Results 91 to 100 of about 218,644 (293)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Synergy in efficacy of fungal entomopathogens and permethrin against West African insecticide-resistant Anopheles gambiae mosquitoes. [PDF]

, 2010
BACKGROUND: Increasing incidences of insecticide resistance in malaria vectors are threatening the sustainable use of contemporary chemical vector control measures.
Knols, B.G.J., Mark Rowland, Annabel F V Howard, Farenhorst, Marit, Knols, Bart G. J., N’Guessan Raphael, N'Guessan, R., Howard, A.F.V., Thomas, Matthew B., Annabel F. V. Howard, Rowland Mark, Knols, Bart GJ, Farenhorst, M., N'Guessan, Raphael, Takken, W., Thomas Matthew B., Raphael N’Guessan, Farenhorst Marit, Howard Annabel F. V., Rowland, Mark, Howard, Annabel F. V., Matthew B. Thomas, Thomas, Matthew B, Howard, Annabel FV, Takken, Willem, Takken Willem, Knols Bart G. J., Thomas, M.B., Matthew B Thomas, Rowland, M., Raphael N'Guessan, Marit Farenhorst, Bart G. J. Knols, Bart G J Knols, Willem Takken   +34 more
core   +1 more source

Bacterial-Mediated Knockdown of Tumor Resistance to an Oncolytic Virus Enhances Therapy [PDF]

Molecular Therapy, 2014
Oncolytic viruses (OVs) and bacteria share the property of tumor-selective replication following systemic administration. In the case of nonpathogenic bacteria, tumor selectivity relates to their ability to grow extracellularly within tumor stroma and is therefore ideally suited to restricting the production of bacterially produced therapeutic agents ...
Cronin, Michelle, Le Boeuf, Fabrice, Murphy, Carola, Roy, Dominic G, Falls, Theresa, Bell, John C, Tangney, Mark   +6 more
openaire   +2 more sources

Knockdown of circ_NEK6 Decreased I Resistance of Differentiated Thyroid Carcinoma via Regulating miR-370-3p/MYH9 Axis

Technology in Cancer Research & Treatment, 2021
Radioresistance is a crucial factor for the failure of iodine 131 ( 131 I)-based radiotherapy for differentiated thyroid carcinoma (DTC). This study aimed to explore the effect of circ_NEK6 on the development of 131 I resistance in DTC and its potential ...
Fukun Chen, Shuting Yin, Zhiping Feng, Chao Liu, Juan Lv, Yuanjiao Chen, Ruoxia Shen, Jiaping Wang, Zhiyong Deng   +8 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A Point Mutation V419L in the Sodium Channel Gene from Natural Populations of Aedes aegypti Is Involved in Resistance to λ-Cyhalothrin in Colombia

Insects, 2018
Resistance to pyrethroids in mosquitoes is mainly caused by target site insensitivity known as knockdown resistance (kdr). In this work, we examined the point mutations present in portions of domains I, II, III, and IV of the sodium channel gene in Aedes
Yurany Granada, Ana María Mejía-Jaramillo, Clare Strode, Omar Triana-Chavez   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

An experimental hut evaluation of PermaNet(®) 3.0, a deltamethrin-piperonyl butoxide combination net, against pyrethroid-resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes in southern Benin.

, 2010
PermaNet 3.0 is a long-lasting combination net with deltamethrin present on the sides and a mixture of deltamethrin and piperonyl butoxide (PBO), an oxidase synergist, on the top panel.
Mark Rowland, Rowland, Mark, Boko, Pelagie, Pigeon, Olivier, Abibatou Odjo, Olivier Pigeon, Alex Asidi, Martin Akogbeto, Odjo, Abibatou, Akogbeto, Martin, Pelagie Boko, Asidi, Alex, N'Guessan, Raphael, Raphael N’Guessan   +13 more
core   +1 more source

Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus populations of the Mekong region [PDF]

Parasites & Vectors, 2010
Abstract Background In the Mekong region (Vietnam, Cambodia and Laos), a large investigation was conducted to assess the susceptibility of Anopheles species against DDT and pyrethroids. In this study, the resistance status of the potential malaria vectors An. vagus, An. sinensis, An. paraliae and An. peditaeniatus was
Verhaeghen, Katrijn, van Bortel, Wim, Ho, Dinh Trung, Sochantha, Tho, Keokenchanh, Kalouna, Coosemans, Marc   +5 more
openaire   +4 more sources