Results 1 to 10 of about 415,720 (292)
Knockout Mouse Models for Peroxiredoxins [PDF]
Antioxidants, 2020 Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain intracellular reactive oxygen species (ROS) homeostasis. The family members are expressed in most organisms and involved in various biological processes, such as ...
Young Jae Lee
doaj +3 more sources
Potential of PKM2 as a drug target in mouse models with type 1 diabetes mellitus
Immunity, Inflammation and Disease, 2022 Background This study aimed to determine the effect of PKM2 knockout in STZ induced type 1 diabetes mellitus (T1D) mouse models and to explore the possible mechanism.
Junbin Liu +4 more
doaj +1 more source
Cells, 2022 Sirtuins (SIRT1–7 in mammals) are evolutionarily conserved nicotinamide adenine dinucleotide-dependent lysine deacetylases/deacylases that regulate fundamental biological processes including aging.
Tomoya Mizumoto +10 more
doaj +1 more source
NeuroSci, 2021 Null mice for the dopamine D2 receptor (D2R) have been instrumental in understanding the function of this protein. For our research, we obtained the functional D2R knockout mouse strain described initially in 1997.
Natalia Sánchez +9 more
doaj +1 more source
Role of ZBED3 in cortex cerebral development through conventional Zbed3 knockout mouse [PDF]
Jichu yixue yu linchuang, 2020 Objective To explore the role of zinc finger BED domain-containing protein 3, a member of zinc finger domain protein superfamily, in cortex cerebral development through conventional Zbed3 knockout mouse.
SUN Chang-jie, SHU Peng-cheng, PENG Xiao-zhong
doaj
Reduced body weight is a common effect of gene knockout in mice
BMC Genetics, 2008 Background During a search for obesity candidate genes in a small region of the mouse genome, we noticed that many genes when knocked out influence body weight.
Lawler Maureen P +2 more
doaj +1 more source
C1q as a target molecule to treat human disease: What do mouse studies teach us?
Frontiers in Immunology, 2022 The complement system is a field of growing interest for pharmacological intervention. Complement protein C1q, the pattern recognition molecule at the start of the classical pathway of the complement cascade, is a versatile molecule with additional non ...
Kristina Schulz +3 more
doaj +1 more source
Double Deletion of PI3K and PTEN Modifies Lens Postnatal Growth and Homeostasis
Cells, 2022 We have previously shown that the conditional deletion of either the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K), or its opposing phosphatase, phosphatase and tensin homolog (PTEN), had distinct effects on lens growth and homeostasis.
Caterina Sellitto +2 more
doaj +1 more source
Frontiers in Endocrinology, 2015 As little as a decade ago, generation of a single knockout mouse line was an expensive and time-consuming undertaking available to relatively few researchers. The International Knockout Mouse Consortium, established in 2007, has revolutionized the use of
James L. J. Coleman +10 more
doaj +1 more source
Divergent Roles of Central Serotonin in Adult Hippocampal Neurogenesis
Frontiers in Cellular Neuroscience, 2017 The central serotonin (5-HT) system is the main target of selective serotonin reuptake inhibitors (SSRIs), the first-line antidepressants widely used in current general practice.
Ning-Ning Song +12 more
doaj +1 more source