Results 1 to 10 of about 406,670 (317)
Knockout Mouse Models for Peroxiredoxins [PDF]
Antioxidants, 2020 Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain intracellular reactive oxygen species (ROS) homeostasis. The family members are expressed in most organisms and involved in various biological processes, such as ...
Young Jae Lee
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Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line [PDF]
Scientific Reports, 2018 Mutations in PARK2 (parkin) can result in Parkinson’s disease (PD). Parkin shares a bidirectional promoter with parkin coregulated gene (PACRG) and the transcriptional start sites are separated by only ~200 bp.
Sarah E. M. Stephenson +7 more
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Targeting the mouse genome: a compedium of knockouts
Current Biology, 1995 AbstractThe following omissions and errors in the entries up to the end of 1994 had come to light as of 1st September 1995. The on-line version of the tables in the June, July and August issues of Current Biology, (1995:625–634; 758–765; 873–881), have been left as published in the journals.
Eugene P. Brandon +2 more
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Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes [PDF]
Scientific Reports, 2022 We searched a database of single-gene knockout (KO) mice produced by the International Mouse Phenotyping Consortium (IMPC) to identify candidate ciliopathy genes.
Kendall Higgins +35 more
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Potential of PKM2 as a drug target in mouse models with type 1 diabetes mellitus
Immunity, Inflammation and Disease, 2022 Background This study aimed to determine the effect of PKM2 knockout in STZ induced type 1 diabetes mellitus (T1D) mouse models and to explore the possible mechanism.
Junbin Liu +4 more
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Cells, 2022 Sirtuins (SIRT1–7 in mammals) are evolutionarily conserved nicotinamide adenine dinucleotide-dependent lysine deacetylases/deacylases that regulate fundamental biological processes including aging.
Tomoya Mizumoto +10 more
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The eIF2A knockout mouse [PDF]
Cell Cycle, 2016 Eukaryotic initiation factor 2A (eIF2A) is a 65-kDa protein that was first identified in the early 1970s as a factor capable of stimulating initiator methionyl-tRNAi (Met-tRNAMeti) binding to 40S ribosomal subunits in vitro. However, in contrast to the eIF2, which stimulates Met-tRNAMeti binding to 40S ribosomal subunits in a GTP-dependent manner ...
Artyom Kojukhov +7 more
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The Knockout Mouse Project [PDF]
Nature Genetics, 2004 Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes.
Geoff Hicks +40 more
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Objective hearing threshold identification from auditory brainstem response measurements using supervised and self-supervised approaches [PDF]
BMC Neurosci 23, 81 (2022), 2021 Hearing loss is a major health problem and psychological burden in humans. Mouse models offer a possibility to elucidate genes involved in the underlying developmental and pathophysiological mechanisms of hearing impairment. To this end, large-scale mouse phenotyping programs include auditory phenotyping of single-gene knockout mouse lines.
arxiv +1 more source
NeuroSci, 2021 Null mice for the dopamine D2 receptor (D2R) have been instrumental in understanding the function of this protein. For our research, we obtained the functional D2R knockout mouse strain described initially in 1997.
Natalia Sánchez +9 more
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