. Accurate resistance monitoring is essential to guide the rational use of insecticides and resistance management. Here we examined the nucleotide diversity of the para-sodium channel gene, which confers knockdown resistance (kdr) in Culex pipiens ...
Chen, Lin, Zhong, Daibin, Zhang, Donghui, Shi, Linna, Zhou, Guofa, Gong, Maoqing, Zhou, Huayun, Sun, Yan, Ma, Lei, He, Ji, Hong, Shanchao, Zhou, Dan, Xiong, Chunrong, Chen, Chen, Zou, Ping, Zhu, Changliang, Yan, Guiyun   +16 more
openaire   +4 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling

, 2008
Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes.
Field, L.M., Andrias O O'Reilly, Williamson, M.S., Wallace, Bonnie A., BA Wallace, Linda M Field, TG Emyr Davies, Wallace, B. A., Davies, T.G.E., O’Reilly, Andrias O., Field, L. M., O'Reilly, A. O., Davies, T. G. E., Martin S Williamson, Williamson, M. S.   +14 more
core   +1 more source