Results 31 to 40 of about 739,130 (263)

Dental and periodontal phenotype in sclerostin knockout mice. [PDF]

, 2014
Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear.
Heimel, Patrick, Michaela Kneissel, Patrick Heimel, Schwarze, Uwe, Gruber, Reinhard, Dobsak, Toni, Toni Dobsak, Reinhard Gruber, Schwarze, Uwe Y, Uwe Y Schwarze, Dieter D Bosshardt, Ulrike Kuchler, Bosshardt, Dieter, Kneissel, Michaela, Kuchler, Ulrike, Dosak, Toni   +15 more
core   +2 more sources

Targeted Gene Mutation in Phytophthora spp.

Molecular Plant-Microbe Interactions, 2006
The genus Phytophthora belongs to the oomycetes and is composed of plant pathogens. Currently, there are no strategies to mutate specific genes for members of this genus.
Kurt H. Lamour, Ledare Finley, Oscar Hurtado-Gonzales, Daniel Gobena, Melinda Tierney, Harold J. G. Meijer   +5 more
doaj   +1 more source

eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. [PDF]

, 2012
All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation ...
Sabine Grüner, Ostermeier Eva, Ostermeier, Eva, Bernhard Nieswandt, Huang Paul L., Angelika Schröttle, Georg Ertl, Ertl, Georg, Ulrich Hoffmann, Peter J Kuhlencordt, Kuhlencordt Peter J., Huang, Paul, Nieswandt Bernhard, Schröttle Angelika, Grüner, Sabine, Huang, Paul L., Paul L Huang, Ponnuswamy, Padmapriya, Schröttle, Angelika, Ertl Georg, Hoffmann Ulrich, Hoffmann, Ulrich, Padmapriya Ponnuswamy, Nieswandt, Bernhard, Grüner Sabine, Ponnuswamy Padmapriya, Kuhlencordt, Peter J., Eva Ostermeier   +27 more
core   +2 more sources

knockout rat model

, 2021
Background Recent developments in gene editing, using transcriptional activator-like effector nucleases (TALENs), have greatly helped the generation of genetically engineered animal models.
Ji Min Lee, Takashi Yamamoto, Yang, Hyokyung, Lee, Ji Min, Jae‐Hak Park, Jin Kim, Kim, Jin, Ryu, Bokyeong, Hyokyung Yang, Kim, Ukjin, Bokyeong Ryu, Tetsushi Sakuma, Park, Jae-Hak, Yamamoto, Takashi, Ukjin Kim, Sakuma, Tetsushi   +15 more
core   +1 more source

Reduced Levels of Brain-Derived Neurotrophic Factor Affect Body Weight, Brain Weight and Behavior

Biology
Neurotrophins, which belong to the family of growth factors, not only play crucial roles during development but are also involved in many processes in the postnatal brain.
Matthias Wilhelm Voigt, Jens Schepers, Jacqueline Haas, Oliver von Bohlen und Halbach   +3 more
doaj   +1 more source

IgLON5 deficiency produces behavioral alterations in a knockout mouse model

Frontiers in Immunology
BackgroundAnti-IgLON5 disease is a neurological disorder characterized by autoantibodies against IgLON5 and pathological evidence of neurodegeneration. IgLON5 is a cell adhesion molecule of unknown function that is highly expressed in the brain.
Jon Landa, Ana Beatriz Serafim, Mercedes Alba, Estibaliz Maudes, Laura Molina-Porcel, Laura Molina-Porcel, Anna Garcia-Serra, Francesco Mannara, Josep Dalmau, Josep Dalmau, Josep Dalmau, Josep Dalmau, Francesc Graus, Lidia Sabater, Lidia Sabater   +14 more
doaj   +1 more source

Hyperprolactinemia in a male pituitary androgen receptor knockout mouse is associated with female‐like lactotroph development

, 2021
Background: Circulating prolactin concentration in rodents and humans is sexually dimorphic. Oestrogens are a well-characterised stimulator of prolactin release.
Christian, HC, Le Tissier, P, Smith, LB, Helen C. Christian, O’Hara, L, Paul Le Tissier, Lee B. Smith, Laura O’Hara   +7 more
core   +1 more source

Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research

Biomolecules
Severe combined immunodeficient (SCID) mice serve as a critical model for human xenotransplantation studies, yet they often suffer from low engraftment rates and susceptibility to graft-versus-host disease (GVHD).
Yixiao Bin, Sanhua Wei, Ruo Chen, Haowei Zhang, Jing Ren, Peijuan Liu, Zhiqian Xin, Tianjiao Zhang, Haijiao Yang, Ke Wang, Zhuan Feng, Xiuxuan Sun, Zhinan Chen, Hai Zhang   +13 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source