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The social deficits of the oxytocin knockout mouse
Neuropeptides, 2002Numerous studies have implicated oxytocin (OT) and oxytocin receptors in the central mediation of social cognition and social behavior. Much of our understanding of OT's central effects depends on pharmacological studies with OT agonists and antagonists.
J.T. Winslow, T.R. Insel
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Mouse Knockout Models of Hypertension
2005Gene-targeting technology allows the planned alteration of any gene in the mouse genome and has been very successfully employed to study the function of numerous gene products in a complete animal. The method includes the design of a suitable targeting construct, its transfection into pluripotential embryonic stem cells, selection for cells in which ...
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Nanomechanics of Knockout Mouse Bones
MRS Proceedings, 2006ABSTRACTOsteocalcin (OC) and osteopontin (OPN) are among the most abundant non-collagenous bone matrix proteins. Both have drawn interest from investigators studying their function in osteoporosis and it is known that mutations of these proteins can also have dramatic effects on the properties of bone.
Adrian B. Mann, N. Beril Kavukcuoglu
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Phenotype of the Taurine Transporter Knockout Mouse
2007This chapter reports present knowledge on the properties of mice with disrupted gene coding for the taurine transporter (taut-/- mice). Study of those mice unraveled some of the roles of taurine and its membrane transport for the development and maintenance of normal organ functions and morphology.
Helmut L. Haas +6 more
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Knockout mouse models of Hirschsprung’s disease
Pediatric Surgery International, 2015Hirschsprung's disease (HSCR) is a developmental disorder of the enteric nervous system, which occurs due to the failure of neural crest cell migration. Rodent animal models of aganglionosis have contributed greatly to our understanding of the genetic basis of HSCR.
Julia Zimmer, Prem Puri, Prem Puri
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Generation of GM130 Conditional Knockout Mouse
2022The Golgi apparatus is a common and highly dynamic organelle in eukaryotic cells. It plays an important role in secretory trafficking and cargo modifications. Increasing evidence suggests that structural changes and functional disorders of the Golgi apparatus are involved in many human diseases, but whether Golgi dysfunction is a causal factor in ...
Mei, Mei, Shilai, Bao
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Lessons from the adrenomedullin knockout mouse
Regulatory Peptides, 2003Because vasolidator peptide adrenomedullin (AM) exhibits complicated action, we developed AM knockout mice in order to elucidate the physiological and pathophysiological role of AM. The AM(-/-) mice were embryonic lethal, so we could not evaluate directly the role of AM in this mutant mice.
Toshiro Fujita, Katsuyuki Ando
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Knockout Mouse Models of Iron Homeostasis
Annual Review of Nutrition, 2011Murine models have made valuable contributions to our understanding of iron metabolism. Investigation of mice with inherited forms of anemia has led to the discovery of novel proteins involved in iron homeostasis. A growing number of murine models are being developed to investigate mitochondrial iron metabolism.
Qi Feng +2 more
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2001
Publisher Summary Telomeres are the ends of eukaryotic chromosomes and consist of tandem repeats of a G-rich DNA sequence, which in all the vertebrates is TTAGGG. Telomeres protect chromosome ends from degradation, recombination, and DNA repair activities.
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Publisher Summary Telomeres are the ends of eukaryotic chromosomes and consist of tandem repeats of a G-rich DNA sequence, which in all the vertebrates is TTAGGG. Telomeres protect chromosome ends from degradation, recombination, and DNA repair activities.
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Movement disorders in the Hfe knockout mouse
Nutritional Neuroscience, 2005The Hfe(- /-) mouse is a model for human hereditary hemochromatosis (HHH). The accumulation of tissue iron in this condition has led to the suggestion that HHH patients may be at higher risk for neurodegenerative diseases. In this study, adult male Hfe(-/-) mice and wildtype controls (n = 12/group) were evaluated for impairment with motor tests (stride
Kevin C K Lloyd +5 more
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