Results 131 to 140 of about 406,670 (317)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Comparative impacts of glutathione peroxidase-1 gene knockout on oxidative stress induced by reactive oxygen and nitrogen species in mouse hepatocytes [PDF]

, 2001
Yang‐Xin Fu, Jesús M. Porres, Xin Gen Lei   +2 more
openalex   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Defects in inositol 1,4,5-trisphosphate receptor expression, Ca ²⁺ signaling, and insulin secretion in the anx 7(+/−) knockout mouse

, 1999
Meera Srivastava, I. Atwater, Mirta Glasman, Ximena Leighton, G. Goping, H. Caohuy, Georgina Miller, José G. Pichel, Heiner Westphal, David Mears, Eduardo Rojas, Harvey B. Pollard   +11 more
openalex   +1 more source

Sequential analysis of kidney stone formation in the Aprt knockout mouse [PDF]

, 2001
Andrew P. Evan, Sharon B. Bledsoe, Bret A. Connors, Li Deng, Li Liang, Changshun Shao, Naomi S. Fineberg, Marc D. Grynpas, P J Stambrook, Youzhi Shao, Amrik Sahota, Jay A. Tischfield   +11 more
openalex   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Gene expression in mice with endothelium-specific telomerase knockout

Frontiers in Cell and Developmental Biology, 2023
Zhanguo Gao, Yongmei Yu, Yulin Dai, Zhongming Zhao, Kristin Eckel-Mahan, Mikhail G. Kolonin   +5 more
doaj   +1 more source

The Adhesion Modulating Properties of Tenascin-W

International Journal of Biological Sciences, 2012
Tenascins are extracellular matrix glycoproteins associated with cell motility, proliferation and differentiation. Tenascin-C inhibits cell spreading by binding to fibronectin; tenascin-R and tenascin-X also have anti-adhesive properties in vitro.
Florence Brellier, Enrico Martina, Matthias Chiquet, Jacqueline Ferralli, Michael van der Heyden, Gertraud Orend, Johannes C. Schittny, Ruth Chiquet-Ehrismann, Richard P. Tucker
doaj  

Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse. [PDF]

Mol Psychiatry, 2023
Park JS, Heo H, Kim MS, Lee SE, Park S, Kim KH, Kang YH, Kim JS, Sung YH, Shim WH, Kim DH, Song Y, Yoon SY.   +12 more
europepmc   +1 more source

AAV-Mediated Delivery of Ciliary Neurotrophic Factor Prolongs Photoreceptor Survival in the Rhodopsin Knockout Mouse [PDF]

, 2001
Fong-Qi Liang, Nadine S. Dejneka, Daniel R. Cohen, Natalia V. Krasnoperova, Janis Lem, Albert M. Maguire, Lorita Dudus, Krishna J. Fisher, Jean Bennett   +8 more
openalex   +1 more source