Results 31 to 40 of about 406,670 (317)
Absence of BBSome function leads to astrocyte reactivity in the brain
Molecular Brain, 2019 In humans, dysfunctional primary cilia result in Bardet-Biedl syndrome (BBS), which presents with clinical features including intellectual disabilities, obesity, and retinal degeneration, and, in mouse models, the added feature of hydrocephalus.
Minati Singh +3 more
doaj +1 more source
Frontiers in Endocrinology, 2011 Brain aromatase is expressed only in the nerve cells of specific brain regions with a transient peak at the neonatal period when sexual behaviors become organized. Aromatase knockout (ArKO) mouse, generated to give light on the physiological functions of
Nobuhiro eHarada +2 more
doaj +1 more source
The mouse set conjecture for sets of reals [PDF]
arXiv, 2021 Recall that the Mouse Set Conjecture says that under AD++V=L(P(R)), a real is ordinal definable if and only if it belongs to an iterable mouse. The Mouse Set Conjecture for sets of reals says that under the same theory, a set of reals is ordinal definable from a real if and only if it belongs to a mouse over the reals.
arxiv
Production of knockout mouse lines with Cas9
Methods, 2021 Knockout mice are used extensively to explore the phenotypic effects of mammalian gene dysfunction. With the application of RNA-guided Cas9 nuclease technology for the production of knockout mouse lines, the time, as well as the resources needed, to progress from identification of a gene of interest to production of a knockout line is significantly ...
Marina Gertsenstein, Lauryl M. J. Nutter
openaire +3 more sources
GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism. [PDF]
PLoS ONE, 2010 Nearly 1% of children in the United States exhibit autism spectrum disorders, but causes and treatments remain to be identified. Mice with deletion of the fragile X mental retardation 1 (Fmr1) gene are used to model autism because loss of Fmr1 gene ...
Marjelo A Mines +4 more
doaj +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Molecular Therapy: Methods & Clinical Development, 2021 Inducible conditional knockout mice are important tools for studying gene function and disease therapy, but their generation is costly and time-consuming.
Dan Xiao +10 more
doaj
Impact of taurine depletion on glucose control and insulin secretion in mice
Journal of Pharmacological Sciences, 2015 Taurine, an endogenous sulfur-containing amino acid, is found in millimolar concentrations in mammalian tissue, and its tissue content is altered by diet, disease and aging.
Takashi Ito +3 more
doaj +1 more source
How to Design a Stable Serial Knockout Competition [PDF]
arXiv, 2022 We investigate a new tournament format that consists of a series of individual knockout tournaments; we call this new format a Serial Knockout Competition (SKC). This format has recently been adopted by the Professional Darts Corporation. Depending on the seedings of the players used for each of the knockout tournaments, players can meet in the various
arxiv