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Durable Proton Exchange Membrane Based on Polymers of Intrinsic Microporosity for Fuel Cells

Advanced Materials, EarlyView.
A novel composite proton exchange membrane (PEM) design that leverages carboxylic acid‐functionalized polymers of intrinsic microporosity (cPIM‐1) and polyvinylpyrrolidone (PVP). Harnessing Lewis acid‐base interactions enables the development of a synergistic microporous structure that confines phosphoric acid clusters, enhancing proton conductivity ...
Xiaochen Yang, Zhiming Feng, Mustafa Alshurafa, Ming Yu, Andrew B. Foster, Heng Zhai, Tianmu Yuan, Yiheng Xiao, Carmine D'Agostino, Ling Ai, Maria Perez‐Page, Keenan Smith, Fabrizia Foglia, Adam Lovett, Thomas S. Miller, Jianuo Chen, Peter M. Budd, Stuart M. Holmes   +17 more
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Cancer and the knockout mouse

Nature, 1997
Telomeres are found at the end of linear chromosomes. They consist of DNA repeats that are synthesized by an enzyme called telomerase. Telomerase is not expressed in normal somatic cells, and inappropriate expression has been linked to the formation of tumours. To study the function of telomerase, knockout mice have been generated. Interestingly, these
Wynford-Thomas, D, Kipling, D
openaire   +3 more sources

The electroretinogram of the rhodopsin knockout mouse

Visual Neuroscience, 1999
The electroretinogram (ERG) of the rhodopsin knockout (rho−/−) mouse of Humphries et al. (1997) (Humphries et al., 1997) was studied for evidence of light-evoked rod activity and to describe the cone function. The rho−/− retina develops normal numbers of rod and cone nuclei, but the rods have no outer segments, and no rhodopsin is found by ...
Paul A. Sieving, Kazushige Toda, Ronald A. Bush, Peter Humphries   +3 more
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Production of the Butyrylcholinesterase Knockout Mouse

Journal of Molecular Neuroscience, 2006
The butyrylcholinesterase (BChE [EC 3.1.1.8]) knockout mouse is a model for BChE deficiency in humans. The existence of genetic variants of human BChE was discovered after a new muscle relaxant, succinylcholine, was introduced into the practice of medicine in the late 1950s.
Ellen G. Duysen, Blin Li, Oksana Lockridge, Thomas L. Saunders   +3 more
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A new SGK1 knockout mouse [PDF]

American Journal of Physiology-Renal Physiology, 2008
the serum and glucocorticoid- regulated Kinase (SGK1) is a component of the pathway mediating activation of the epithelial sodium channel, ENaC, in the aldosterone-sensitive distal nephron (ASDN).
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Learning and memory in theFMR1 knockout mouse

American Journal of Medical Genetics, 1999
The fragile X [fra(X)] syndrome is manifested phenotypically as a developmental disability comprised mainly of moderate-to-severe mental retardation (MR). Deficits are especially evident in auditory and visual short-term memory. Recently, an FMR1 knockout mouse developed by the Dutch-Belgian Fragile X Consortium demonstrated significantly lower visual ...
Cathy E. Bakker, Gene S. Fisch, Ben A. Oostra, Hui K. Hao   +3 more
openaire   +4 more sources

Knockout of one acetylcholinesterase allele in the mouse

Chemico-Biological Interactions, 1999
One allele of the AChE gene (ACHE) was knocked out in embryonic stem (ES) cells by homologous recombination. The targeting vector contained 2 kb of a TK gene cassette for negative selection, 884 bp of ACHE including exon 1, 1.6 kb of a Neo(r) gene cassette for positive selection, 5.2 kb of the ACHE Bam HI fragment including exon 6, and 3 kb of ...
Xie, W., Wilder, P.J., Stribley, J., Chatonnet, Arnaud, Rizzimo, A., Taylor, P., Hinrichs, S.H., Lockridge, O.   +7 more
openaire   +5 more sources