Results 191 to 200 of about 415,720 (292)

Gene augmentation therapy attenuates retinal degeneration in a knockout mouse model of Fam161a retinitis pigmentosa. [PDF]

Mol Ther, 2023
Matsevich C, Gopalakrishnan P, Chang N, Obolensky A, Beryozkin A, Salameh M, Kostic C, Sharon D, Arsenijevic Y, Banin E.   +9 more
europepmc   +1 more source

Butyrylcholinesterase and acetylcholinesterase activity and quantal transmitter release at normal and acetylcholinesterase knockout mouse neuromuscular junctions [PDF]

, 2003
Jasmina Minic, Arnaud Chatonnet, Éric Krejci, Jordi Molgó   +3 more
openalex   +1 more source

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

Insight into mammary gland development and tumor progression in an E2F5 conditional knockout mouse model. [PDF]

Oncogene
To B, Broeker C, Jhan JR, Garcia-Lerena J, Vusich J, Rempel R, Rennhack JP, Hollern D, Jackson L, Judah D, Swiatnicki M, Bylett E, Kubiak R, Honeysett J, Nevins J, Andrechek E.   +15 more
europepmc   +1 more source

Low‐Activation Compositionally Complex Alloys for Advanced Nuclear Applications—A Review

Advanced Engineering Materials, EarlyView.
Low‐activation compositionally complex alloys (LACCAs) are advanced metallic materials primarily composed of low‐activation elements, offering advantages such as rapid compliance with operational standards and safe recyclability. This review highlights their potential for extreme high‐temperature irradiation environments as structural materials for ...
Yangfan Wang, Hanliang Zhu, Zhiyang Wang, Zhijun Qiu, Xiao Wang, Zengxi Pan, Hongtao Zhu, Mingxing Zhang, Huijun Li   +8 more
wiley   +1 more source

The Regulator of G Protein Signaling 14 Knockout Mouse, a Model of Healthful Longevity Protects Against Obesity and Glucose Intolerance Through a Brown Adipose Tissue Mechanism. [PDF]

Int J Mol Sci
Vatner SF, Zhang J, Oydanich M, Vatner DE.   +3 more
europepmc   +1 more source

Intestinal Cckbr-specific knockout mouse as a novel model of salt-sensitive hypertension via sodium over-absorption. [PDF]

J Geriatr Cardiol, 2023
Zhang QY, Guo Y, Jiang XL, Liu X, Zhao SG, Zhou XL, Yang ZW.   +6 more
europepmc   +1 more source

Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan disease [PDF]

, 2003
Reuben Matalon, Sankar Surendran, Peter L. Rady, Michael J. Quast, Gerald A. Campbell, Kimberlee Michals Matalon, Stephen K. Tyring, Jingna Wei, Carmen S. Peden, E.d L Ezell, Nicholas Muzyczka, Ronald J. Mandel   +11 more
openalex   +1 more source

Impact of Hot Isostatic Pressing on Microstructure Evolution and Creep Performance of Powder Bed Fusion–Laser Beam Processed CM247LC

Advanced Engineering Materials, EarlyView.
The influence of Hot Isostatic Pressing (HIP) temperature on the microstructure and creep performance of powder bed fusion–laser beam processed CM247LC superalloy is investigated. Grain growth and γ’ precipitate evolution are characterized following HIP at varying temperatures.
Ahmed Fardan, Johannes Gårdstam, Eva Oscarsson, Håkan Brodin, Eduard Hryha   +4 more
wiley   +1 more source

The A2ml1-Knockout mouse as an animal model for non-syndromic otitis media. [PDF]

Int J Pediatr Otorhinolaryngol
Elling CL, Gomez HZ, Lee NK, Hirsch SD, Santos-Cortez RLP.   +4 more
europepmc   +1 more source