Results 261 to 270 of about 415,720 (292)

Cancer and the knockout mouse

Nature, 1997
Telomeres are found at the end of linear chromosomes. They consist of DNA repeats that are synthesized by an enzyme called telomerase. Telomerase is not expressed in normal somatic cells, and inappropriate expression has been linked to the formation of tumours. To study the function of telomerase, knockout mice have been generated. Interestingly, these
Wynford-Thomas, D, Kipling, D
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The electroretinogram of the rhodopsin knockout mouse

Visual Neuroscience, 1999
The electroretinogram (ERG) of the rhodopsin knockout (rho−/−) mouse of Humphries et al. (1997) (Humphries et al., 1997) was studied for evidence of light-evoked rod activity and to describe the cone function. The rho−/− retina develops normal numbers of rod and cone nuclei, but the rods have no outer segments, and no rhodopsin is found by ...
Paul A. Sieving, Kazushige Toda, Ronald A. Bush, Peter Humphries   +3 more
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A new SGK1 knockout mouse [PDF]

American Journal of Physiology-Renal Physiology, 2008
the serum and glucocorticoid- regulated Kinase (SGK1) is a component of the pathway mediating activation of the epithelial sodium channel, ENaC, in the aldosterone-sensitive distal nephron (ASDN).
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Production of the Butyrylcholinesterase Knockout Mouse

Journal of Molecular Neuroscience, 2006
The butyrylcholinesterase (BChE [EC 3.1.1.8]) knockout mouse is a model for BChE deficiency in humans. The existence of genetic variants of human BChE was discovered after a new muscle relaxant, succinylcholine, was introduced into the practice of medicine in the late 1950s.
Ellen G. Duysen, Blin Li, Oksana Lockridge, Thomas L. Saunders   +3 more
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Learning and memory in theFMR1 knockout mouse

American Journal of Medical Genetics, 1999
The fragile X [fra(X)] syndrome is manifested phenotypically as a developmental disability comprised mainly of moderate-to-severe mental retardation (MR). Deficits are especially evident in auditory and visual short-term memory. Recently, an FMR1 knockout mouse developed by the Dutch-Belgian Fragile X Consortium demonstrated significantly lower visual ...
Cathy E. Bakker, Gene S. Fisch, Ben A. Oostra, Hui K. Hao   +3 more
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Knockout of one acetylcholinesterase allele in the mouse

Chemico-Biological Interactions, 1999
One allele of the AChE gene (ACHE) was knocked out in embryonic stem (ES) cells by homologous recombination. The targeting vector contained 2 kb of a TK gene cassette for negative selection, 884 bp of ACHE including exon 1, 1.6 kb of a Neo(r) gene cassette for positive selection, 5.2 kb of the ACHE Bam HI fragment including exon 6, and 3 kb of ...
Xie, W., Wilder, P.J., Stribley, J., Chatonnet, Arnaud, Rizzimo, A., Taylor, P., Hinrichs, S.H., Lockridge, O.   +7 more
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Knockout mouse model and gametogenic failure

Molecular and Cellular Endocrinology, 1998
To evaluate the function of a defined gene in gametogenesis, exciting opportunities are offered by the introduction of techniques to generate knockout mice. In this short article, we briefly describe a few gene knockout mouse models, which show a phenotype that involves impairment of gametogenesis and/or fertility.
J. Anton Grootegoed, Jan H.J. Hoeijmakers, Henk P. Roest, Willy M. Baarends   +3 more
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Knockout mouse models and mammary tumorigenesis

Seminars in Cancer Biology, 2001
The generation of transgenic mice overexpressing activated forms of oncogenes has greatly advanced our understanding into their roles in mammary tumor initiation, promotion and progression. However, targeted disruption of tumor suppressor genes often results in lethality at stages prior to mammary tumor formation.
Chu-Xia Deng, Steven G. Brodie
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Large‐scale mouse knockouts and phenotypes

WIREs Systems Biology and Medicine, 2012
AbstractStandardized phenotypic analysis of mutant forms of every gene in the mouse genome will provide fundamental insights into mammalian gene function and advance human and animal health. The availability of the human and mouse genome sequences, the development of embryonic stem cell mutagenesis technology, the standardization of phenotypic analysis
Edward Ryder, Jacqueline K. White, Joanna Bottomley, Ramiro Ramirez-Solis, Richard Houghton   +4 more
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