Results 21 to 30 of about 739,130 (263)

Modeling and simulation of the main metabolism in Escherichia coli and its several single-gene knockout mutants with experimental verification [PDF]

, 2010
Peer ...
Ahmad A Mannan, Kadir Tuty, Kazuyuki Shimizu, Andrzej M Kierzek, Tuty Asmawaty Abdul Kadir, McFadden, J, Kadir, TAA, Kadir, Tuty Asmawaty Abdul, Shimizu, K, Kierzek, AM, Kierzek, Andrzej M, Shimizu, Kazuyuki, Kierzek, Andrzej M., McFadden Johnjoe, Mannan, AA, Johnjoe McFadden, Kadir, TA, Mannan, Ahmad A., McFadden, Johnjoe, Shimizu Kazuyuki, Mannan, Ahmad A, Abdul Kadir, Tuty Asmawaty, Mannan Ahmad A, Kierzek Andrzej M, Tuty Kadir   +24 more
core   +1 more source

The Establishment of a CSF-Contacting Nucleus “Knockout” Model Animal

Frontiers in Neuroanatomy, 2018
To establish an entirely cerebrospinal fluid (CSF)-contacting nucleus-deficient model animal, we used cholera toxin B subunit (CB)- saporin (SAP), which is an analog of CB-HRP that specifically labels the CSF-contacting nucleus, to exclusively damage the
Si-Yuan Song, Li-Cai Zhang
doaj   +1 more source

Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet

Lipids in Health and Disease, 2022
Background Hepatocyte nuclear factor 4α (HNF4α) and glucocorticoid receptor (GR), master regulators of liver metabolism, are down-regulated in fatty liver diseases. The present study aimed to elucidate the role of down-regulation of HNF4α and GR in fatty
Hong Lu, Xiaohong Lei, Rebecca Winkler, Savio John, Devendra Kumar, Wenkuan Li, Yazen Alnouti   +6 more
doaj   +1 more source

The tobacco chloroplast YCF4 gene is essential for transcriptional gene regulation and plants photoautotrophic growth

Frontiers in Plant Science, 2022
A tobacco chloroplast hypothetical open reading frame 4 (YCF4) has been reported as a non-essential assembly factor for photosynthesis based on an incomplete knockout of YCF4, just 93 of 184 amino acids from the N-terminus were knocked out.
Muhammad Sarwar Khan, Rimsha Riaz, Muhammad Majid, Kashif Mehmood, Ghulam Mustafa, Faiz Ahmad Joyia   +5 more
doaj   +1 more source

Analysis of enamel development using murine model systems: approaches and limitations.

Frontiers in Physiology, 2014
A primary goal of enamel research is to understand and potentially treat or prevent enamel defects related to amelogenesis imperfecta (AI). Rodents are ideal models to assist our understanding of how enamel is formed because they are easily genetically ...
Megan K Pugach, Carolyn W Gibson
doaj   +1 more source

P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles

Frontiers in Pharmacology, 2022
Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral ...
Robin M. H. Rumney, Justyna Róg, Natalia Chira, Alexander P. Kao, Rasha Al-Khalidi, Dariusz C. Górecki, Dariusz C. Górecki   +6 more
doaj   +1 more source

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. [PDF]

