Results 131 to 140 of about 1,863,148 (392)

Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice

Journal of Lipid Research, 2004
Scavenger receptor class B type I (SR-BI) has been identified as a functional HDL binding protein that can mediate the selective uptake of cholesteryl ester (CE) from HDL.
Ruud Out, Menno Hoekstra, John A.A. Spijkers, Johan K. Kruijt, Miranda van Eck, Ingrid S.T. Bos, Jaap Twisk, Theo J.C. Van Berkel   +7 more
doaj   +1 more source

Predicting the lethal phenotype of the knockout mouse by integrating comprehensive genomic data [PDF]

, 2012
Yuan Yuan, Yanxun Xu, Jianfeng Xu, Robyn L. Ball, Han Liang   +4 more
openalex   +1 more source

The mammalian gene function resource: the international knockout mouse consortium

Mammalian Genome, 2012
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action.
A. Bradley, K. Anastassiadis, A. Ayadi, J. Battey, C. Bell, M. Birling, Joanna Bottomley, Steve D. M. Brown, Antje Bürger, C. Bult, Wendy Bushell, F. Collins, C. Desaintes, B. Doe, A. Economides, J. Eppig, R. Finnell, R. Finnell, C. Fletcher, M. Fray, D. Frendewey, Roland H. Friedel, R. Friedel, F. Grosveld, Jens Hansen, Y. Hérault, G. Hicks, A. Hörlein, Richard Houghton, M. H. Angelis, D. Huylebroeck, V. Iyer, P. Jong, J. Kadin, Cornelia Kaloff, K. Kennedy, M. Koutsourakis, K. C. K. Lloyd, S. Marschall, J. Mason, C. McKerlie, M. P. McLeod, H. V. Melchner, Mark W. Moore, A. Mujica, A. Mujica, A. Nagy, M. Nefedov, L. Nutter, G. Pavlovic, J. Peterson, J. Pollock, R. Ramírez‐Solís, D. Rancourt, M. Raspa, J. Remacle, M. Ringwald, B. Rosen, N. Rosenthal, J. Rossant, P. R. Noppinger, Edward Ryder, J. Schick, F. Schnütgen, P. Schofield, C. Seisenberger, M. Selloum, E. Simpson, W. Skarnes, D. Smedley, D. Smedley, W. Stanford, A. F. Stewart, Kevin R. Stone, Kate Swan, Hamsa D. Tadepally, L. Teboul, G. Tocchini-Valentini, D. Valenzuela, A. West, K. Yamamura, Y. Yoshinaga, W. Wurst, W. Wurst   +83 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Mouse Models of Genetically Altered Peroxiredoxin 6

Antioxidants, 2019
Peroxiredoxin 6 (Prdx6) has been shown to have three enzymatic activities: peroxidase, phospholipase A2 (PLA2) and acyl transferase. The peroxidase activity is unusual, as it is capable of reducing phospholipid hydroperoxides (as well as hydrogen ...
Sheldon I. Feinstein
doaj   +1 more source

Distinct mixtures of muscarinic receptor subtypes mediate inhibition of noradrenaline release in different mouse peripheral tissues, as studied with receptor knockout mice [PDF]

, 2005
Anne‐Ulrike Trendelenburg, Angelika Meyer, Jürgen Wess, Klaus Starke   +3 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Functional muscle analysis of the Tcap knockout mouse [PDF]

, 2010
Chad D. Markert, Mary Pat Meaney, Kevin A. Voelker, Robert W. Grange, H. W. Dalley, Jennifer K. Cann, Maryam Ahmed, B. Bishwokarma, Stephen J. Walker, S. X. Yu, M. Brown, Michael W. Lawlor, Alan H. Beggs, Martin K. Childers   +13 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Hyperglycemic Ins2AkitaLdlr−/− mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease[S]

Journal of Lipid Research, 2011
Accelerated atherosclerosis is the leading cause of death in type 1 diabetes, but the mechanism of type 1 diabetes-accelerated atherosclerosis is not well understood, in part due to the lack of a good animal model for the long-term studies required.
Changcheng Zhou, Brian Pridgen, Nakesha King, Jinxian Xu, Jan L. Breslow   +4 more
doaj   +1 more source