Results 101 to 110 of about 2,501,241 (289)

Evaluation of Knockdown Bioassay Methods to Assess Phosphine Resistance in the Red Flour Beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae)

Insects, 2019
Resistance to the fumigant phosphine in Tribolium castaneum occurs worldwide. This study evaluated tests based on adult knockdown time, the time for a beetle to become immobile, when exposed to a high concentration of phosphine.
Aaron Cato, Edwin Afful, Manoj K. Nayak, Thomas W. Phillips   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Pyrethroids resistance and distribution of kdr mutations (L1014F and N1575Y) in Anopheles gambiae s.l. along the south-north transect of Benin

Malaria Journal
Background Pyrethroid resistance in Anopheles gambiae s.l. compromises malaria vector control in sub-Saharan Africa. In Benin, resistance has been documented for over two decades, but the geographic distribution of emerging mutations such as N1575Y ...
Razaki A. Ossé, Steve Zinsou Hougbe, Minassou Juvenal Ahouandjinou, Aboubacar Sidick, Zul-kifl Affolabi, Koffi Djigbodi Koumodji, Filémon Tokponnon, Rock Aikpon, Arthur Sovi, Haziz A. Sina Orou, Lamine Baba-Moussa, Martin Akogbeto   +11 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

An experimental hut evaluation of PermaNet(®) 3.0, a deltamethrin-piperonyl butoxide combination net, against pyrethroid-resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes in southern Benin.

, 2010
PermaNet 3.0 is a long-lasting combination net with deltamethrin present on the sides and a mixture of deltamethrin and piperonyl butoxide (PBO), an oxidase synergist, on the top panel.
Mark Rowland, Rowland, Mark, Boko, Pelagie, Pigeon, Olivier, Abibatou Odjo, Olivier Pigeon, Alex Asidi, Martin Akogbeto, Odjo, Abibatou, Akogbeto, Martin, Pelagie Boko, Asidi, Alex, N'Guessan, Raphael, Raphael N’Guessan   +13 more
core   +1 more source

Combining indoor residual spraying with chlorfenapyr and long-lasting insecticidal bed nets for improved control of pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Benin. [PDF]

, 2011
BACKGROUND: Neither indoor residual spraying (IRS) nor long-lasting insecticidal nets (LLINs) are able to fully interrupt transmission in holoendemic Africa as single interventions.
Mark Rowland, N'Guessan Raphael, Estelle Vigninou, Boko, Pelagie, Asidi, A, Akogbeto Martin, Abibatou Odjo, Boko Pelagie, Alex Asidi, Akogbeto, Martin, Rowland, M, Rowland Mark, N'Guessan, Raphael, Vigninou, E, Vigninou Estelle, Vigninou, Estelle, Rowland, Mark, Akogbeto, M, Ngufor Corine, Odjo Abibatou, N'guessan, R, Ngufor, C, Odjo, A, Martin Akogbeto, Odjo, Abibatou, Pelagie Boko, Asidi, Alex, Ngufor, Corine, Raphael N'Guessan, Boko, P, Corine Ngufor, Asidi Alex   +31 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Pyrethroid resistance status and co-occurrence of V1016G, F1534C and S989P mutations in the Aedes aegypti population from two dengue outbreak counties along the China-Myanmar border

Parasites & Vectors
Background Over the past two decades, dengue fever (DF) has emerged as a significant arboviral disease in Yunnan province, China, particularly in the China-Myanmar border area.
Li Chen, Kemei Zhou, Jun Shi, Yuting Zheng, Xiaotao Zhao, Qingyun Du, Yingkun Lin, Xaioxiong Yin, Jinyong Jiang, Xinyu Feng   +9 more
doaj   +1 more source

Induction of paclitaxel resistance by ERα mediated prohibitin mitochondrial-nuclear shuttling.

PLoS ONE, 2013
Paclitaxel is a drug within one of the most promising classes of anticancer agents. Unfortunately, clinical success of this drug has been limited by the insurgence of cellular resistance.
Pei Dong, Lijuan Jiang, Jianye Liu, Zhiming Wu, Shengjie Guo, Ziling Zhang, Fangjian Zhou, Zhuowei Liu   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source