, 2010
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan.
Soppo, Charlotte Blanche Ekalle, Martin Klingenspor, Eugenio Scanziani, Hrabě de Angelis, M., Fabrizio Bianchi, Di Fiore, Pier Paolo, B. Pozzi, Offenhäuser Nina, Martin Hrabé de Angelis, Klingenspor Martin, B. Rathkolb, Horsch Marion, Horsch, Marion, Rathkolb, B., Nicole Ehrhardt, Wolf Eckhard, V. Gailus Durner, Tacchetti Carlo, Beckers, Johannes, Jan Rozman, Gailus-Durner, Valérie, Ralf Elvert, Hrabé de Angelis, Martin, Wolf, E., Ehrhardt, Nicole, Johannes Beckers, Elvert, Ralf, Tocchetti, Arianna, Pier Paolo Di Fiore, F. Bianchi, Elvert, R., A. Tocchetti, Horsch, M., Klingenspor, Martin, Bianchi, F., Moerth Corinna, Carlo Tacchetti, Ehrhardt Nicole, Pozzi, Benedetta, Scanziani Eugenio, Gagliani, M.C., Offenhäuser, N., Bianchi Fabrizio, Giorgio Scita, Birgit Rathkolb, M. C. Gagliani, Ehrhardt, N., Scita, G., Fuchs, Helmut, di Fiore, P.P., J. Beckers, Zani Fabio, Corinna Moerth, Eckhard Wolf, de Angelis Martin Hrabé, Mörth, C., Pozzi, B., Fuchs Helmut, M. Klingenspor, Beckers Johannes, M. Horsch, Tacchetti, C., Nina Offenhäuser, Rathkolb, Birgit, G. Scita, Tacchetti, Carlo, Bianchi, Fabrizio, Rozman, J., Rozman, Jan, Maria Cristina Gagliani, Charlotte Blanche Ekalle Soppo, Arianna Tocchetti, Ekalle Soppo Charlotte Blanche, Zani, F., N. Ehrhardt, Fuchs, H., J. Rozman, P.P. Di Fiore, Soppo, C.B.E., Valérie Gailus-Durner, Gailus-Durner, V., Gagliani, Maria Cristina, Moerth, Corinna, E. Scanziani, Scanziani, Eugenio, Helmut Fuchs, N. Offenhäuser, C. Tacchetti, Offenhäuser, Nina, Scita, Giorgio, Fabio Zani, C. Moerth, E. Wolf, Tocchetti, A., Elvert Ralf, Di Fiore Pier Paolo, M. Hrabé de Angelis, Tocchetti Arianna, Beckers, J., F. Zani, C. B. Soppo, Gagliani Maria Cristina, Scita Giorgio, Zani, Fabio, Scanziani, E., Klingenspor, M., Rathkolb Birgit, R. Elvert, Marion Horsch, Benedetta Pozzi, Pozzi Benedetta, Gailus-Durner Valérie, Wolf, Eckhard, Rozman Jan, H. Fuchs   +114 more
core   +2 more sources

Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity

Frontiers in Neuroscience, 2019
Major depressive disorder (MDD) is the most prevalent mental illness contributing to global disease burden. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are the first-line treatment for MDD, but are only fully effective in 30% of patients and ...
Faranak Vahid-Ansari, Min Zhang, Amin Zahrai, Paul R. Albert   +3 more
doaj   +1 more source

Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength [PDF]

, 2012
Osteoporosis is a common polygenic disease and global healthcare priority but its genetic basis remains largely unknown. We report a high-throughput multi-parameter phenotype screen to identify functionally significant skeletal phenotypes in mice ...
Gogakos Apostolos, Campbell, MJ, Anne H. van der Spek (145990), Campbell Michael J., Gogakos, A, Sunter, D, Williams, GR, David Sunter, Bassett, JHD, Boyde, A, Michael J. Campbell (5833), Sunter, D., Richard M Jacques, Project, S.M.G., Alan Boyde (146008), Croucher Peter I., Ramirez-Solis, R, Williams, G.R., Richard M. Jacques (145985), van der Spek Anne H., Holly Evans (145980), Bassett, J.H.D., Ryder, E, Edward Ryder (145998), Peter I. Croucher (146016), Graham R Williams, Evans, H, Bassett J. H. Duncan, Jacques, RM, Anne H van der Spek, J. H. Duncan Bassett (145971), Croucher, PI, Peter I Croucher, Project, SMG, Ryder, E., David Sunter (146002), Holly Evans, Gogakos, A., Jacqueline K. White (119191), Apostolos Gogakos (145975), Ramirez-Solis, R., Jacqueline K White, White Jacqueline K., Boyde, A., van der Spek, A.H., Evans, H., Michael J Campbell, Ramirez-Solis Ramiro, White, J.K., Jacques, R.M., J H Duncan Bassett, Apostolos Gogakos, Jacques Richard M., Croucher, P.I., Ryder Edward, Graham R. Williams (20148), Campbell, M.J., Evans Holly, Ramiro Ramirez-Solis (119181), Williams Graham R., Ramiro Ramirez-Solis, Edward Ryder, Alan Boyde, van der Spek, AH, Sanger Mouse Genetics Project, Sunter David, White, JK, Boyde Alan   +67 more
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A Novel Pale-Yellow Coat Color of Rabbits Generated viaMC1R Mutation With CRISPR/Cas9 System

Frontiers in Genetics, 2019
Coat color is of great importance in animal breed characteristics; it is not only a significant productive trait but also an indispensable economic trait, especially in the rabbit industry.
Ning Xiao, Hongli Li, Laiba Shafique, Shanshan Zhao, Xiaoping Su, Yu Zhang, Kuiqing Cui, Qingyou Liu, Deshun Shi   +8 more
doaj   +1 more source