Results 261 to 270 of about 2,501,241 (289)

The molecular biology of knockdown resistance to pyrethroid insecticides

Insect Biochemistry and Molecular Biology, 2003
The term "knockdown resistance" is used to describe cases of resistance to diphenylethane (e.g. DDT) and pyrethroid insecticides in insects and other arthropods that result from reduced sensitivity of the nervous system. Knockdown resistance, first identified and characterized in the house fly (Musca domestica) in the 1950's, remains a threat to the ...
David M Söderlund
exaly   +3 more sources

Pyrethroids, knockdown resistance and sodium channels [PDF]

Pest Management Science, 2008
AbstractKnockdown resistance to DDT and the pyrethrins was first described in 1951 in the housefly (Musca domestica L.). This trait, which confers reduced neuronal sensitivity to these insecticides, was subsequently shown to confer cross‐resistance to all synthetic pyrethroid insecticides that have been examined to date. As a consequence, the worldwide
exaly   +3 more sources

Detection of L1014F knockdown resistance mutation in Culex tritaeniorhynchus populations

Pesticide Biochemistry and Physiology, 2022
Culex tritaeniorhynchus is a major Japanese encephalitis virus vector distributed in Southeast Asia and surrounding countries. The aim of the present study is to investigate insecticide resistance status among 10 Cx. tritaeniorhynchus populations of the Mediterranean region of Turkey.
Fatih Simsek, Sare Ilknur Yavasoglu, Fatma Bursali   +2 more
exaly   +3 more sources

Molecular studies of knockdown resistance to pyrethroids: cloning of domain II sodium channel gene sequences from insects

, 1997
Knockdown resistance (kdr) is a target-site resistance mechanism that confers nerve insensitivity to DDT and pyrethroid insecticides. In the housefly, Musca domestica, molecular cloning of the para-type sodium channel gene has revealed two amino acid ...
David Martínez-Torres
exaly   +2 more sources

C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy

Biochemical and Biophysical Research Communications, 2022
Insulin resistance (IR) attributed by the deficiency of lipophagy, is an abnormal state of downregulation of insulin-mediated glucose uptake and use into the liver. Chromosome 9 open reading frame 72 (C9orf72) variously modulates autophagy. We investigated the role and the downstream pathway of C9orf72 in hepatic IR.
Xiaomin, Cang, Yu, Wang, Jia, Zeng, Jingwen, Gao, Qianqian, Yu, Chunfeng, Lu, Feng, Xu, Jiaxi, Lin, Jinzhou, Zhu, Xueqin, Wang   +9 more
openaire   +2 more sources

TOP2A Knockdown Resensitizes Carfilzomib-Resistant Hmcls to Carfilzomib

Blood, 2015
Abstract Introduction/background: Multiple myeloma (MM) remains incurable despite the introduction of novel therapeutic agents. Microarray-based technologies were adopted in our study to determine if a genetic signature associated with resistance to carfilzomib, a second-generation proteasome inhibitor already in use in clinical settings,
A. Reale, T. Khong, S. Mithraprabhu, M. Ramachandran, I. Savvidou, A. Spencer   +5 more
openaire   +1 more source

The Knockdown Resistance (kdr) Mutation in Pyrethroid-Resistant German Cockroaches

Pesticide Biochemistry and Physiology, 1998
Abstract A point mutation in thepara-homologous sodium channel gene has been shown to be associated with knockdown resistance (kdr) in several insect species including the German cockroach. In this study, we analyzed the genomic organization of the region where thekdrmutation resides and then performed polymerase chain reaction (PCR) and sequencing ...
Ke Dong, Steven M. Valles, Mike E. Scharf, Brian Zeichner, Gary W. Bennett   +4 more
openaire   +1 more source

Knockdown of LMW-PTP enhances stress resistance in Caenorhabditis elegans

International Journal of Biological Macromolecules, 2018
Low molecular weight protein tyrosine phosphatase (LMW-PTP) is highly conserved across almost all living organisms and is involved in the modulation of a number of cellular proteins related to important signaling pathways. In this study, we isolated lmwptp (Y94H6A.7) of Caenorhabditis elegans, the homolog of human ACP1, and set up an effective feeding ...
Lin, Zhou, Lu, Wang, Shuju, Bai, Shu, Xing, Wannan, Li, Junfeng, Ma, Xueqi, Fu   +6 more
openaire   +2 more sources

Knockdown of UGT352A5 decreases the thiamethoxam resistance in Bemisia tabaci (Hemiptera: Gennadius)

International Journal of Biological Macromolecules, 2021
Uridine diphosphate (UDP)-glycosyltransferases (UGTs), which are major phase II detoxification enzymes, have been implicated in the glycosylation of lipophilic endobiotics and xenobiotics and thus potentially lead to the evolution of insecticide resistance. In this study, we identified and cloned two putative UGT genes from transcriptome data which are
Tianhua, Du, Buli, Fu, Xuegao, Wei, Cheng, Yin, Jing, Yang, Mingjiao, Huang, Jinjin, Liang, Peipan, Gong, Shaonan, Liu, Hu, Xue, Jinyu, Hu, Yongchao, Diao, Lianyou, Gui, Xin, Yang, Youjun, Zhang   +14 more
openaire   +2 more sources

Novel knockdown resistance mutations in human lice: artifacts or emerging resistance?

Trends in Parasitology
An exceptionally high number of novel mutations within domain II of the voltage-gated sodium channel have been reported in human lice from Iran and Saudi Arabia. We critically evaluate these reports, highlighting that many of them may be methodological artifacts, and urge rigorous confirmation before assigning biological significance.
Om P. Singh, Rajnikant Dixit, David Weetman   +2 more
openaire   +2 more sources