Results 141 to 150 of about 415,720 (292)

Generation of the floxed allele of the SIP1 (Smad‐interacting protein 1) gene for Cre‐mediated conditional knockout in the mouse [PDF]

, 2002
Yujiro Higashi, Mitsuji Maruhashi, L Nelles, Tom Van de Putte, Kristin Verschueren, Tomoya Miyoshi, Aki Yoshimoto, Hisato Kondoh, Danny Huylebroeck   +8 more
openalex   +1 more source

Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients.
Patrizia Pignataro, Manuela Dicarlo, Chiara Zecca, Daniele Urso, Maria Teresa Dell'Abate, Davide Vilella, Francesco Borlizzi, Roberta Zerlotin, Angela Oranger, Graziana Colaianni, Silvia Colucci, Maria Grano, Giancarlo Logroscino   +12 more
wiley   +1 more source

Knockout mouse models as a resource for the study of rare diseases. [PDF]

Mamm Genome, 2023
da Silva-Buttkus P, Spielmann N, Klein-Rodewald T, Schütt C, Aguilar-Pimentel A, Amarie OV, Becker L, Calzada-Wack J, Garrett L, Gerlini R, Kraiger M, Leuchtenberger S, Östereicher MA, Rathkolb B, Sanz-Moreno A, Stöger C, Hölter SM, Seisenberger C, Marschall S, Fuchs H, Gailus-Durner V, Hrabě de Angelis M.   +21 more
europepmc   +1 more source

Molecular pharmacology of prostaglandin E receptor subtypes –structure, signal transduction, and knockout mouse studies–

, 2000
Atsushi Ichikawa, Yukihiko Sugimoto, Masahiko Negishi, Shu Narumiya   +3 more
openalex   +1 more source

Glial Fibrillary Acidic Protein Astrocytopathy Based on a Two‐Center Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glial fibrillary acidic protein astrocytopathy (GFAP‐A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment, and prognosis of a GFAP‐A cohort from two centers in China.
Ti Wu, Hao Zhang, Chao Gao, Qiuhua Yu, Moli Fan, Lin‐Jie Zhang, Haipeng Zhang, Hengri Cong, Yuzhen Wei, Chotima Böttcher, Alexej Verkhratsky, Friedemann Paul, Fu‐Dong Shi, Tian Song   +13 more
wiley   +1 more source

Slc35a2 mosaic knockout impacts cortical development, dendritic arborisation, and neuronal firing

Neurobiology of Disease
Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an important cause of drug-resistant epilepsy. A significant subset of individuals diagnosed with MOGHE display somatic mosaicism for loss-of-function ...
James Spyrou, Khaing Phyu Aung, Hannah Vanyai, Richard J. Leventer, Snezana Maljevic, Paul J. Lockhart, Katherine B. Howell, Christopher A. Reid   +7 more
doaj  

Down but not out? A novel protein isoform of the estrogen receptor alpha is expressed in the estrogen receptor alpha knockout mouse [PDF]

, 2002
Martin Koš, S. Denger, George Reid, Kenneth S. Korach, Frank Gannon   +4 more
openalex   +1 more source

In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock, Jihyun Park, Dae‐Gyu Jang, Bangyao Zhao, Samuel J. Teener, Ian F. Webber‐Davis, Lili Zhao, Eva L. Feldman, Stephen A. Goutman   +8 more
wiley   +1 more source

Immune Phenotypic Characterization of a TRAIL-Knockout Mouse. [PDF]

Cancers (Basel), 2023
Stoyanova AK, Sattler A, Hahn EM, Hering NA, Arndt M, Lauscher JC, Speichinger-Hillenberg F, Kotsch K, Berg AK, Beyer K.   +9 more
europepmc   +1 more source

Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis

, 2001
Robert E. Fleming, Christopher Holden, Shunji Tomatsu, Abdül Waheed, Elizabeth M. Brunt, Robert S. Britton, Bruce R. Bacon, Derry C. Roopenian, William S. Sly   +8 more
openalex   +1 more source