Results 111 to 120 of about 218,644 (293)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Combining indoor residual spraying with chlorfenapyr and long-lasting insecticidal bed nets for improved control of pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Benin. [PDF]

, 2011
BACKGROUND: Neither indoor residual spraying (IRS) nor long-lasting insecticidal nets (LLINs) are able to fully interrupt transmission in holoendemic Africa as single interventions.
Mark Rowland, N'Guessan Raphael, Estelle Vigninou, Boko, Pelagie, Asidi, A, Akogbeto Martin, Abibatou Odjo, Boko Pelagie, Alex Asidi, Akogbeto, Martin, Rowland, M, Rowland Mark, N'Guessan, Raphael, Vigninou, E, Vigninou Estelle, Vigninou, Estelle, Rowland, Mark, Akogbeto, M, Ngufor Corine, Odjo Abibatou, N'guessan, R, Ngufor, C, Odjo, A, Martin Akogbeto, Odjo, Abibatou, Pelagie Boko, Asidi, Alex, Ngufor, Corine, Raphael N'Guessan, Boko, P, Corine Ngufor, Asidi Alex   +31 more
core   +1 more source

Knockdown of BAP31 Overcomes Hepatocellular Carcinoma Doxorubicin Resistance through Downregulation of Survivin

, 2023
The expression of B-cell receptor associated protein 31 (BAP31) is increased in many tumor types, and it is reported to participate in proliferation, migration, and apoptosis. However, the relationship between BAP31 and chemoresistance is uncertain. This
Jingjing Liu, Changli Wang, Tianyi Wang, Sheng Yang, Qi Zhang, Jiaying Yang, Bing Wang   +6 more
core   +1 more source

Trends and patterns of insecticide susceptibility of Anopheles gambiae between 2015 and 2020: implications for malaria vector control interventions in Ghana

Malaria Journal
Background The distribution and use of insecticide treated nets (ITNs) and indoor residual spraying (IRS) are the two main insecticide-based tools that have been scaled up in Ghana.
Andy Asafu-Adjaye, Joseph Chabi, Keziah Malm, Otubea Owusu Akrofi, Sylvester Coleman, Dominic B. Dery, Yemane Yihdego, Kwadwo Kyereme Frempong, Sellase Pi-Bansa, Michelle Ayuritolya Asigbaase, Rebecca Pwalia, Joannitta Joannides, Kojo Yirenkyi Sakyi, Osei Kwaku Akuoko, Joseph Harold Nyarko Osei, Duncan K. Athinya, Aba Baffoe-Wilmot, Constance Bart-Plange, Daniel Adjei Boakye, Samuel Kweku Dadzie   +19 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Susceptibility of adult cat fleas (Siphonaptera: Pulicidae) to insecticides and status of insecticide resistance mutations at the rdl and knockdown resistance loci [PDF]

, 2015
The susceptibility of 12 field-collected isolates and 4 laboratory strains of cat fleas, Ctenocephalides felis was determined by topical application of some of the insecticides used as on-animal therapies to control them.
Mencke, N., Tetzner, Kathrin, Bohm, Claudia, Norbert Mencke, Foit, S., Foit, Sabrina, Hostetler, J, Richard Vetter, Ian Denholm, Martin S. Williamson, Glen Coleman, Joe Hostetler, Kopp, S., Hostetler, J., Rust, MK, Vetter, Richard, Bohm, C., Rees, R, Tetzner, K, Mencke, Norbert, Denholm, Ian, Blagburn, B, Boehm, C, Vetter, R., Williamson, M, Davis, W., Wendell Davis, Williamson, Martin S., Vetter, R, Steven Kopp, Blagburn, B., Davis, W, Byron Blagburn, Foit, S, Kathrin Tetzner, Hostetler, Joe, Rees, Robert, Sabrina Foit, Rust, M. K., Rust, Michael K., Williamson, M. S., Denholm, I., Kopp, Steven, Blagburn, Byron, Michael K. Rust, Coleman, G., Rees, R., Tetzner, K., Davis, Wendell, Coleman, Glen, Claudia Böhm, Robert Rees   +51 more
core   +1 more source

Genetic profile and molecular resistance of Aedes (Stegomyia) aegypti (Diptera: Culicidae) in Foz do Iguaçu (Brazil), at the border with Argentina and Paraguay

Zoologia (Curitiba), 2012
The genetic variability of populations of Aedes (Stegomyia) aegypti (Linnaeus, 1762) is often low due to the intense selection pressure caused by chemical control measures.
Ana C. Dalla Bona, Carla F. Piccoli, André de S. Leandro, Rosinei Kafka, Adriana L. Twerdochilib, Mário A. Navarro-Silva   +5 more
doaj  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Combining unrelated insecticides for improved control and management of insecticide resistant African malaria vectors [PDF]

It is now generally accepted that if nothing is done and insecticide resistance in malaria vectors especially to pyrethroids eventually led to widespread failure of current vector control strategies, the progress achieved so far in reducing the burden of
Ngufor, CA
core   +1 more source

Combining organophosphate treated wall linings and long-lasting insecticidal nets for improved control of pyrethroid resistant Anopheles gambiae. [PDF]

, 2014
BACKGROUND: New approaches to delivering insecticides need to be developed to improve malaria vector control. Insecticidal durable wall lining (DL) and net wall hangings (NWH) are novel alternatives to indoor residual spraying which can be produced in a ...
Mark Rowland, Dabire Roch, Tchicaya, Emile, Johnson, Paul, Roch Dabire, Rowland Mark, Ranson, Hilary, N'Fale, S., Dabire, R., Ngufor, C., Koudou, B., Koudou, Benjamin, Rowland, Mark, Johnson, P., Ranson, H., Ngufor Corine, Tchicaya, E., Ranson, Hilary; id_orcid, Benjamin Koudou, Sagnon N'Fale, Paul Johnson, Mark Rowl, Koudou Benjamin, Dabire, Roch, N'Fale, Sagnon, Tchicaya Emile, Rowland, M., Ngufor, Corine, Emile Tchicaya, N'Fale Sagnon, Johnson Paul, Corine Ngufor, Hilary Ranson, Ranson Hilary   +33 more
core   +1 more source