Results 151 to 160 of about 739,130 (263)

Flying Fortress, "Knockout Dropper"

, 1939
Black and white photograph showing a Boeing Flying Fortress (Knockout Dropper)

core  

Structural Control of Stromal-Immune Coupling by COL24A1 Underlies Pregnancy Maintenance. [PDF]

Adv Sci (Weinh)
Wu T, Xie L, Liu W, Mo H, Xie C, Tang J, Wang Z, Lan P, Zhang J, Gao J, Tang Q, Cao C, Chen H.   +12 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Knockout reactions at CEBAF

, 1986
First run knockout experiments in the quasi-free region at CEBAF are ...
BOFFI, SIGFRIDO, PACATI, FRANCODAVIDE, GIUSTI, CARLOTTA   +2 more
core  

Loss of lactate dehydrogenase A disrupts R-loop homeostasis and induces DNA damage in breast cancer cells. [PDF]

Front Genet
Li S, Xu C, Chen S, Yin G, Yang D.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells. [PDF]

Adv Sci (Weinh)
Xu Z, Zhang X, Dong F, Shen N, Zhou J, Xi Z, Wu Z.   +6 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A genome-wide CRISPR knockout screen identified host genes essential for Brucella invasion and intracellular survival. [PDF]

Emerg Microbes Infect
Wang X, Wu S, Ding Y, Ding J, Li P, Lian Z.   +5 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source