Results 211 to 220 of about 415,720 (292)

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source

Erratum in: Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma. [PDF]

Invest Ophthalmol Vis Sci
europepmc   +1 more source

Role of ACSBG1 in Brain Lipid Metabolism and X-Linked Adrenoleukodystrophy Pathogenesis: Insights from a Knockout Mouse Model. [PDF]

Cells
Ye X, Li Y, González-Lamuño D, Pei Z, Moser AB, Smith KD, Watkins PA.   +6 more
europepmc   +1 more source

Intrinsic Hepatic Phenotype Associated with the Cyp1a2 Gene as Shown by cDNA Expression Microarray Analysis of the Knockout Mouse [PDF]

, 2003
A. G. Smith
openalex   +1 more source

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Self‐Cascade Catalytic Reaction–Assisted Apoptosis/Calcicoptosis/Ferroptosis Induction with Microsphere‐Aggregated Hydrogels in Triple‐Negative Breast Cancer Therapy

Advanced Functional Materials, EarlyView.
Hyaluronic acid‐dopamine‐based intra‐crosslinked microsphere including cisplatin (HPC MS) is fabricated by spray‐drying and calcium/iron ions are introduced for interparticle crosslinking. Designed microsphere‐aggregated hydrogel (MAH) system including cisplatin/CaO2/FeSO4 can provide apoptosis/calcicoptosis/ferroptosis‐mediated chemo/cascade ...
ChaeRim Hwang, Yeoung Eun Choi, Song Yi Lee, Mrinmoy Karmakar, Qiaojun Hao, Junmin Lee, Hyun‐Jong Cho   +6 more
wiley   +1 more source

Generation of Astrocyte-specific BEST1 Conditional Knockout Mouse with Reduced Tonic GABA Inhibition in the Brain. [PDF]

Exp Neurobiol
Joo J, Kim KJ, Lim J, Choi SY, Koh W, Lee CJ.   +5 more
europepmc   +1 more source

SIN-1, a nitric oxide synthase donor, reduces isoproterenol-stimulated calcium current in both wild type and genetically engineered mouse hearts: findings from G protein subunit gene knockout mice

, 2002
Fuhua Chen, Meisheng Jiang, Wei Sun, Lutz Birnbaumer, Glenn T. Wetzel   +4 more
openalex   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

Desipramine reverses remote memory deficits by activating calmodulin-CaMKII pathway in a UTX knockout mouse model of Kabuki syndrome. [PDF]

Gen Psychiatr
Chen L, Li Y, Liu M, Lan Z, Zhang X, Yang X, Zhao Q, Wang S, Xu L, Zhou Y, Kuang Y, Suzuki T, Tabuchi K, Takahashi E, Zhou M, Chen CD, Xu T, Li W.   +17 more
europepmc   +1 more source