Results 51 to 60 of about 107,528 (262)

Effects of Pilot Oil Injection Timing on Combustion, Covariance and Knocking of a Natural Gas–Diesel Duel-Fuel Low-Speed Engine

Polish Maritime Research
Dual-fuel engines, which are powered by natural gas while using a small amount of diesel for ignition, have become an attractive option in the marine sector due to their fuel flexibility and relatively good emission characteristics.
Wei Cunfeng, Chen Xiang-Xiang, Chen Liang, Li Pengfei, Liu Mingrui   +4 more
doaj   +1 more source

Low-Friction and -Knocking Diesel Engine Cylindrical-Tapered Bore Profile Design

Energies
To reduce the friction loss and the piston-knocking noise from the perspective of the design of the cylinder bore profile, the piston-ring cylinder bore (PRCB) dynamic model of an L6 diesel engine was developed using AVL-Excite-Piston & Rings.
Junhong Zhang, Ning Wang, Jian Wang, Hui Wang, Xueling Zhang, Huwei Dai, Jiewei Lin   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

“Knock, Knock. Who’s There?”

Ars Aequi, 2022
Wat te doen als je op Twitter door een anoniem profiel voor rotte vis wordt uitgemaakt? Het Nederlandse recht biedt verschillende mogelijkheden om identificerende gegevens te verkrijgen van internettussenpersonen. Maar hoe wordt de afweging met de bescherming van de persoonsgegevens van de anonymus gemaakt?
openaire   +3 more sources

Heavy Knocking Suppression and NO_X Emission Reduction by Means of Port Water Injection on a CFR SI Engine

Energies
The energy transition in the transportation sector makes hydrogen a promising candidate as a fuel for internal combustion engines; however, its tendency to knock limits its use to lean mixtures, resulting in a reduction in performance.
Emiliano Pipitone, Giuseppe Ingrassia, Michele Agueci   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Knock Knock

Indian Journal of Nephrology, 2023
Sethi, Jasmine, Subramani, Vignesh
openaire   +2 more sources