Results 11 to 20 of about 625,707 (357)
Potential of PKM2 as a drug target in mouse models with type 1 diabetes mellitus
Immunity, Inflammation and Disease, 2022 Background This study aimed to determine the effect of PKM2 knockout in STZ induced type 1 diabetes mellitus (T1D) mouse models and to explore the possible mechanism.
Junbin Liu +4 more
doaj +1 more source
Cells, 2022 Sirtuins (SIRT1–7 in mammals) are evolutionarily conserved nicotinamide adenine dinucleotide-dependent lysine deacetylases/deacylases that regulate fundamental biological processes including aging.
Tomoya Mizumoto +10 more
doaj +1 more source
Objective hearing threshold identification from auditory brainstem response measurements using supervised and self-supervised approaches [PDF]
BMC Neurosci 23, 81 (2022), 2021 Hearing loss is a major health problem and psychological burden in humans. Mouse models offer a possibility to elucidate genes involved in the underlying developmental and pathophysiological mechanisms of hearing impairment. To this end, large-scale mouse phenotyping programs include auditory phenotyping of single-gene knockout mouse lines.
arxiv +1 more source
NeuroSci, 2021 Null mice for the dopamine D2 receptor (D2R) have been instrumental in understanding the function of this protein. For our research, we obtained the functional D2R knockout mouse strain described initially in 1997.
Natalia Sánchez +9 more
doaj +1 more source
Role of ZBED3 in cortex cerebral development through conventional Zbed3 knockout mouse [PDF]
Jichu yixue yu linchuang, 2020 Objective To explore the role of zinc finger BED domain-containing protein 3, a member of zinc finger domain protein superfamily, in cortex cerebral development through conventional Zbed3 knockout mouse.
SUN Chang-jie, SHU Peng-cheng, PENG Xiao-zhong
doaj
Reduced body weight is a common effect of gene knockout in mice
BMC Genetics, 2008 Background During a search for obesity candidate genes in a small region of the mouse genome, we noticed that many genes when knocked out influence body weight.
Lawler Maureen P +2 more
doaj +1 more source
The Ebf1 knockout mouse and glomerular maturation [PDF]
Kidney International, 2014 Mice deficient in the transcription factor early B-cell factor 1 (Ebf1) lack mature B lymphocytes but have additional phenotypes suggesting functions outside the hematopoietic system. Fretz et al. report that these mice also exhibit quantitative and qualitative developmental renal defects and develop progressive podocyte foot process effacement.
Kai M. Schmidt-Ott, Kai M. Schmidt-Ott
openaire +4 more sources
Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]
, 2008 Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Ando +72 more
core +1 more source
Evolutionarily conserved human targets of adenosine to inosine RNA editing [PDF]
Nucleic Acids Research, Vol. 33, 1162-1168 (2005), 2005 A-to-I RNA editing by ADARs is a post-transcriptional mechanism for expanding the proteomic repertoire. Genetic recoding by editing was so far observed for only a few mammalian RNAs that are predominantly expressed in nervous tissues. However, as these editing targets fail to explain the broad and severe phenotypes of ADAR1 knockout mice, additional ...
arxiv +1 more source
C1q as a target molecule to treat human disease: What do mouse studies teach us?
Frontiers in Immunology, 2022 The complement system is a field of growing interest for pharmacological intervention. Complement protein C1q, the pattern recognition molecule at the start of the classical pathway of the complement cascade, is a versatile molecule with additional non ...
Kristina Schulz +3 more
doaj +1 more source