Results 61 to 70 of about 218,644 (293)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Implications of Bio-Efficacy and Persistence of Insecticides when Indoor Residual Spraying and Longlasting Insecticide Nets are Combined for Malaria Prevention [PDF]

, 2012
Bio-efficacy and residual activity of insecticides used for indoor residual spraying (IRS) and long-lasting insecticide nets (LLINs) were assessed against laboratory-reared and wild populations of the malaria vector, Anopheles arabiensis in south eastern
Ntamatungro, Alex J, Beatrice Chipwaza, Geoffrey Lingamba, Moore, Sarah J, Fredros O Okumu, Edgar Mbeyela, Moore, Jason, Mbeyela, Edgar, Madumla, Edith P, Kavishe, Deo R, Alex J Ntamatungro, Deo R Kavishe, Jason Moore, Lingamba, Geoffrey, Edith P Madumla, Sarah J Moore, Okumu, Fredros O, Chipwaza, Beatrice   +17 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

\ud Detection and Monitoring of Insecticide Resistance in Malaria Vectors in Tanzania Mainland\ud [PDF]

, 2011
\ud Vector control is a major component of the global strategy for malaria control which aims to prevent parasite transmission mainly through interventions targeting adult Anopheline vectors.
Kitau , J, Matowo , J, Kabula, B, Sindato , C, Mweya, C, Chacha , M, Massue , D, Tungu, P, Emidi , B, Batengana , B, Msangi , S, Malima , R, Magesa, S, Kisinza , W   +13 more
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors Aedes aegypti and Aedes albopictus from Malaysia

Parasites & Vectors, 2015
Background Knowledge on the extent, distribution and mechanisms of insecticide resistance is essential for successful insecticide-based dengue control interventions.
Intan H Ishak, Zairi Jaal, Hilary Ranson, Charles S Wondji   +3 more
doaj   +1 more source

Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway

Journal of Translational Medicine, 2018
Background Hypoxia-mediated chemoresistance has been regarded as an important obstacle in the development of cancer treatment. Knockdown of krüppel-like factor 5 (KLF5) was reported to inhibit hypoxia-induced cell survival and promote cell apoptosis in ...
Tianxiao Gong, Liuqing Cui, Haili Wang, Haoxun Wang, Na Han   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Comparability between insecticide resistance bioassays for mosquito vectors : time to review current methodology? [PDF]

, 2015
Insecticides play an integral role in the control of mosquito-borne diseases. With resistance to insecticides on the rise, surveillance of the target population for optimal choice of insecticides is a necessity.
Müller, Pie, Malone, David, David Malone, Owusu, Henry F, Jančáryová, Danica, Henry F Owusu, Pie Müller, Owusu, Henry F., Danica Jančáryová   +8 more
core   +1 more source

Relationship between Knockdown Resistance, Metabolic Detoxification and Organismal Resistance to Pyrethroids in Anopheles sinensis

PLoS ONE, 2013
Anopheles sinensis is the most important vector of malaria in Southeast Asia, including China. Currently, the most effective measure to prevent malaria transmission relies on vector control through the use of insecticides, primarily pyrethroids. Extensive use of insecticides poses strong selection pressure on mosquito populations for resistance ...
Zhong, Daibin, Chang, Xuelian, Zhou, Guofa, He, Zhengbo, Fu, Fengyang, Yan, Zhentian, Zhu, Guoding, Xu, Tielong, Bonizzoni, Mariangela, Wang, Mei-Hui, Cui, Liwang, Zheng, Bin, Chen, Bin, Yan, Guiyun, Terenius, Olle   +14 more
openaire   +7 more sources