Results 1 to 10 of about 612,335 (120)

Can a fighter develop glass jaw? Statistical evidence from mixed martial arts

open access: yesRevista de Artes Marciales Asiáticas, 2023
This paper deals with a phenomenon in combat sports called the glass jaw or glass chin. It is the ability of a fighter to withstand punches to the jaw area without falling unconscious and thus receiving a knockout. The main objective of this paper is to
Vojtech Kotrba
doaj   +1 more source

Genetic Inhibition of Plppr5 Aggravates Hypoxic-Ischemie-Induced Cortical Damage and Excitotoxic Phenotype

open access: yesFrontiers in Neuroscience, 2022
Hypoxia-ischemia (HI) is the most common acute brain threat in neonates and a leading cause of neurodevelopmental impairment. Exploring the new molecular mechanism of HI brain injury has important clinical translational significance for the next clinical
Yuxiao Sun   +6 more
doaj   +1 more source

Nos2 deficiency enhances carbon tetrachloride-induced liver injury in aged mice [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2020
Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4).
Deming Li   +7 more
doaj   +1 more source

Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation

open access: yesmBio, 2021
We previously reported that herpes simplex virus 1 (HSV-1) ICP22 binds to CD80 and suppresses CD80 expression in vitro and in vivo. Similar to ICP22, the cellular costimulatory molecules CD28, CTLA4, and PD-L1 also bind to CD80.
Harry H. Matundan   +4 more
doaj   +1 more source

Utilizing cell-free DNA to validate targeted disruption of MYO7A in rhesus macaque pre-implantation embryos

open access: yesJournal of Animal Reproduction and Biotechnology, 2022
Direct injection of CRISPR/Cas9 into zygotes enables the production of genetically modified nonhuman primates (NHPs) essential for modeling specific human diseases, such as Usher syndrome, and for developing novel therapeutic strategies.
Junghyun Ryu   +5 more
doaj   +1 more source

Small Heterodimer Partner Modulates Macrophage Differentiation during Innate Immune Response through the Regulation of Peroxisome Proliferator Activated Receptor Gamma, Mitogen-Activated Protein Kinase, and Nuclear Factor Kappa B Pathways

open access: yesBiomedicines, 2023
Hepatic macrophages act as the liver’s first line of defense against injury. Their differentiation into proinflammatory or anti-inflammatory subpopulations is a critical event that maintains a delicate balance between liver injury and repair.
Forkan Ahamed   +4 more
doaj   +1 more source

Replication Study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

open access: yeseLife, 2018
As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Lesnik et al., 2016) that described how we intended to replicate selected experiments from the paper ‘Melanoma exosomes educate bone marrow progenitor cells toward a
Jeewon Kim   +6 more
doaj   +1 more source

WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives

open access: yesCells, 2021
The WW domain-containing oxidoreductase (WWOX) gene was originally discovered as a putative tumor suppressor spanning the common fragile site FRA16D, but as time has progressed the extent of its pleiotropic function has become apparent.
Daniel J. Steinberg, Rami I. Aqeilan
doaj   +1 more source

System-Based Approaches to Delineate the Antiviral Innate Immune Landscape

open access: yesViruses, 2020
Viruses pose substantial challenges for society, economy, healthcare systems, and research. Their distinctive pathologies are based on specific interactions with cellular factors.
Karsten Krey   +2 more
doaj   +1 more source

Effect and mechanism of vanin-1 knockout in promoting recovery of kidney function after renal ischemia reperfusion injury in mice

open access: yesDi-san junyi daxue xuebao, 2021
Objective To explore the expression level of vascular noninflammatory molecule-1 (Vanin-1) in renal tissue after renal ischemia-reperfusion (I/R) injury and its relationship with the recovery of renal function.
WANG Ling   +6 more
doaj   +1 more source

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