Results 341 to 350 of about 1,863,148 (392)

Production of the Butyrylcholinesterase Knockout Mouse

Journal of Molecular Neuroscience, 2006
The butyrylcholinesterase (BChE [EC 3.1.1.8]) knockout mouse is a model for BChE deficiency in humans. The existence of genetic variants of human BChE was discovered after a new muscle relaxant, succinylcholine, was introduced into the practice of medicine in the late 1950s.
Bin, Li, Ellen G, Duysen, Thomas L, Saunders, Oksana, Lockridge   +3 more
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Lessons from the adrenomedullin knockout mouse

Regulatory Peptides, 2003
Because vasolidator peptide adrenomedullin (AM) exhibits complicated action, we developed AM knockout mice in order to elucidate the physiological and pathophysiological role of AM. The AM(-/-) mice were embryonic lethal, so we could not evaluate directly the role of AM in this mutant mice.
Katsuyuki, Ando, Toshiro, Fujita
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Mouse Knockout Models of Hypertension

2005
Gene-targeting technology allows the planned alteration of any gene in the mouse genome and has been very successfully employed to study the function of numerous gene products in a complete animal. The method includes the design of a suitable targeting construct, its transfection into pluripotential embryonic stem cells, selection for cells in which ...
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Knockout Mouse Models of Iron Homeostasis

Annual Review of Nutrition, 2011
Murine models have made valuable contributions to our understanding of iron metabolism. Investigation of mice with inherited forms of anemia has led to the discovery of novel proteins involved in iron homeostasis. A growing number of murine models are being developed to investigate mitochondrial iron metabolism.
Robert E, Fleming, Qi, Feng, Robert S, Britton   +2 more
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Fucosyltransferase-9 Knockout Mouse

2009
Stage-specific embryonic antigen-1 (SSEA-1), an antigenic epitope of which was defined as a Lewis x [Lex: Galβ1–4(Fucα1–3)GlcNAc-] carbohydrate structure, is widely expressed on the surface of mammalian cells, and is considered to be involved in cell-cell interactions during embryogenesis, differentiation, and neurodevelopmental processes.
Takashi Kudo, Hisashi Narimatsu
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Knockout Mouse Models in Pain Research

2004
Gene targeting in mice by homologous recombination is a powerful approach to study the role of specific genes in vivo. This technology is now applied to pain-related genes to understand molecular mechanisms of nociceptive behaviors. In this chapter, we provide detailed methodological information for the construction of knockout animals, exemplified by ...
Andrée, Dierich, Brigitte L, Kieffer
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Mouse Models: Knockouts/Knockins

2010
There is an enormous initiative to establish the genetic basis for addictive disorders. While forward genetic studies focus on identification of risk factors and protective genes impacting on addictive behaviors of humans and animal models, much effort is devoted to functions of these genes and polymorphisms relevant to substance abuse in reverse ...
Weihua Huang, Wenhao Xu, Ming D. Li
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Cancer and the knockout mouse

Nature, 1997
73201
Wynford-Thomas, D, Kipling, D
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Nanomechanics of Knockout Mouse Bones

MRS Proceedings, 2006
ABSTRACTOsteocalcin (OC) and osteopontin (OPN) are among the most abundant non-collagenous bone matrix proteins. Both have drawn interest from investigators studying their function in osteoporosis and it is known that mutations of these proteins can also have dramatic effects on the properties of bone.
N Beril Kavukcuoglu, Adrian B. Mann
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The telomerase knockout mouse

2001
Publisher Summary Telomeres are the ends of eukaryotic chromosomes and consist of tandem repeats of a G-rich DNA sequence, which in all the vertebrates is TTAGGG. Telomeres protect chromosome ends from degradation, recombination, and DNA repair activities.
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