Results 91 to 100 of about 2,501,241 (289)

The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy

Journal of Hematology & Oncology, 2019
Background Tamoxifen resistance remains a clinical challenge for hormone receptor-positive breast cancer. Recently, dysregulations in autophagy have been suggested as a potential mechanism for tamoxifen resistance.
Ji Wang, Shuduo Xie, Jingjing Yang, Hanchu Xiong, Yunlu Jia, Yulu Zhou, Yongxia Chen, Xiaogang Ying, Cong Chen, Chenyang Ye, Linbo Wang, Jichun Zhou   +11 more
doaj   +1 more source

LncRNA HOTAIR induces sunitinib resistance in renal cancer by acting as a competing endogenous RNA to regulate autophagy of renal cells

Cancer Cell International, 2020
Background Cell autophagy has been proposed to be involved in drug resistance therapy. However, how the long non-coding RNA (lncRNA) reduces risks of drug resistance in renal cancer (RC) cells needs a thorough inquiry.
Dechao Li, Changfu Li, Yongsheng Chen, Lichen Teng, Yan Cao, Wentao Wang, Hongxin Pan, Yongpeng Xu, Dan Yang   +8 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Synergy in efficacy of fungal entomopathogens and permethrin against West African insecticide-resistant Anopheles gambiae mosquitoes. [PDF]

, 2010
BACKGROUND: Increasing incidences of insecticide resistance in malaria vectors are threatening the sustainable use of contemporary chemical vector control measures.
Knols, B.G.J., Mark Rowland, Annabel F V Howard, Farenhorst, Marit, Knols, Bart G. J., N’Guessan Raphael, N'Guessan, R., Howard, A.F.V., Thomas, Matthew B., Annabel F. V. Howard, Rowland Mark, Knols, Bart GJ, Farenhorst, M., N'Guessan, Raphael, Takken, W., Thomas Matthew B., Raphael N’Guessan, Farenhorst Marit, Howard Annabel F. V., Rowland, Mark, Howard, Annabel F. V., Matthew B. Thomas, Thomas, Matthew B, Howard, Annabel FV, Takken, Willem, Takken Willem, Knols Bart G. J., Thomas, M.B., Matthew B Thomas, Rowland, M., Raphael N'Guessan, Marit Farenhorst, Bart G. J. Knols, Bart G J Knols, Willem Takken   +34 more
core   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Pyrethroid resistance in tropical bedbugs, Cimex hemipterus, associated with use of treated bednets.

, 2002
When Tanzanian villages were provided with pyrethroid-treated bednets, bedbugs (Cimicidae) disappeared; however, after about 6 years they have re-appeared in these villages. Using a newly devised test-kit, susceptibility tests of bedbugs Cimex hemipterus
Maxwell, CA, J. Myamba, C. F. Curtis, Asidi, A, A. Asidi, C. A. Maxwell, Curtis, CF, Myamba, J   +7 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus populations of the Mekong region [PDF]

Parasites & Vectors, 2010
Abstract Background In the Mekong region (Vietnam, Cambodia and Laos), a large investigation was conducted to assess the susceptibility of Anopheles species against DDT and pyrethroids. In this study, the resistance status of the potential malaria vectors An. vagus, An. sinensis, An. paraliae and An. peditaeniatus was
Verhaeghen, Katrijn, van Bortel, Wim, Ho, Dinh Trung, Sochantha, Tho, Keokenchanh, Kalouna, Coosemans, Marc   +5 more
openaire   +4 more sources

A Point Mutation V419L in the Sodium Channel Gene from Natural Populations of Aedes aegypti Is Involved in Resistance to λ-Cyhalothrin in Colombia

Insects, 2018
Resistance to pyrethroids in mosquitoes is mainly caused by target site insensitivity known as knockdown resistance (kdr). In this work, we examined the point mutations present in portions of domains I, II, III, and IV of the sodium channel gene in Aedes
Yurany Granada, Ana María Mejía-Jaramillo, Clare Strode, Omar Triana-Chavez   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source