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Knockout mouse model and gametogenic failure
Molecular and Cellular Endocrinology, 1998To evaluate the function of a defined gene in gametogenesis, exciting opportunities are offered by the introduction of techniques to generate knockout mice. In this short article, we briefly describe a few gene knockout mouse models, which show a phenotype that involves impairment of gametogenesis and/or fertility.
J. Anton Grootegoed +3 more
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Knockout mouse models and mammary tumorigenesis
Seminars in Cancer Biology, 2001The generation of transgenic mice overexpressing activated forms of oncogenes has greatly advanced our understanding into their roles in mammary tumor initiation, promotion and progression. However, targeted disruption of tumor suppressor genes often results in lethality at stages prior to mammary tumor formation.
Chu-Xia Deng, Steven G. Brodie
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The social deficits of the oxytocin knockout mouse
Neuropeptides, 2002Numerous studies have implicated oxytocin (OT) and oxytocin receptors in the central mediation of social cognition and social behavior. Much of our understanding of OT's central effects depends on pharmacological studies with OT agonists and antagonists.
J.T. Winslow, T.R. Insel
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Mouse Knockout Models of Hypertension
2005Gene-targeting technology allows the planned alteration of any gene in the mouse genome and has been very successfully employed to study the function of numerous gene products in a complete animal. The method includes the design of a suitable targeting construct, its transfection into pluripotential embryonic stem cells, selection for cells in which ...
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Large‐scale mouse knockouts and phenotypes
WIREs Systems Biology and Medicine, 2012AbstractStandardized phenotypic analysis of mutant forms of every gene in the mouse genome will provide fundamental insights into mammalian gene function and advance human and animal health. The availability of the human and mouse genome sequences, the development of embryonic stem cell mutagenesis technology, the standardization of phenotypic analysis
Edward Ryder +4 more
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Knockout mouse models of Hirschsprung’s disease
Pediatric Surgery International, 2015Hirschsprung's disease (HSCR) is a developmental disorder of the enteric nervous system, which occurs due to the failure of neural crest cell migration. Rodent animal models of aganglionosis have contributed greatly to our understanding of the genetic basis of HSCR.
Julia Zimmer, Prem Puri, Prem Puri
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Nanomechanics of Knockout Mouse Bones
MRS Proceedings, 2006ABSTRACTOsteocalcin (OC) and osteopontin (OPN) are among the most abundant non-collagenous bone matrix proteins. Both have drawn interest from investigators studying their function in osteoporosis and it is known that mutations of these proteins can also have dramatic effects on the properties of bone.
Adrian B. Mann, N. Beril Kavukcuoglu
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Generation of GM130 Conditional Knockout Mouse
2022The Golgi apparatus is a common and highly dynamic organelle in eukaryotic cells. It plays an important role in secretory trafficking and cargo modifications. Increasing evidence suggests that structural changes and functional disorders of the Golgi apparatus are involved in many human diseases, but whether Golgi dysfunction is a causal factor in ...
Mei, Mei, Shilai, Bao
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Phenotype of the Taurine Transporter Knockout Mouse
2007This chapter reports present knowledge on the properties of mice with disrupted gene coding for the taurine transporter (taut-/- mice). Study of those mice unraveled some of the roles of taurine and its membrane transport for the development and maintenance of normal organ functions and morphology.
Helmut L. Haas +6 more
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Lessons from the adrenomedullin knockout mouse
Regulatory Peptides, 2003Because vasolidator peptide adrenomedullin (AM) exhibits complicated action, we developed AM knockout mice in order to elucidate the physiological and pathophysiological role of AM. The AM(-/-) mice were embryonic lethal, so we could not evaluate directly the role of AM in this mutant mice.
Toshiro Fujita, Katsuyuki Ando
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