Results 61 to 70 of about 406,670 (317)

COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022
Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley   +1 more source

Functional Expression Study of Igf2 Antisense Transcript in Mouse

International Journal of Genomics, 2014
Insulin-like growth factor antisense gene (Igf2as) expression was investigated in different mouse tissues during development, in differentiating C2C12 cells and in a ΔDMR1-U2 knockout mouse model.
Carolina Duart-Garcia, Martin H. Braunschweig   +1 more
doaj   +1 more source

Construction of GPR183 knockout mice and its function in acute liver injury

Di-san junyi daxue xuebao, 2021
Objective To construct a GPR183 knockout mouse model by genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system, and to analyze the role of GPR183 receptor in lymphocyte regulation
WU Xuewen, YIN Siqi, QIAN Ying, DU Bing, QIN Juliang, CHEN Jinlian   +5 more
doaj   +1 more source

Correlation between Unconscious Mouse Actions and Human Cognitive Workload [PDF]

arXiv, 2022
Unconscious behaviors are one of the indicators of the human perception process from a psychological perspective. As a result of perception responses, hand gestures show behavioral responses from given stimuli. Mouse usages in Human-Computer Interaction (HCI) show hand gestures that individuals perceive information processing.
arxiv  

Threshold Energies for Single Carbon Knockout from Polycyclic Aromatic Hydrocarbons [PDF]

J Phys Chem Lett 2015 6 4504, 2015
We have measured absolute cross sections for ultrafast (fs) single-carbon knockout from Polycyclic Aromatic Hydrocarbon (PAH) cations as functions of He-PAH center-of-mass collision energy in the range 10-200 eV. Classical Molecular Dynamics (MD) simulations cover this range and extend up to 10$^5$ eV. The shapes of the knockout cross sections are well
arxiv   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls, Abel Torres‐Espin, Marc Tormo, Laura Martínez‐Escardó, Núria Bonet, Ferran Casals, Xavier Navarro, Víctor J. Yuste, Esther Udina, Jordi Bruna   +9 more
wiley   +1 more source

Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening

Disease Models & Mechanisms, 2013
Identifying genes that are important for embryo development is a crucial first step towards understanding their many functions in driving the ordered growth, differentiation and organogenesis of embryos.
David Adams, Richard Baldock, Shoumo Bhattacharya, Andrew J. Copp, Mary Dickinson, Nicholas D. E. Greene, Mark Henkelman, Monica Justice, Timothy Mohun, Stephen A. Murray, Erwin Pauws, Michael Raess, Janet Rossant, Tom Weaver, David West   +14 more
doaj   +1 more source

A Deep Learning Framework for Classification of in vitro Multi-Electrode Array Recordings [PDF]

arXiv, 2019
Multi-Electrode Arrays (MEAs) have been widely used to record neuronal activities, which could be used in the diagnosis of gene defects and drug effects. In this paper, we address the problem of classifying in vitro MEA recordings of mouse and human neuronal cultures from different genotypes, where there is no easy way to directly utilize raw sequences
arxiv  

Altered cortical Cytoarchitecture in the Fmr1 knockout mouse [PDF]

Molecular Brain, 2019
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by silencing of the FMR1 gene and subsequent loss of its protein product, fragile X retardation protein (FMRP). One of the most robust neuropathological findings in post-mortem human FXS and Fmr1 KO mice is the abnormal increase in dendritic spine densities, with the majority of spines ...
Ping Su, Fang Liu, Fang Liu, Frankie H. F. Lee, Terence K. Y. Lai, Terence K. Y. Lai   +5 more
openaire   +4 more sources