Results 1 to 10 of about 612,335 (120)
Can a fighter develop glass jaw? Statistical evidence from mixed martial arts
This paper deals with a phenomenon in combat sports called the glass jaw or glass chin. It is the ability of a fighter to withstand punches to the jaw area without falling unconscious and thus receiving a knockout. The main objective of this paper is to
Vojtech Kotrba
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Hypoxia-ischemia (HI) is the most common acute brain threat in neonates and a leading cause of neurodevelopmental impairment. Exploring the new molecular mechanism of HI brain injury has important clinical translational significance for the next clinical
Yuxiao Sun +6 more
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Nos2 deficiency enhances carbon tetrachloride-induced liver injury in aged mice [PDF]
Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4).
Deming Li +7 more
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Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation
We previously reported that herpes simplex virus 1 (HSV-1) ICP22 binds to CD80 and suppresses CD80 expression in vitro and in vivo. Similar to ICP22, the cellular costimulatory molecules CD28, CTLA4, and PD-L1 also bind to CD80.
Harry H. Matundan +4 more
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Direct injection of CRISPR/Cas9 into zygotes enables the production of genetically modified nonhuman primates (NHPs) essential for modeling specific human diseases, such as Usher syndrome, and for developing novel therapeutic strategies.
Junghyun Ryu +5 more
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Hepatic macrophages act as the liver’s first line of defense against injury. Their differentiation into proinflammatory or anti-inflammatory subpopulations is a critical event that maintains a delicate balance between liver injury and repair.
Forkan Ahamed +4 more
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As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Lesnik et al., 2016) that described how we intended to replicate selected experiments from the paper ‘Melanoma exosomes educate bone marrow progenitor cells toward a
Jeewon Kim +6 more
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WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives
The WW domain-containing oxidoreductase (WWOX) gene was originally discovered as a putative tumor suppressor spanning the common fragile site FRA16D, but as time has progressed the extent of its pleiotropic function has become apparent.
Daniel J. Steinberg, Rami I. Aqeilan
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System-Based Approaches to Delineate the Antiviral Innate Immune Landscape
Viruses pose substantial challenges for society, economy, healthcare systems, and research. Their distinctive pathologies are based on specific interactions with cellular factors.
Karsten Krey +2 more
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Objective To explore the expression level of vascular noninflammatory molecule-1 (Vanin-1) in renal tissue after renal ischemia-reperfusion (I/R) injury and its relationship with the recovery of renal function.
WANG Ling +6 more
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