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Characterization of beta2-adrenergic receptor knockout mouse model during Chlamydia muridarum genital infection. [PDF]
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AJP - Renal Physiology, 2019
Diabetic Nephropathy (DN) is the most common cause of end-stage renal disease associated with high mortality worldwide. Increase in iron levels have been reported in the diabetic rat kidneys as well as in the human urine of diabetic patients. In addition,
K. Chaudhary +7 more
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Diabetic Nephropathy (DN) is the most common cause of end-stage renal disease associated with high mortality worldwide. Increase in iron levels have been reported in the diabetic rat kidneys as well as in the human urine of diabetic patients. In addition,
K. Chaudhary +7 more
semanticscholar +1 more source
Knockout mouse models of Hirschsprung’s disease
Pediatric Surgery International, 2015Hirschsprung's disease (HSCR) is a developmental disorder of the enteric nervous system, which occurs due to the failure of neural crest cell migration. Rodent animal models of aganglionosis have contributed greatly to our understanding of the genetic basis of HSCR.
Julia Zimmer, Prem Puri, Prem Puri
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Conditional knockout mouse models of cancer.
Cold Spring Harbor Protocols, 2014In 2007, three scientists, Drs. Mario R. Capecchi, Martin J. Evans, and Oliver Smithies, received the Nobel Prize in Physiology or Medicine for their contributions of introducing specific gene modifications into mice. This technology, commonly referred to as gene targeting or knockout, has proven to be a powerful means for precisely manipulating the ...
C. Deng
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American Journal of Physiology-Renal Physiology, 2008
the serum and glucocorticoid- regulated Kinase (SGK1) is a component of the pathway mediating activation of the epithelial sodium channel, ENaC, in the aldosterone-sensitive distal nephron (ASDN).
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the serum and glucocorticoid- regulated Kinase (SGK1) is a component of the pathway mediating activation of the epithelial sodium channel, ENaC, in the aldosterone-sensitive distal nephron (ASDN).
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Knockout mouse models and mammary tumorigenesis
Seminars in Cancer Biology, 2001The generation of transgenic mice overexpressing activated forms of oncogenes has greatly advanced our understanding into their roles in mammary tumor initiation, promotion and progression. However, targeted disruption of tumor suppressor genes often results in lethality at stages prior to mammary tumor formation.
C X, Deng, S G, Brodie
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Knockout mouse model and gametogenic failure
Molecular and Cellular Endocrinology, 1998To evaluate the function of a defined gene in gametogenesis, exciting opportunities are offered by the introduction of techniques to generate knockout mice. In this short article, we briefly describe a few gene knockout mouse models, which show a phenotype that involves impairment of gametogenesis and/or fertility.
Grootegoed, Anton +3 more
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Generation of GM130 Conditional Knockout Mouse
2022The Golgi apparatus is a common and highly dynamic organelle in eukaryotic cells. It plays an important role in secretory trafficking and cargo modifications. Increasing evidence suggests that structural changes and functional disorders of the Golgi apparatus are involved in many human diseases, but whether Golgi dysfunction is a causal factor in ...
Mei, Mei, Shilai, Bao
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Large‐scale mouse knockouts and phenotypes
WIREs Systems Biology and Medicine, 2012AbstractStandardized phenotypic analysis of mutant forms of every gene in the mouse genome will provide fundamental insights into mammalian gene function and advance human and animal health. The availability of the human and mouse genome sequences, the development of embryonic stem cell mutagenesis technology, the standardization of phenotypic analysis
Ramiro, Ramírez-Solis +4 more
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