Results 21 to 30 of about 406,670 (317)
Molecular Brain, 2020 Protrudin is a protein that resides in the membrane of the endoplasmic reticulum and is highly expressed in the nervous system. Although mutations in the human protrudin gene (ZFYVE27, also known as SPG33) give rise to hereditary spastic paraplegia (HSP),
Michiko Shirane +7 more
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Impaired social behavior in 5-HT3A receptor knockout mice
Frontiers in Behavioral Neuroscience, 2010 The 5-HT3 receptor is a ligand-gated ion channel expressed on interneurons throughout the brain. So far, analysis of the 5-HT3A knockout mouse revealed changes in nociceptive processing and a reduction in anxiety related behavior.
Laura A Smit-Rigter +2 more
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SIRT6 Knockout Cells Resist Apoptosis Initiation but Not Progression: A Computational Method to Evaluate the Progression of Apoptosis [PDF]
Apoptosis 22 (11), 1336-1343 (2017), 2017 Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis triggered by serum starvation. Specifically, we characterize the progression of apoptosis in wild type
arxiv +1 more source
Effect of the social environment on olfaction and social skills in WT and mouse model of autism [PDF]
arXiv, 2023 Autism spectrum disorders are complex, polygenic and heterogenous neurodevelopmental conditions, imposing a substantial economic burden. Genetics are influenced by the environment, specifically the social experience during the critical neurodevelopmental period.
arxiv
iScience, 2022 Summary: Overwriting counterselectable markers is an efficient strategy for removing wild-type DNA or replacing it with payload DNA of interest. Currently, one bottleneck of efficient genome engineering in mammals is the shortage of counterselectable ...
Weimin Zhang +9 more
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Generation of Human CRY1 and CRY2 Knockout Cells Using Duplex CRISPR/Cas9 Technology
Frontiers in Physiology, 2019 Circadian clocks are endogenous oscillators essential for orchestrating daily rhythms in physiology, metabolism and behavior. While mouse models have been instrumental to elucidate the molecular mechanism of circadian rhythm generation, our knowledge ...
Teresa Börding +10 more
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CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model
Laboratory Animal Research, 2018 Placenta specific 8 (PLAC8, also known as ONZIN) is a multi-functional protein that is highly expressed in the intestine, lung, spleen, and innate immune cells, and is involved in various diseases, including cancers, obesity, and innate immune deficiency.
HyunJeong Lee +6 more
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ODBAE: a high-performance model identifying complex phenotypes in high-dimensional biological datasets [PDF]
arXiv, 2022 Identifying complex phenotypes from high-dimensional biological data is challenging due to the intricate interdependencies among different physiological indicators. Traditional approaches often focus on detecting outliers in single variables, overlooking the broader network of interactions that contribute to phenotype emergence.
arxiv
Theoretical estimation of metabolic network robustness against multiple reaction knockouts using branching process approximation [PDF]
Physica A 392, 5525 (2013), 2013 In our previous study, we showed that the branching process approximation is useful for estimating metabolic robustness, measured using the impact degree. By applying a theory of random family forests, we here extend the branching process approximation to consider the knockout of {\it multiple} reactions, inspired by the importance of multiple ...
arxiv +1 more source
Mouse genetics: Catalogue and scissors [PDF]
BMB Reports, 2012 Phenotypic analysis of gene-specific knockout (KO) mice hasrevolutionized our understanding of in vivo gene functions. Asthe use of mouse embryonic stem (ES) cells is inevitable forconventional gene targeting, the generation of knockout miceremains a ...
Han-Woong Lee
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