Results 131 to 140 of about 739,130 (263)

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Dog Kamich Knockout

Kimich Knockout, a two-year-old pug, is shown as he demonstrates the long stay in the obedience training classes conducted by the Fort Worth Dog Training Club at El Zorro Kennels. Knockout is owned by Mr. and Mrs. W. E.

core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

NOX4 knockout inhibits cell migration and invasion.

, 2017
(A, B) NOX4 knockout inhibits the cell migration of HeLa cells. Equal numbers of cells were plated onto a 6 well plate, and cells were scraped. After 24 h and 48 h, the wound gaps were photographed using an inverted microscope and quantified using imageJ
Minsu Jang (2817730), Andrew J. Morris (206326), Junsoo Park (147202), Naser Jafari (3666577), Rackhyun Park (735914), Cai Huang (106394), Liqing Li (1584388), Hyunju Kim (124616)   +7 more
core   +1 more source

Cardiac-specific Trim44 knockout in rat attenuates isoproterenol-induced cardiac remodeling via inhibition of AKT/mTOR pathway

Disease Models & Mechanisms, 2023
Xiao-yu Jiang, Fei-fei Guan, Jia-xin Ma, Wei Dong, Xiao-long Qi, Xu Zhang, Wei Chen, Shan Gao, Xiang Gao, Shuo Pan, Ji-zheng Wang, Yuan-wu Ma, Lian-feng Zhang, Dan Lu   +13 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo. [PDF]

FEBS Open Bio
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Yao S, Archetti M.
europepmc   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Slow in Motion but Smart in Learning and Memory: Behavioral Changes in Adult NR3A Knockout Mice [PDF]

, 2011
The expression of NMDA receptor subunit NR3A is high in the neonatal brain but low in adults. However, its functional role in the adult brain is obscure.
Shan Ping Yu, Ling Wei, Osama Mohamad, Mingke Song   +3 more
core  

Physiological parameters of Cav2.2-knockout mice.

, 2019
A: PAS-stained sections of wild type and knockout mice kidneys. Magnification: ×100 (left column) and ×400 (middle and right column). B: Body weight (BW) and kidney weight (KW) of wild type and knockout mice before (Pre) and 14 days after UUO (Post ...
Shunsuke Takahashi (619660), Yoriaki Kaneko (2626213), Akito Maeshima (2626207), Keiichiro Mishima (7481051), Keiju Hiromura (2626216), Toru Sakairi (2626210), Hidekazu Ikeuchi (2626219), Masao Nakasatomi (6433679), Yoshihisa Nojima (184788)   +8 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source