Results 111 to 120 of about 2,501,241 (289)

The cytochrome P450 CYP6P4 is responsible for the high pyrethroid resistance in knockdown resistance-free Anopheles arabiensis

Insect Biochemistry and Molecular Biology, 2016
Pyrethroid insecticides are the front line vector control tools used in bed nets to reduce malaria transmission and its burden. However, resistance in major vectors such as Anopheles arabiensis is posing a serious challenge to the success of malaria control.
Ibrahim, SS, Riveron, JM, Stott, R, Irving, H, Wondji, CS   +4 more
openaire   +3 more sources

TSG6 affects anti cancer drug resistance and angiogenesis in 3D spheroid model of canine mammary gland tumor cells

Scientific Reports
TSG6 (Tumor necrosis factor stimulated gene-6) plays a critical role in modulating the tumor microenvironment by regulating inflammation, immune responses, and extracellular matrix remodeling.
Ga-Hyun Lim, Ju-Hyun An, Jeong-Hwa Lee, Kyoung-Won Seo, Hwa-Young Youn   +4 more
doaj   +1 more source

Tumor cell-intrinsic NSUN2 deficiency reprograms macrophages to sensitize non-small cell lung cancer to EGFR inhibitors by reversing immune evasion

Neoplasia: An International Journal for Oncology Research
Despite EGFR-tyrosine kinase inhibitors (EGFR-TKI) have improved outcomes in non-small cell lung cancer (NSCLC), acquired resistance remains a challenge.
Yueqin Wang, Jingyao Wei, Wenbin Xu, Yu Zhang, Luyao Feng, Lizhen Zhang, Shuaibing Liu, Xin Tian   +7 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Molecular Ecology of Pyrethroid Knockdown Resistance in Culex pipiens pallens Mosquitoes

PLoS ONE, 2010
Pyrethroid insecticides have been extensively used in China and worldwide for public health pest control. Accurate resistance monitoring is essential to guide the rational use of insecticides and resistance management. Here we examined the nucleotide diversity of the para-sodium channel gene, which confers knockdown resistance (kdr) in Culex pipiens ...
Chen, Lin, Zhong, Daibin, Zhang, Donghui, Shi, Linna, Zhou, Guofa, Gong, Maoqing, Zhou, Huayun, Sun, Yan, Ma, Lei, He, Ji, Hong, Shanchao, Zhou, Dan, Xiong, Chunrong, Chen, Chen, Zou, Ping, Zhu, Changliang, Yan, Guiyun   +16 more
openaire   +4 more sources

Trends and patterns of insecticide susceptibility of Anopheles gambiae between 2015 and 2020: implications for malaria vector control interventions in Ghana

Malaria Journal
Background The distribution and use of insecticide treated nets (ITNs) and indoor residual spraying (IRS) are the two main insecticide-based tools that have been scaled up in Ghana.
Andy Asafu-Adjaye, Joseph Chabi, Keziah Malm, Otubea Owusu Akrofi, Sylvester Coleman, Dominic B. Dery, Yemane Yihdego, Kwadwo Kyereme Frempong, Sellase Pi-Bansa, Michelle Ayuritolya Asigbaase, Rebecca Pwalia, Joannitta Joannides, Kojo Yirenkyi Sakyi, Osei Kwaku Akuoko, Joseph Harold Nyarko Osei, Duncan K. Athinya, Aba Baffoe-Wilmot, Constance Bart-Plange, Daniel Adjei Boakye, Samuel Kweku Dadzie   +19 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Genetic profile and molecular resistance of Aedes (Stegomyia) aegypti (Diptera: Culicidae) in Foz do Iguaçu (Brazil), at the border with Argentina and Paraguay

Zoologia (Curitiba), 2012
The genetic variability of populations of Aedes (Stegomyia) aegypti (Linnaeus, 1762) is often low due to the intense selection pressure caused by chemical control measures.
Ana C. Dalla Bona, Carla F. Piccoli, André de S. Leandro, Rosinei Kafka, Adriana L. Twerdochilib, Mário A. Navarro-Silva   +5 more
doaj  

Combining unrelated insecticides for improved control and management of insecticide resistant African malaria vectors [PDF]

It is now generally accepted that if nothing is done and insecticide resistance in malaria vectors especially to pyrethroids eventually led to widespread failure of current vector control strategies, the progress achieved so far in reducing the burden of
Ngufor, CA
core   +1 more source