Results 81 to 90 of about 415,720 (292)
Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain [PDF]
, 1996 Joe Z. Tsien +8 more
openalex +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
CRISPR/Cas9 PlatformCB is a global leading biotechnology company specializing in gene editing and has extensive experience and expertise in embryology (e.g. cryopreservation, microinjection), genetic testing and breeding. Using the latest CRISPR/Cas9 gene editing technology, our scientists have successfully achieved highly efficient CRISPR/Cas9 gene ...
openaire +1 more source
Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest
Biology Open, 2014 PDCD2 (programmed cell death domain 2) is a highly conserved, zinc finger MYND domain-containing protein essential for normal development in the fly, zebrafish and mouse. The molecular functions and cellular activities of PDCD2 remain unclear.
Celine J. Granier +6 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb β s -globin yeast artificial chromosome: A mouse model of sickle cell anemia [PDF]
, 1998 Judy C. Chang +10 more
openalex +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Generation of C57BL/6 knockout mice using C3H × BALB/c blastocysts
BioTechniques, 2008 The International Mouse Knockout Consortium aims to generate a knockout mouse for every single gene on a C57BL/6 background. Our ability to generate such mice is hampered by the poor economics of producing blastocysts to achieve germline transmission of ...
Gabriela Pacholczyk +4 more
doaj +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
In vivo blood flow abnormalities in the transgenic knockout sickle cell mouse [PDF]
, 1999 Stephen H. Embury +4 more
openalex +1 more source