Results 261 to 270 of about 218,644 (293)

Toxicological and molecular characterisation of pyrethroid knockdown resistance (KDR ) in the peach-potato aphid, Myzus persicae Sulzer

, 2001
Foster, S. P., Denholm, I., Eleftherianos, I., Goodson, S. J., Williamson, M. S.   +4 more
core  

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

Characterisation of knockdown resistance to pyrethroid insecticides in the peach-potato aphid, Myzus persicae

, 2002
Denholm, I., Foster, S. P., Eleftherianos, I., Anstead, J., Williamson, M. S.   +4 more
core  

Pyrethroids, knockdown resistance and sodium channels [PDF]

Pest Management Science, 2008
AbstractKnockdown resistance to DDT and the pyrethrins was first described in 1951 in the housefly (Musca domestica L.). This trait, which confers reduced neuronal sensitivity to these insecticides, was subsequently shown to confer cross‐resistance to all synthetic pyrethroid insecticides that have been examined to date. As a consequence, the worldwide
David M Söderlund
exaly   +3 more sources

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The molecular biology of knockdown resistance to pyrethroid insecticides

Insect Biochemistry and Molecular Biology, 2003
The term "knockdown resistance" is used to describe cases of resistance to diphenylethane (e.g. DDT) and pyrethroid insecticides in insects and other arthropods that result from reduced sensitivity of the nervous system. Knockdown resistance, first identified and characterized in the house fly (Musca domestica) in the 1950's, remains a threat to the ...
D M Söderlund
exaly   +3 more sources

Detection of L1014F knockdown resistance mutation in Culex tritaeniorhynchus populations

Pesticide Biochemistry and Physiology, 2022
Culex tritaeniorhynchus is a major Japanese encephalitis virus vector distributed in Southeast Asia and surrounding countries. The aim of the present study is to investigate insecticide resistance status among 10 Cx. tritaeniorhynchus populations of the Mediterranean region of Turkey.
Sare İlknur, Yavaşoğlu, Fatma, Bursalı, Fatih Mehmet, Şimşek   +2 more
openaire   +2 more sources

Molecular studies of knockdown resistance to pyrethroids: cloning of domain II sodium channel gene sequences from insects

, 1997
Knockdown resistance (kdr) is a target-site resistance mechanism that confers nerve insensitivity to DDT and pyrethroid insecticides. In the housefly, Musca domestica, molecular cloning of the para-type sodium channel gene has revealed two amino acid ...
David Martínez-Torres, Alan L Devonshire, Martin S Williamson   +2 more
exaly   +2 more sources

C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy

Biochemical and Biophysical Research Communications, 2022
Insulin resistance (IR) attributed by the deficiency of lipophagy, is an abnormal state of downregulation of insulin-mediated glucose uptake and use into the liver. Chromosome 9 open reading frame 72 (C9orf72) variously modulates autophagy. We investigated the role and the downstream pathway of C9orf72 in hepatic IR.
Xiaomin, Cang, Yu, Wang, Jia, Zeng, Jingwen, Gao, Qianqian, Yu, Chunfeng, Lu, Feng, Xu, Jiaxi, Lin, Jinzhou, Zhu, Xueqin, Wang   +9 more
openaire   +2 more sources

TOP2A Knockdown Resensitizes Carfilzomib-Resistant Hmcls to Carfilzomib

Blood, 2015
Abstract Introduction/background: Multiple myeloma (MM) remains incurable despite the introduction of novel therapeutic agents. Microarray-based technologies were adopted in our study to determine if a genetic signature associated with resistance to carfilzomib, a second-generation proteasome inhibitor already in use in clinical settings,
A. Reale, T. Khong, S. Mithraprabhu, M. Ramachandran, I. Savvidou, A. Spencer   +5 more
openaire   +1 more source

The Knockdown Resistance (kdr) Mutation in Pyrethroid-Resistant German Cockroaches

Pesticide Biochemistry and Physiology, 1998
Abstract A point mutation in thepara-homologous sodium channel gene has been shown to be associated with knockdown resistance (kdr) in several insect species including the German cockroach. In this study, we analyzed the genomic organization of the region where thekdrmutation resides and then performed polymerase chain reaction (PCR) and sequencing ...
Ke Dong, Steven M. Valles, Mike E. Scharf, Brian Zeichner, Gary W. Bennett   +4 more
openaire   +1 more source