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[Adrenergic receptor and knockout mouse: 1) Beta adrenergic receptor knockout mouse].

Masui. The Japanese journal of anesthesiology, 2001
Functional analysis of beta 1 and beta 2 adrenergic receptor (AR) subtypes has been made possible by establishing knockout mice (KO) with abolished beta 1 and/or beta 2 AR expression. Neither resting heart rate nor resting blood pressure of beta 1 AR KO, beta 2 AR KO, or beta 1/beta 2 KO differed significantly from those of wild-type mice.
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[Adrenergic receptor and knockout mouse: 2). Alpha adrenergic receptor knockout mouse].

Masui. The Japanese journal of anesthesiology, 2001
The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors which are known to have a critical role in regulating transmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.
openaire   +1 more source

[GM1-gangliosidosis knockout mouse].

No to hattatsu = Brain and development, 1998
We generated a beta-galactosidosis mouse by gene targeting in an embryonic stem cell. Clinical, pathological, and biochemical analyses revealed that this mouse is a useful animal model to study the pathogenesis and therapy of human GM1-gangliosidosis.
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The DARPP-32 knockout mouse

Brain Research Reviews, 2000
A A, Fienberg, P, Greengard
openaire   +2 more sources

Humanized mouse models for immuno-oncology research

Nature Reviews Clinical Oncology, 2023
Michael A Brehm
exaly  

[Knockout mouse--its characteristics and application (1): NMDA receptor subunit knockout mouse].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1998
The N-methyl-D-aspartate (NMDA) type of glutamate receptors is thought to be essential in many central actions of neurotransmitter glutamate, including learning, memory, neurodevelopment and neurodegenerative disorders. Recent molecular cloning has revealed that the NMDA receptor has multiple subunits with distinct distribution, properties and ...
openaire   +1 more source

Intratumoural administration and tumour tissue targeting of cancer immunotherapies

Nature Reviews Clinical Oncology, 2021
Ignacio Melero Bermejo   +2 more
exaly  

Synthetic alternatives to Matrigel

Nature Reviews Materials, 2020
Elizabeth A Aisenbrey, William L Murphy
exaly  

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