Results 71 to 80 of about 254,216 (351)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
La tècnica del port knocking [PDF]
, 2013 L'objectiu principal d'aquest projecte és realitzar un estudi sobre la tècnica del port knocking. Per tal d'assolir aquest objectiu definirem el concepte de port knocking i veurem en quines situacions ens convé aplicar aquesta tècnica i quina de les ...
Madrid Claramunt, Lluís
core
The Knocking in the Gas Dual-fuel Engine with Liquid LPG Injection into the Intake Manifold
International Journal of Mechanical Engineering and Robotics Research, 2021 This article deals with a detection of the knocking in the gas dual-fuel engine converted from the original Cummins diesel (compression ignition – CI) engine.
R. Procházka +3 more
semanticscholar +1 more source
Protoparvovirus Knocking at the Nuclear Door
Viruses, 2017 Protoparvoviruses target the nucleus due to their dependence on the cellular reproduction machinery during the replication and expression of their single-stranded DNA genome.
Elina Mäntylä +2 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Intelligent Door Knocking Security System Using IOT
, 2021 In current day security is very important. Nowadays, in all places many robberies are going on. In this security issue, lock is the major parameter. The trustworthy on the lock should me made improve.
et. al., Dr. T. J.Nagalakshmi ,
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Acta Pharmaceutica Sinica B, 2019 Blocking the programmed death-ligand 1 (PD-L1) on tumor cells with monoclonal antibody therapy has emerged as powerful weapon in cancer immunotherapy. However, only a minority of patients presented immune responses in clinical trials.
Huan Deng +9 more
semanticscholar +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source