Results 1 to 10 of about 1,863,148 (392)

Knockout Mouse Models for Peroxiredoxins [PDF]

Antioxidants, 2020
Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain intracellular reactive oxygen species (ROS) homeostasis. The family members are expressed in most organisms and involved in various biological processes, such as ...
Young Jae Lee
doaj   +4 more sources

The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. [PDF]

Scientific Reports, 2016
The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases. Here, we sought to determine the specific role of TSPO in experimental autoimmune encephalomyelitis (EAE), the most studied animal model of multiple sclerosis (MS).
Chechneva, Olga, Daugherty, Daniel J, Deng, Wenbin, Mayrhofer, Florian   +3 more
core   +2 more sources

Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line

Scientific Reports, 2018
Mutations in PARK2 (parkin) can result in Parkinson’s disease (PD). Parkin shares a bidirectional promoter with parkin coregulated gene (PACRG) and the transcriptional start sites are separated by only ~200 bp.
Sarah E. M. Stephenson, Timothy D. Aumann, Juliet M. Taylor, Jessica R. Riseley, Ruili Li, Jeffrey R. Mann, Doris Tomas, Paul J. Lockhart   +7 more
doaj   +2 more sources

Rapid knockout and reporter mouse line generation and breeding colony establishment using EUCOMM conditional-ready embryonic stem cells: A case study

Frontiers in Endocrinology, 2015
As little as a decade ago, generation of a single knockout mouse line was an expensive and time-consuming undertaking available to relatively few researchers. The International Knockout Mouse Consortium, established in 2007, has revolutionized the use of
James L. J. Coleman, James L. J. Coleman, Karen eBrennan, Tony eNgo, Tony eNgo, Poornima eBalaji, Poornima eBalaji, Robert M. Graham, Robert M. Graham, Nicola J Smith, Nicola J Smith   +10 more
doaj   +2 more sources

Generation and characterization of a knockout mouse of an enhancer of EBF3 [PDF]

Biology Open
Emily Cordova Hurtado, Janine M. Wotton, Alexander Gulka, Crystal Burke, Jeffrey K. Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A. Murray, David U. Gorkin, Jacqueline K. White, Kevin A. Peterson, Tychele N. Turner   +12 more
doaj   +2 more sources

Altered Neurocircuitry in the Dopamine Transporter Knockout Mouse Brain [PDF]

, 2010
The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters.
A Bonci, A Dedeoglu, A Drobyshevsky, A Hammers, A Madabhushi, A Mechelli, A Naressi, A Pfefferbaum, A Sidhu, A Van der Linden, A van Doorn, AC Silva, AJ Mcdonald, B Giros, Benoit Boulat, BJ Everitt, C Rorden, CA Heidbreder, CC Brun, CE John, CG Van Eden, CR Gerfen, D LeBihan, D Ongur, DB Carr, DC Alexander, DE Comings, DL Rothman, DW Shattuck, E-F Lee, EJ Nestler, EK Miller, EL Bearer, EL Bearer, Elaine L. Bearer, F. Scott Hall, G Paxinos, G Paxinos, G Sanacora, George R. Uhl, GF Koob, GR Uhl, H Ratiney, HC Brenhouse, HJ Groenewegen, HP Hetherington, HW Dong, HW Shen, I Aoki, I Sora, I Sora, I Tkac, I Tkáč, IHA Franken, IK Lyoo, J Broman, J Chen, J Drago, J Hennig, J Kassubek, J Mattiello, J Tanji, JC Lau, JG Sled, JM Tyszka, JV Trinh, JYF Wong, K Narita, KC Chan, KM Hasan, KM Hurley, L Chen, L Goncalves, L Yavich, M Cyr, M Marjanska, M Rudin, M Yamashita, MA Ariano, MG Caron, ML Mundorf, N Kovacevic, N Lepore, N Papadakis, ND Volkow, Olivier Jacques Manzoni, P Drapeau, P Kochunov, P Satpute-Krishnan, PA Bottomley, PG Morris, PJ Basser, PJW Pouwels, PK Thanos, PLA Gabbott, PR Hof, PW Kalivas, R Bosse, R Gainetdinov, R Gruetter, R Kalisch, R Spanagel, R Verma, RG Elluru, RG Pautler, RJ Ralph, RM Rodriguiz, RP Carson, RR Gainetdinov, RR Gainetdinov, RR Gainetdinov, RR Gainetdinov, Russell E. Jacobs, S Canals, S Jones, S Kida, S Mori, S Spring, SB Brian Ross, SB Floresco, SG Amara, SH Snyder, SK Song, SN Haber, T Watanabe, TW Robbins, U Wieshmann, V Govindaraju, WC Drevets, Xiaowei Zhang, XX Zhuang, Y Ma, Y Murayama, Y Shinonaga   +133 more
core   +20 more sources

A conditional knockout resource for the genome-wide study of mouse gene function

Nature, 2011
William C. Skarnes, Barry P. Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David K. Jackson, Jessica Severin, Patrick J. Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley   +17 more
openalex   +3 more sources

The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease

Nucleic Acids Res., 2022
The International Mouse Phenotyping Consortium (IMPC; https://www.mousephenotype.org/) web portal makes available curated, integrated and analysed knockout mouse phenotyping data generated by the IMPC project consisting of 85M data points and over 95,000
T. Groza, Federico López-Gómez, Hamed Haseli Mashhadi, Violeta Muñoz-Fuentes, O. Günes, Robert J. Wilson, P. Cacheiro, Anthony Frost, Piia Keskivali-Bond, Bora Vardal, Aaron McCoy, Tsz Kwan Cheng, Luis A. Santos, S. Wells, D. Smedley, A. Mallon, Helen E. Parkinson   +16 more
semanticscholar   +1 more source

Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention

Brain : a journal of neurology, 2021
Mitochondria are small cellular constituents that generate cellular energy (ATP) by oxidative phosphorylation (OXPHOS). Dysfunction of these organelles is linked to a heterogeneous group of multisystemic disorders, including diabetes, cancer, ageing ...
M. A. van de Wal, M. Adjobo-Hermans, J. Keijer, T. Schirris, J. Homberg, M. Wieckowski, S. Grefte, E. V. van Schothorst, C. V. van Karnebeek, Albert Quintana, W. Koopman   +10 more
semanticscholar   +1 more source

Potential of PKM2 as a drug target in mouse models with type 1 diabetes mellitus

Immunity, Inflammation and Disease, 2022
Background This study aimed to determine the effect of PKM2 knockout in STZ induced type 1 diabetes mellitus (T1D) mouse models and to explore the possible mechanism.
Junbin Liu, Zhixia Li, Gan Huang, Zhiguang Zhou, Peilin Zheng   +4 more
doaj   +1 more source