Results 11 to 20 of about 415,720 (292)

Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line [PDF]

Scientific Reports, 2018
Mutations in PARK2 (parkin) can result in Parkinson’s disease (PD). Parkin shares a bidirectional promoter with parkin coregulated gene (PACRG) and the transcriptional start sites are separated by only ~200 bp.
Sarah E. M. Stephenson, Timothy D. Aumann, Juliet M. Taylor, Jessica R. Riseley, Ruili Li, Jeffrey R. Mann, Doris Tomas, Paul J. Lockhart   +7 more
doaj   +5 more sources

Targeting the mouse genome: a compedium of knockouts

Current Biology, 1995
AbstractThe following omissions and errors in the entries up to the end of 1994 had come to light as of 1st September 1995. The on-line version of the tables in the June, July and August issues of Current Biology, (1995:625–634; 758–765; 873–881), have been left as published in the journals.
Eugene P. Brandon, Rejean L. Idzerda, G. Stanley McKnight   +2 more
openalex   +3 more sources

The Knockout Mouse Project [PDF]

Nature Genetics, 2004
Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes.
Geoff Hicks, Susan M. Dymecki, D. Stewart, Mark W. Moore, Jonathan D. Pollock, James F. Battey, Stephen G. Young, Terry Magnuson, Christopher P. Austin, Geoffrey M. Duyk, Arthur T. Sands, Kevin C K Lloyd, J.T. Eppig, Richard P. Woychik, Wolfgang Wurst, Harold E. Varmus, Inder M. Verma, Lyuba Varticovski, Jan A. Witkowski, Francis Stewart, Thomas F. Vogt, Philippe Soriano, William F. Dove, Bruce Stillman, Beverly H. Koller, Thomas R. Insel, George D. Yancopoulos, Andras Nagy, Alexandra L. Joyner, Jay Snoddy, William C. Skarnes, Franziska B. Grieder, Brian Zambrowicz, Harald von Melchner, Allan Bradley, Francis S. Collins, Brian Seed, Nathaniel Heintz, Allen D. Roses, Mario R. Capecchi, Maja Bucan   +40 more
openaire   +4 more sources

The eIF2A knockout mouse [PDF]

Cell Cycle, 2016
Eukaryotic initiation factor 2A (eIF2A) is a 65-kDa protein that was first identified in the early 1970s as a factor capable of stimulating initiator methionyl-tRNAi (Met-tRNAMeti) binding to 40S ribosomal subunits in vitro. However, in contrast to the eIF2, which stimulates Met-tRNAMeti binding to 40S ribosomal subunits in a GTP-dependent manner ...
Artyom Kojukhov, Maria Hatzoglou, Benjamin Morpurgo, Anton A. Komar, Andrei Golovko, William C. Merrick, Bo-Jhih Guan, Barsanjit Mazumder   +7 more
openaire   +3 more sources

The First Knockout Mouse Model of Retinoblastoma [PDF]

Cell Cycle, 2004
The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene identified in humans (Friend, et al., 1986) and the first tumor suppressor gene knocked out by targeted deletion in mice (Jacks, et al., Clarke, et al., Lee, et al., 1992).
Jiakun Zhang, Michael A. Dyer, Brett Schweers   +2 more
openaire   +4 more sources

The Ebf1 knockout mouse and glomerular maturation [PDF]

Kidney International, 2014
Mice deficient in the transcription factor early B-cell factor 1 (Ebf1) lack mature B lymphocytes but have additional phenotypes suggesting functions outside the hematopoietic system. Fretz et al. report that these mice also exhibit quantitative and qualitative developmental renal defects and develop progressive podocyte foot process effacement.
Kai M. Schmidt-Ott, Kai M. Schmidt-Ott
openaire   +4 more sources

Mouse anxiety: the power of knockout [PDF]

The Pharmacogenomics Journal, 2001
The role of the neurokinine 1 receptors (NK1R) and its endogenous ligand, the neuropeptide substance P (SP) in the pathophysiology and treatment response of anxiety and depression has been controversial. In a new study, however, mice with a targeted inactivation of the NK1R show a phenotype that is associated with anxiety-related behaviors and stress ...
openaire   +2 more sources

Impaired social behavior in 5-HT3A receptor knockout mice

Frontiers in Behavioral Neuroscience, 2010
The 5-HT3 receptor is a ligand-gated ion channel expressed on interneurons throughout the brain. So far, analysis of the 5-HT3A knockout mouse revealed changes in nociceptive processing and a reduction in anxiety related behavior.
Laura A Smit-Rigter, Wytse J Wadman, Johannes A Van Hooft   +2 more
doaj   +1 more source

Generation of an Armcx1 Conditional Knockout Mouse. [PDF]

Genesis
ABSTRACTArmadillo repeat‐containing X‐linked protein‐1 (Armcx1) is a poorly characterized transmembrane protein that regulates mitochondrial transport in neurons. Its overexpression has been shown to induce neurite outgrowth in embryonic neurons and to promote retinal ganglion cell (RGC) survival and axonal regrowth in a mouse optic nerve crush model ...
Bright CL, Bomze HM, Bhaumik M, Kay JN, Cartoni R, Gospe SM.   +5 more
europepmc   +3 more sources

Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning

Molecular Brain, 2020
Protrudin is a protein that resides in the membrane of the endoplasmic reticulum and is highly expressed in the nervous system. Although mutations in the human protrudin gene (ZFYVE27, also known as SPG33) give rise to hereditary spastic paraplegia (HSP),
Michiko Shirane, Hirotaka Shoji, Yutaka Hashimoto, Hiroyuki Katagiri, Shizuka Kobayashi, Toshiya Manabe, Tsuyoshi Miyakawa, Keiichi I. Nakayama   +7 more
doaj   +1 more source